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Filtered Search Results
Medchemexpress LLC MMAE-SMCC | 2021179-11-1 | 95.7% | 1140.43 | C58H89N7O14S | 5 MG
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MMAE-SMCC is an antibody-drug conjugate (ADC) linker-payload conjugate that couples the cytotoxic agent monomethyl auristatin E (MMAE) to an SMCC linker for ADC research applications. It is supplied as a dry powder for research use only, with reported purity of approximately 95.65%, molecular formula C58H89N7O14S, and molecular weight 1140.43. Store at -20 °C, protect from light, and store under nitrogen. The compound is unstable in solution; prepare fresh solutions before use.
- Composed of monomethyl auristatin E linked via an SMCC linker.
- High purity suitable for research (95.7%).
- Supplied as a dry powder; store at -20 °C and protect from light.
- Unstable in solution; prepare fresh solutions prior to use.
- Intended for research use only.
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eMolecules 55750-62-4 | BMPS | ChemScene | MFCD00043141 | 266.209 | C11H10N2O6 | 95.000 | O=C(CCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 100g | 582637917
BMPS | ChemScene | 55750-62-4 | MFCD00043141 | 266.209 | C11H10N2O6 | 95.000 | O=C(CCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 100g | 582637917
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Medchemexpress LLC DEX-maleimide | 2754462-35-4 | 99.8% | C29H36FN3O7 | 50 MG
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DEX-maleimide is a coupling agent that can be used to synthesize conjugates containing single-domain antibodies (VHH) conjugated with antigens and anti-inflammatory agents. It is also applicable for research concerning autoimmune diseases.
- Used to synthesize conjugates containing single-domain antibodies (VHH) with antigens and anti-inflammatory agents.
- Applicable for research concerning autoimmune diseases.
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.75% | 341.36 | 100 MG
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies, exhibiting an IC50 value exceeding 100 μM. It effectively blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo, with an IC50 of 8 μM.
- Cell-permeable negative control for protein kinase C inhibition studies
- Exhibits an IC50 value exceeding 100 μM for protein kinase C inhibition
- Effectively blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo
- Has an IC50 of 8 μM for S6K activation blocking
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Medchemexpress LLC Maleimide | 541-59-3 | 97.07 | 1 G
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Maleimide is a chemical compound primarily used in cancer research for the production of antibody-drug conjugates (ADC). It also finds application in preparing fluorogenic probes for the specific detection of thiol analytes. This compound is known for its ability to bind rapidly and covalently to the sulfhydryl (-SH) group of cysteine residues, a characteristic that can be leveraged in drug delivery systems to enhance cell uptake efficiency.
- Used for production of antibody-drug conjugate (ADC) in cancer research.
- Leveraged for preparation of fluorogenic probes for specific detection of thiol analytes.
- Binds rapidly and covalently to sulfhydryl (-SH) group of cysteine residues.
- Can be used in drug delivery systems for improved cell uptake efficiency.
- Maleimide modified liposomes exhibit antitumor effects in mouse models.
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Medchemexpress LLC Mira-1 | 72835-26-8 | 99.8% | 183.16 g/mol | C8H9NO4 | 5 MG
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MIRA-1 (NSC 19630) is a maleimide-derived small-molecule research compound that restores wild-type conformation and transcriptional activity to mutant p53, triggering p53-dependent transcriptional transactivation and apoptosis in mutant p53 cancer cells. It has reported anticancer activity and an IC50 of approximately 10 μM against Saos-2 His273 cells. Provided as a high-purity reagent for in vitro and in vivo studies.
- Molecular formula: C8H9NO4.
- Molecular weight: 183.16 g/mol.
- Purity: 99.76%.
- Solubility: DMSO 100 mg/mL; in vivo vehicles soluble ≥2.5 mg/mL.
- Suggested storage: powder -20°C for long term; in solvent -80°C recommended.
- Reported activity: induces p53-dependent transcriptional transactivation and apoptosis.
