Pyridines and derivatives
3-Pyridinecarboxylic Anhydride 97.0+%, TCI America™
CAS: 16837-38-0 Molecular Formula: C12H8N2O3 Molecular Weight (g/mol): 228.207 InChI Key: VPODXHOUBDCEHN-UHFFFAOYSA-N Synonym: Nicotinic Anhydride PubChem CID: 85607 IUPAC Name: pyridine-3-carbonyl pyridine-3-carboxylate SMILES: C1=CC(=CN=C1)C(=O)OC(=O)C2=CN=CC=C2
Borane - 2-Methylpyridine Complex 85.0+%, TCI America™
CAS: 3999-38-0 Molecular Formula: C6H10BN Molecular Weight (g/mol): 106.96 MDL Number: MFCD07784361 InChI Key: ZMASBEFBIXMNCP-UHFFFAOYSA-N Synonym: Borane - 2-Picoline Complex, 2-Picoline Borane, 2-Methylpyridine Borane IUPAC Name: 2-methylpyridine borane SMILES: B.CC1=CC=CC=N1
Apexbio Technology LLC SAR407899 923359-38-0 2mg
SAR407899 (CAS 923359-38-0) is an ATP-competitive inhibitor that selectively targets the ROCK-2 isoform of Rho-associated protein kinases It demonstrates an IC50 of 135 nM for ROCK-2 and binds with Ki values of 36 nM and 41 nM for human and rat ROCK-2 respectively Through selective modulation of the ROCK signaling pathway SAR407899 has been shown to sustain inhibition of migration complex formation in cellular models This compound is thus suited for investigating cell migration cytoskeletal reorganization and the functional role of ROCK signaling in biomedical research
Apexbio Technology LLC SAR407899 923359-38-0 50mg
SAR407899 (CAS 923359-38-0) is an ATP-competitive inhibitor that selectively targets the ROCK-2 isoform of Rho-associated protein kinases It demonstrates an IC50 of 135 nM for ROCK-2 and binds with Ki values of 36 nM and 41 nM for human and rat ROCK-2 respectively Through selective modulation of the ROCK signaling pathway SAR407899 has been shown to sustain inhibition of migration complex formation in cellular models This compound is thus suited for investigating cell migration cytoskeletal reorganization and the functional role of ROCK signaling in biomedical research
Apexbio Technology LLC NS3694 426834-38-0 10mg
NS3694 (CAS 426834-38-0) is a diarylurea small molecule that functions as an inhibitor of apoptosome formation and caspase activation In HeLa cell cytosolic extracts NS3694 demonstrates an IC50 of approximately 50 M for the inhibition of cytochrome c-induced caspase activity It blocks the association of caspase 9 and Apaf-1 thereby preventing assembly of the functional 700-kDa apoptosome complex without directly inhibiting recombinant caspase 9 or caspase 3 NS3694 does not affect TNF-induced or FasL-induced caspase activation in other contexts This compound serves as a research tool for investigating intrinsic apoptotic signaling and apoptosome-mediated caspase activation in vitro
Apexbio Technology LLC NS3694 426834-38-0 50mg
NS3694 (CAS 426834-38-0) is a diarylurea small molecule that functions as an inhibitor of apoptosome formation and caspase activation In HeLa cell cytosolic extracts NS3694 demonstrates an IC50 of approximately 50 M for the inhibition of cytochrome c-induced caspase activity It blocks the association of caspase 9 and Apaf-1 thereby preventing assembly of the functional 700-kDa apoptosome complex without directly inhibiting recombinant caspase 9 or caspase 3 NS3694 does not affect TNF-induced or FasL-induced caspase activation in other contexts This compound serves as a research tool for investigating intrinsic apoptotic signaling and apoptosome-mediated caspase activation in vitro
Apexbio Technology LLC NS3694 426834-38-0 25mg
NS3694 (CAS 426834-38-0) is a diarylurea small molecule that functions as an inhibitor of apoptosome formation and caspase activation In HeLa cell cytosolic extracts NS3694 demonstrates an IC50 of approximately 50 M for the inhibition of cytochrome c-induced caspase activity It blocks the association of caspase 9 and Apaf-1 thereby preventing assembly of the functional 700-kDa apoptosome complex without directly inhibiting recombinant caspase 9 or caspase 3 NS3694 does not affect TNF-induced or FasL-induced caspase activation in other contexts This compound serves as a research tool for investigating intrinsic apoptotic signaling and apoptosome-mediated caspase activation in vitro
Apexbio Technology LLC NS3694 426834-38-0 5mg
NS3694 (CAS 426834-38-0) is a diarylurea small molecule that functions as an inhibitor of apoptosome formation and caspase activation In HeLa cell cytosolic extracts NS3694 demonstrates an IC50 of approximately 50 M for the inhibition of cytochrome c-induced caspase activity It blocks the association of caspase 9 and Apaf-1 thereby preventing assembly of the functional 700-kDa apoptosome complex without directly inhibiting recombinant caspase 9 or caspase 3 NS3694 does not affect TNF-induced or FasL-induced caspase activation in other contexts This compound serves as a research tool for investigating intrinsic apoptotic signaling and apoptosome-mediated caspase activation in vitro
