Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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2,116 – 2,130 of 4,547 results

2,116

Apexbio Technology LLC APEXBIO TECHNOLOGY LLC

5000567902 TACALCITOL-MONOHYDRATE-1MG

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2,117

eMolecules EMOLECULES INC

5000495997 STATTIC 250MG

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2,118

eMolecules EMOLECULES INC

5000495994 RITONAVIR 250MG

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2,119

Medchemexpress LLC Ethyl Caffeate | 102-37-4 | 25 MG

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. It suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin. It is for research use only and not sold to patients.

Suppresses NF-κB activation
Inhibits inflammatory mediators, including iNOS, COX-2, and PGE2
Markedly suppresses LPS-induced nitric oxide (NO) production
Targets iNOS, NF-κB, and COX-2
Isolated from Bidens pilosa

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2,120

Medchemexpress LLC 5'-Guanylic acid | 85-32-5 | 25MG

5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. It also regulates the expression of genes related to fatty acid metabolism.

Weak agonist for ionotropic glutamate receptors (iGluR).
Reduces the activity of the glutamatergic system.
Exhibits neuroprotective effect.
Can also cause neuronal cell death at high concentrations.

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2,121

Medchemexpress LLC (E)-2-Hydroxycinnamaldehyde | 60125-23-7 | 250 MG

(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be isolated from the stem bark of cinnamon. It functions by inhibiting cell proliferation and inducing apoptosis through the suppression of STAT3 signal transduction and reactive oxygen species production. This compound exhibits antitumor activity.

Inhibits cell proliferation
Induces apoptosis by suppressing STAT3 signal transduction
Induces apoptosis by suppressing reactive oxygen species production
Exhibits antitumor activity

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2,122

Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 311.29 | 1 ML

N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. It hinders reverse transcriptase-mediated cDNA synthesis and affects sequencing efficiency in high-throughput RNA sequencing. It can be selectively demethylated by AlkB mutant enzymes into N2-methylguanosine, which reduces its hindrance to reverse transcription.

Methylated nucleoside present in RNA.
Structural modification component of tRNA.
Hinders reverse transcriptase-mediated cDNA synthesis.
Affects sequencing efficiency in high-throughput RNA sequencing.
Can be selectively demethylated by AlkB mutant enzymes.
Reduces hindrance to reverse transcription after conversion to N2-methylguanosine.

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2,123

Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 1 MG

N2,N2-Dimethylguanosine is a methylated nucleoside found in RNA and tRNA. It interferes with reverse transcriptase-mediated cDNA synthesis and impacts high-throughput RNA sequencing efficiency. The compound can be selectively demethylated by AlkB mutant enzymes into N2-methylguanosine, which helps to reduce reverse transcription hindrance.

Methylated nucleoside present in RNA and tRNA.
Hinders reverse transcriptase-mediated cDNA synthesis.
Affects sequencing efficiency in high-throughput RNA sequencing.
Can be converted to N2-methylguanosine by AlkB mutant enzymes to reduce reverse transcription hindrance.

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2,124

Medchemexpress LLC Cholest-4-en-3-one | 601-57-0 | 99.8% | 384.64 | 250 MG

Cholestenone (4-cholesten-3-one) is an orally available antimicrobial agent metabolized primarily in the liver as an intermediate oxidation product of cholesterol. It inhibits human dermal fibroblast migration and combats Helicobacter pylori infection in vitro and in mouse models by inhibiting cholesterol-α-D-glucopyranoside (CGL). Cholestenone also helps alleviate metabolic disorders caused by obesity in db/db mice.

Orally available antimicrobial agent
Metabolized as an intermediate oxidation product of cholesterol
Inhibits human dermal fibroblast migration
Combats Helicobacter pylori infection in vitro and in mouse models
Alleviates metabolic disorders caused by obesity in db/db mice
Reduces plasma cholesterol levels in dogs and chickens

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2,125

Medchemexpress LLC Patiromer | 1208912-84-8 | 95.0% | 250 MG

Patiromer is an orally active, selective, and non-absorbable intestinal potassium (K+) polymer binder. It reversibly binds potassium ions in exchange for calcium (Ca2+), rapidly and continuously reducing serum potassium levels. It helps maintain a normal blood potassium state, reduces serum aldosterone levels, and increases fecal potassium excretion. Patiromer is mainly used in the study of hyperkalemia associated with conditions such as chronic kidney disease, diabetes, and heart failure, and is particularly suitable for improving renin-angiotensin-aldosterone system inhibitor (RAASi) therapy.

