Pyridines and derivatives
Apexbio Technology LLC Estropipate 7280-37-7 50mg
Estropipate (7280-37-7) is a small-molecule agonist targeting estrogen receptors (ER) It is designed to activate ERs thereby modulating gene transcription and regulation of cell proliferation via estrogen receptor signaling pathways Estropipate exerts its biological activity primarily through metabolic conversion to active estrogens which bind to intracellular ERs and initiate receptor-mediated signaling Based on these pharmacological properties Estropipate holds research potential in the investigation of menopause-related physiological effects and estrogen-dependent bone metabolism and is frequently used in experimental models of osteoporosis and menopause-associated symptom management
Apexbio Technology LLC Denifanstat 1399177-37-7 1mg
Denifanstat (CAS 1399177-37-7) also known as TVB-2640 is an orally bioavailable and selective inhibitor of fatty acid synthase (FASN) a critical enzyme involved in lipid biosynthesis in tumor cells By blocking FASN activity Denifanstat impedes endogenous fatty acid production thereby suppressing lipid metabolism essential for cancer cell proliferation The compound demonstrates potent inhibitory activity with an IC50 of 0 052 M for FASN and an EC50 of 0 072 M in cellular assays indicating effective target engagement at low concentrations Currently in clinical investigations Denifanstat is being studied as a novel agent for targeting lipid metabolism in cancer research
Apexbio Technology LLC Denifanstat 1399177-37-7 10mg
Denifanstat (CAS 1399177-37-7) also known as TVB-2640 is an orally bioavailable and selective inhibitor of fatty acid synthase (FASN) a critical enzyme involved in lipid biosynthesis in tumor cells By blocking FASN activity Denifanstat impedes endogenous fatty acid production thereby suppressing lipid metabolism essential for cancer cell proliferation The compound demonstrates potent inhibitory activity with an IC50 of 0 052 M for FASN and an EC50 of 0 072 M in cellular assays indicating effective target engagement at low concentrations Currently in clinical investigations Denifanstat is being studied as a novel agent for targeting lipid metabolism in cancer research
Apexbio Technology LLC Denifanstat 1399177-37-7 5mg
Denifanstat (CAS 1399177-37-7) also known as TVB-2640 is an orally bioavailable and selective inhibitor of fatty acid synthase (FASN) a critical enzyme involved in lipid biosynthesis in tumor cells By blocking FASN activity Denifanstat impedes endogenous fatty acid production thereby suppressing lipid metabolism essential for cancer cell proliferation The compound demonstrates potent inhibitory activity with an IC50 of 0 052 M for FASN and an EC50 of 0 072 M in cellular assays indicating effective target engagement at low concentrations Currently in clinical investigations Denifanstat is being studied as a novel agent for targeting lipid metabolism in cancer research
Medchemexpress LLC Inobrodib | 2222941-37-7 | 534.60 | 50 MG
Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. It binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, showing 170/130-fold selectivity compared with BRD4 (Kd of 222 nM). It inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression. Inobrodib also suppresses the growth of mouse xenograft models with an associated reduction in AR signaling.
- Potent and selective inhibitor of p300/CBP bromodomain
- Binds to p300 and CBP with high affinity
- Exhibits significant selectivity over BRD4
- Inhibits cell proliferation in prostate cancer cell lines
- Decreases androgen receptor (AR)- and C-MYC-regulated gene expression
- Suppresses tumor growth in mouse xenograft models
Medchemexpress LLC Glucoerucin potassium | 15592-37-7 | 1 MG
Glucoerucin potassium is an aryl hydrocarbon receptor antagonist and is the 4-methylthio-butyl glucosinolate found in the seeds of Eruca sativa Mill. This compound is intended for research use only and not for patient administration.
- Aryl hydrocarbon receptor antagonist
- Derived from Eruca sativa Mill seeds
- Purity of 99.73%
- Molecular weight of 459.60
- Appears as a white to off-white solid
- Suitable for research applications
Medchemexpress LLC 7-hydroxymethotrexate | 5939-37-7 | MFCD00674903 | 98.1% | C20H22N8O6 | 10MG
7-Hydroxymethotrexate is the major oxidative metabolite of methotrexate provided as a research-grade analytical standard for metabolic and pharmacokinetic studies. Key identifiers include CAS 5939-37-7, molecular formula C20H22N8O6, molecular weight 470.44 g·mol⁻1, and reported purity 98.14%.