Apexbio Technology LLC 2-Deoxyinosine 890-38-0 100mg
2-Deoxyinosine (CAS 890-38-0) is a purine nucleoside composed of the base hypoxanthine linked to a deoxyribose sugar Structurally analogous to natural DNA nucleosides 2-deoxyinosine can be incorporated into DNA during replication or repair where it may induce mispairing and promote mutagenesis This property makes it a valuable tool in studies of DNA damage mutational mechanisms and nucleotide metabolism Additionally 2-deoxyinosine is used in enzymatic assays to investigate nucleoside metabolism and the activity of purine nucleoside phosphorylase or related enzymes in biochemical and cellular contexts
Apexbio Technology LLC 2-Deoxyinosine 890-38-0 500mg
2-Deoxyinosine (CAS 890-38-0) is a purine nucleoside composed of the base hypoxanthine linked to a deoxyribose sugar Structurally analogous to natural DNA nucleosides 2-deoxyinosine can be incorporated into DNA during replication or repair where it may induce mispairing and promote mutagenesis This property makes it a valuable tool in studies of DNA damage mutational mechanisms and nucleotide metabolism Additionally 2-deoxyinosine is used in enzymatic assays to investigate nucleoside metabolism and the activity of purine nucleoside phosphorylase or related enzymes in biochemical and cellular contexts
Medchemexpress LLC Daurab2 | 3115765-38-0 | 1049.02 | 25 MG
dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B, reducing N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. It is suitable for the study of neuroblastoma.
- Potently degrades Aurora-A and Aurora-B with DC50s of 59 nM and 39 nM, respectively.
- Reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells.
- Can be used for neuroblastoma studies.
- A dual-degrading PROTAC.
Medchemexpress LLC Dithranol | 1143-38-0 | ≥98.0% | 1 ML
Dithranol, also known as Anthralin, is an anthraquinone derivative with potent anti-psoriatic effects. It functions by inhibiting DNA replication and repair mechanisms within cells. This compound is intended for research use only.
- Inhibits DNA replication and repair
- Potent anti-psoriatic effects
- Inhibits replication in T98G cells with a GI50 of 1.1 μM
- Increases mRNA production of interleukin-10 receptors in HaCaT cells
Medchemexpress LLC dAurAB2 | 3115765-38-0 | 1049.02 | 5 MG
dAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC50s of 59 nM and 39 nM, respectively. It reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells and can be used for the study of neuroblastoma.
- Potently degrades Aurora-A and Aurora-B
- Reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells
- Can be used for the study of neuroblastoma
- Product has not been fully validated for medical applications. For research use only.
Medchemexpress LLC Fructo-oligosaccharide DP14 | 137405-38-0 | 1 MG
Fructo-oligosaccharide DP14 is an oligosaccharide that can be isolated from Atractylodes lancea. It is a natural product intended for research use only.
- Purity: 98.58%
- Molecular weight: 2287.98
- Formula: C84H142O71
- CAS no.: 137405-38-0
- Appearance: Solid
- Color: White to off-white
- Structure classification: Saccharides, Polysaccharides
- Initial source: Plants (Leguminosae, Erythrina sigmoidea Hua; Compositae)
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, protected from light. In solvent: -80°C for 6 months; -20°C for 1 month (protected from light)
Medchemexpress LLC GSK180736A | 817194-38-0 | 98.8% | 365.36 | 50 MG
GSK180736A is a potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. It is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM. Structurally similar to paroxetine, it shows more potency and selectivity for GRK2 than other GRKs. ROCK1 is a potential therapeutic target in cardiovascular diseases like hypertension, and GSK180736A is a weak inhibitor of PKA with an IC50 of 30 μM.
- Potent rho-associated coiled-coil kinase 1 (ROCK1) inhibitor (IC50 = 100 nM)
- Selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor (IC50 = 0.77 μM)
- Structurally similar to paroxetine
- More than 100-fold selectivity over other GRKs
- Potential therapeutic agent for cardiovascular diseases such as hypertension
- Weak PKA inhibitor (IC50 = 30 μM)