Orally active
Selective and non-absorbable intestinal potassium (K+) polymer binder
Reversibly binds potassium ions in exchange for calcium (Ca2+)
Increases fecal potassium excretion
Sodium-free
High-capacity potassium binding properties
Poorly soluble in water (for in vivo preparation)

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2,126

Medchemexpress LLC Butanoic acid, 2-hydroxy-, (2R)- | 20016-85-7 | 99.9% | 104.10 | 250 MG

(R)-2-Hydroxybutanoic acid is an isomer of 2-Hydroxybutyric acid and can serve as an experimental control. This compound is a byproduct of insulin resistance, which can lead to impaired insulin signaling and mitochondrial overload. It enhances the viability of BRL3A, AML12, and primary mouse hepatocytes, and reduces AP-induced cytotoxicity.

Isomer of 2-hydroxybutyric acid
Can be used as an experimental control
Enhances cell viability and reduces cytotoxicity in certain cell lines
Appearance: solid (<50°C), liquid (>54°C)
Color: colorless to off-white

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2,127

Medchemexpress LLC 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- | 871258-12-7 | 99.5% | 616.06 | 250 MG

DLinDMA is an ionizable cationic lipid that serves as a key lipid component and benchmark for stable nucleic acid lipid particles (SNALPs). It is utilized for siRNA delivery. The structure of DLinDMA consists of three primary regions: the hydrocarbon chains, the linker, and the headgroup. It has demonstrated virtually indistinguishable blood pharmacokinetic profiles in mice.

Ionizable cationic lipid
Key lipid component of stable nucleic acid lipid particles (SNALPs)
Used for siRNA delivery

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2,128

Medchemexpress LLC Mevalonic acid lithium salt | 2618458-93-6 | 98.0% | 154.09 | 250 MG

Mevalonic acid lithium salt, also known as MVA lithium salt, is a precursor in the mevalonate pathway, which plays a vital role in cell growth and proliferation. It has been shown to inhibit simvastatin-induced decreases in C2C12 cell viability in vitro and is relevant for research into myopathy and heart failure.

Essential for cell growth and proliferation studies.
Inhibits simvastatin-induced decrease in C2C12 cell viability.
Useful for myopathy and heart failure research.
Shortens activated partial thromboplastin time (APTT) and prothrombin time (PT) in mice.
Increases thrombus weight in mice.
Increases infarct volume after transient middle cerebral artery occlusion in mice.
Determines cell proliferation in HCT116 and LoVo cells.
Assesses changes in YAP expression in HOS and MG63 cells.

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2,129

Medchemexpress LLC 1,2-Diaminoanthraquinone | 1758-68-5 | 91.1% | 238.25 | 250 MG

1,2-Diaminoanthraquinone is a sensitive, specific, and nontoxic nitric oxide (NO) fluorescent probe. It can be used to detect NO productions in live cells and animals. Its maximum absorption is at about 540 nm and it has a detection limit of 5 μM for NO.

Sensitive, specific, and nontoxic nitric oxide (NO) fluorescent probe
Can be used to detect NO productions in live cells and animals
Maximum absorption at about 540 nm
Detection limit of 5 μM for NO
Spectrally resolved using fluorescence spectroscopy and confocal microscopy
Reacts with NO in the presence of oxygen in the intracellular environment to yield DAA-TZ

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2,130

Medchemexpress LLC Tricosanoic acid | 2433-96-7 | 99.9% | 354.62 | 250 MG

Tricosanoic acid is an endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1. It can activate hair growth and improve cognitive function by regulating neuronal membrane fluidity, inhibiting neuroinflammatory response, and participating in myelination and neuronal energy metabolism. Low expression levels are observed in Alzheimer's disease models, with higher serum concentrations correlating to improved cognitive performance, making it a potential biomarker for cognitive decline.

Endogenous agonist of long-chain saturated fatty acids and free fatty acid receptor FFAR1
Activates hair growth
Improves cognitive function
Inhibits neuroinflammatory response
Participates in myelination and neuronal energy metabolism
Functions as a biomarker for cognitive decline

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Pyrimidines And Derivatives

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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethyl Caffeate | 102-37-4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5'-Guanylic acid | 85-32-5 | 25MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (E)-2-Hydroxycinnamaldehyde | 60125-23-7 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 311.29 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cholest-4-en-3-one | 601-57-0 | 99.8% | 384.64 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Patiromer | 1208912-84-8 | 95.0% | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Butanoic acid, 2-hydroxy-, (2R)- | 20016-85-7 | 99.9% | 104.10 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-Propanamine, N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- | 871258-12-7 | 99.5% | 616.06 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mevalonic acid lithium salt | 2618458-93-6 | 98.0% | 154.09 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1,2-Diaminoanthraquinone | 1758-68-5 | 91.1% | 238.25 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tricosanoic acid | 2433-96-7 | 99.9% | 354.62 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More