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Enzo Life Sciences Bisindolylmaleimide III (5mg)
Potent and selective inhibitor of protein kinase C (PKC). Formula: C23H20N4O2. MW: 384.4. Purity: ≥98%. Solubility: Soluble in methanol or DMSO. Long Term Storage: -20°C.
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Selleck Chemical LLC Bisindolylmaleimide I
Bisindolylmaleimide I (GF109203X GO 6850) is a potent PKC inhibitor with IC50 of 20 nM 17 nM 16 nM and 20 nM for PKC PKC I PKC II and PKC in cell-free assays respectively showing more than 3000-fold selectivity for PKC as compared to EGFR PDGFR and insulin receptor
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Medchemexpress LLC 6-maleimidohexanoic acid N-hydroxysuccinimide ester | 55750-63-5 | MFCD00043043 | 100.0% | 308.29 g/mol | C14H16N2O6 | 500 MG
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a heterobifunctional cross-linking reagent containing maleimide and NHS ester reactive groups that enable selective conjugation between thiol and amine functionalities for preparation of hapten and enzyme immunoconjugates.
- Heterobifunctional reagent: maleimide and NHS ester groups.
- Reacts with thiols and primary amines for targeted conjugation.
- Molecular weight 308.29 g/mol; formula C14H16N2O6.
- High purity suitable for analytical and preparative applications.
- Available in multiple pack sizes, including 500 MG.
- Store sealed, away from moisture and light; store solid at -20°C.
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TARGETMOL CHEMICALS INC Bisindolylmaleimide X hydrochl
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor and a CDK2 antagonist with an IC50 of 200 nM. Purity 98.5%
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eMolecules 55750-62-4 | N-Succinimidyl 3-maleimidopropionate | Combi-Blocks | MFCD00043141 | 266.209 | C11H10N2O6 | 98.000 | O=C(CCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 10g | 249357176
N-Succinimidyl 3-maleimidopropionate | Combi-Blocks | 55750-62-4 | MFCD00043141 | 266.209 | C11H10N2O6 | 98.000 | O=C(CCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 10g | 249357176
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Medchemexpress LLC Biotin-maleimide | 116919-18-7 | MFCD28397114 | 99.7% | 451.54 g/mol | C20H29N5O5S | 5mg
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Biotin-maleimide is a biotinylated biochemical assay reagent which can be used as a thiol-specific probe Biotin-maleimide can also be used to prepare the biotin-conjugated polychelating agent[1]
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Medchemexpress LLC HY-100207 5mg Medchemexpress, CP21R7 CAS:125314-13-8 Purity:>98%
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Medchemexpress, HY-100207 5mg CP21R7 CAS:125314-13-8 CP21R7 is potent GSK-3β inhibitor, with an IC 50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα , with an IC 50 of 1900 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Mc-va-pabc-mmae | 1818864-51-5 | 1230.53 | C65H99N9O14 | 1 MG
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MC-VA-PABC-MMAE is a drug-linker conjugate for antibody-drug conjugate (ADC) research that couples a peptide-based linker to monomethyl auristatin E (MMAE), a potent tubulin polymerization inhibitor. It is intended for use in ADC assembly and preclinical characterization.
- Peptide-based ADC linker coupled to a tubulin inhibitor payload.
- Suitable for ADC assembly and preclinical characterization.
- Supplied in milligram quantities for research applications.
- Available in multiple sizes to support small-scale studies.
- Provides defined linker-payload chemistry for conjugation workflows.
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eMolecules 541-59-3 | Maleimide | Medchem Express | MFCD00005494 | 97.073 | C4H3NO2 | 98.000 | O=C1NC(=O)C=C1 | 1g | 824156095
Maleimide | Medchem Express | 541-59-3 | MFCD00005494 | 97.073 | C4H3NO2 | 98.000 | O=C1NC(=O)C=C1 | 1g | 824156095
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