- High purity for analytical and metabolic studies.
- Available in small milligram pack sizes for research use.
- Characterized by molecular formula C20H22N8O6 and molecular weight 470.44 g·mol⁻1.
- Supplied with supporting product information and datasheet for traceability.
- Suitable as a reference standard in pharmacokinetic and biochemical assays.
Medchemexpress LLC Cloperastine fendizoate | 85187-37-7 | 99.5% | 1 G
Cloperastine fendizoate | 85187-37-7 | 99.5% | 1 G
Medchemexpress LLC Aminoacylase (Acylase I) | 9012-37-7 | 50 MG
Aminoacylase (Acylase I) is a specific N-acetylglutamine metabolic-degrading enzyme. It serves as a key enzyme in the intracellular amino acid recycling pathway and offers detoxifying properties.
- Solid appearance, off-white to light brown
- Derived from porcine kidney
- Activity of 1825 unit/mg protein
- One unit hydrolyzes 1.0 micromole of N-Acetyl-L Methionine per hour at pH 7.0 at 25°C
Medchemexpress LLC Denifanstat | 1399177-37-7 | 99.6% | 439.55 | 1 ML
Denifanstat is an orally active and potent Fatty Acid Synthase (FASN) inhibitor. It demonstrates an IC50 of 0.052 μM and an EC50 of 0.072 μM. This compound holds potential for research in fatty liver disease and cancer, as its FASN inhibition mechanism also prevents palmitoylation of SARS-CoV2 spike protein.
- Orally active and potent Fatty Acid Synthase (FASN) inhibitor.
- IC50 of 0.052 μM and EC50 of 0.072 μM.
- Potential for fatty liver disease and cancer research.
- FASN inhibition prevents palmitoylation of SARS-CoV2 spike protein.
Medchemexpress LLC Direct Black 38 | 1937-37-7 | 1 G
Direct Black 38 (Chlorazol Black E) is a benzidine-based azo dye primarily used for textile dyeing. It is biodegradable when reduced by microbial enzymes, breaking its azo bonds to release benzidine and 4-aminobiphenyl. It can be used in environmental toxicology, wastewater treatment, and carcinogenicity studies.
- Benzidine-based azo dye and substrate of Enterococcus gallinarum.
- Primarily used for textile dyeing.
- Biodegradable by microbial enzymes.
- Suitable for environmental toxicology, wastewater treatment, and carcinogenicity studies.
- Appears as a solid, light brown to black powder.
- Soluble in DMSO (25 mg/mL) and H2O (5 mg/mL) with sonication.
Medchemexpress LLC Cryosim-3 | 1507344-37-7 | 99.9% | 1 MG
Cryosim-3 is a selective TRPM8 receptor agonist that has been shown to increase tear secretion and relieve ocular discomfort in animal models.
- Selective TRPM8 receptor agonist
- Increases tear secretion
- Relieves ocular discomfort in animal models
Medchemexpress LLC Cloperastine fendizoate | 85187-37-7 | 99.53% | 5 G
Cloperastine fendizoate is a potassium channel inhibitor that demonstrates concentration-dependent inhibition of hERG K+ currents. It is recognized for its antitussive (cough suppressing) and antiedemic properties, in addition to its ability to relax bronchial musculature. The compound also exhibits antihistaminic effects and a papaverine-like activity.
- Inhibits hERG K+ currents with an IC50 of 27 nM.
- Possesses antitussive and antiedemic activity.
- Relaxes bronchial musculature.
- Exhibits antihistaminic and papaverine-like activity.
- Has relatively low acute toxicity when administered orally (LD50 in rats and mice exceeds 2000 mg/kg).
Medchemexpress LLC Inobrodib | 2222941-37-7 | 99.9% | 534.60 | 100 MG
Inobrodib | 2222941-37-7 | 99.9% | 534.60 | 100 MG
Medchemexpress LLC Amidosulfuron | 120923-37-7 | MFCD01310639 | 98.4% | 50 MG
Amidosulfuron is a herbicide that targets acetohydroxyacid synthase (AHAS) and is highly effective against dicot broad-leaf weeds. It is for research use only.
- Targets acetohydroxyacid synthase (AHAS)
- Highly effective against dicot broad-leaf weeds
- Reduces photosynthetic rate in treated plants
- Reduces leaf chlorophyll, soluble sugar and pyruvate content
- Alters content of several free amino acids
- Appears as a white to off-white solid
- Soluble in DMSO