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Filtered Search Results
Medchemexpress LLC (S,R,S)-AHPC-PEG2-N3 | 2010159-45-0 | 99.9% | 601.72 g/mol | C28H39N7O6S | 50 MG
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(S,R,S)-AHPC-PEG2-N3 is an E3 ligase ligand-linker conjugate containing an (S,R,S)-AHPC VHL ligand connected to a two-unit PEG linker and terminating in an azide. It is provided as a click-chemistry reagent for PROTAC assembly and linker installation.
- Contains a terminal azide compatible with CuAAC and SPAAC reactions.
- Designed for conjugation to alkyne-bearing molecules and strain-promoted partners.
- PEG2 linker provides flexibility and solubility for linker installation.
- Supplied as a research-grade reagent with characterized molecular weight and formula.
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Medchemexpress LLC HY-107425 1mg Medchemexpress, MZ 1 CAS:1797406-69-9 Purity:>98%
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Medchemexpress, HY-107425 1mg MZ 1 CAS:1797406-69-9 MZ 1 is a BRD4 protein degrader based on PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![Medchemexpress LLC 3-[2-(4-fluorophenyl)ethynyl]-N-[3-(1H-pyrazol-4-yl)propyl]-4-(4-pyridinyl)-benzamide | 1800487-55-1 | ≥98.0% | 424.5 g/mol | C26H21FN4O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000223246.png-250.jpg)
Medchemexpress LLC 3-[2-(4-fluorophenyl)ethynyl]-N-[3-(1H-pyrazol-4-yl)propyl]-4-(4-pyridinyl)-benzamide | 1800487-55-1 | ≥98.0% | 424.5 g/mol | C26H21FN4O | 5 MG
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OT-82 is a small-molecule nicotinamide phosphoribosyltransferase (NAMPT) inhibitor used in preclinical research to deplete cellular NAD+ and selectively induce cell death in hematopoietic-derived malignancies. The compound is supplied as a solid for laboratory use and has been characterized in cell-free and cellular assays demonstrating potent activity against NAMPT.
- Potent, selective NAMPT inhibitor suitable for research applications.
- Demonstrated cytotoxicity in hematologic cancer cell lines with low-nanomolar IC50s.
- Supplied as a solid, with reported purity of ≥98.0%.
- Molecular weight 424.5 g/mol; molecular formula C26H21FN4O.
- Intended for in vitro and preclinical studies; handle per SDS guidance.
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Medchemexpress LLC (S,R,S)-ahpc-c5-cooh (vh032-c5-cooh) | 2267282-19-7 | >98.0% | C29H42N4O5S | 10MG
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(S,R,S)-AHPC-C5-COOH is a von Hippel-Lindau (VHL) E3 ligase ligand-linker conjugate used as a synthetic building block in PROTAC and degrader synthesis. It contains an AHPC recognition motif with a five-carbon linker terminating in a carboxylic acid, enabling facile amide or ester coupling to target ligands. Supplied as a high-purity solid for medicinal chemistry research.
- High purity (>98%) suitable for synthesis and analytical work.
- Five-carbon linker terminating in a carboxylic acid for coupling chemistry.
- Designed for use as a VHL E3 ligase ligand in PROTAC assembly.
- Provided in small research quantities for medicinal chemistry workflows.
- Stable solid, typically white to off-white, for convenient handling.
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eMolecules (S, R, S)-AHPC-PEG4-acid | | | 500mg
Broadpharm | (S, R, S)-AHPC-PEG4-acid | 500mg | 518001003 | BP-24468 | 98.000 | | | 706.850 | C34H50N4O10S
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Medchemexpress LLC HY-10235 10mg Medchemexpress, Telaprevir CAS:402957-28-2 Purity:>98%
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Medchemexpress, HY-10235 10mg Telaprevir CAS:402957-28-2 Telaprevir is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Protac Bcl2 degrader-1 | 2378801-85-3 | 99.8% | 941.84 | C45H45BrN6O10S | 1MG
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PROTAC Bcl2 degrader-1 is a cereblon-based proteolysis targeting chimera (PROTAC) designed to induce ubiquitin-proteasome mediated degradation of antiapoptotic Bcl-2 family proteins. It is intended for cellular research into targeted protein degradation, apoptosis pathways, and mechanism-of-action studies; manufacturer data provide bioactivity, solubility, purity, and storage guidance to support experimental planning.
- Cereblon-based PROTAC that recruits CRBN E3 ligase.
- Induces selective degradation of Bcl-2 and Mcl-1 in cell assays.
- Reported bioactivity: Bcl-2 DC50 3 μM, Bcl-2 IC50 4.94 μM, Mcl-1 IC50 11.81 μM.
- Molecular formula C45H45BrN6O10S and molecular weight 941.84.
- High purity (99.8%) suitable for research use.
- Soluble in DMSO (≈25 mg/mL) and compatible with common in vivo formulations.
- Store at -20°C under inert atmosphere; in solvent store at -80°C for long term.
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Medchemexpress LLC Protac Mcl1 degrader-1 | 2163793-38-0 | 98.1% | 909.84 g/mol | C45H45BrN6O8S | 5MG
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PROTAC Mcl1 degrader-1 is a cereblon-based proteolysis targeting chimera (PROTAC) that induces ubiquitination and proteasomal degradation of the anti-apoptotic protein Mcl-1. It is provided as a small-molecule research compound for in vitro and in vivo studies; reported properties include molecular formula C45H45BrN6O8S, molecular weight 909.84 g/mol, CAS 2163793-38-0, and a reported IC50 of 0.78 μM for Mcl-1 activity. Recommended solvents and in vivo formulations are provided in the manufacturer datasheet.
- Induces cereblon-mediated degradation of Mcl-1.
- Potent Mcl-1 activity with reported IC50 of 0.78 μM.
- Molecular weight 909.84 g/mol and formula C45H45BrN6O8S.
- High solubility in DMSO; documented in vitro and in vivo formulations.
- Intended for biochemical and cell-based research applications.
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Selleck Chemical LLC ACT-1016-0707-E1941-25MG
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ACT-1016-0707 (LPA1 receptor antagonist 2) is an orally active and selective antagonist of LPA1 Receptor with IC50 of 3 1 nM for hLPAR1 in tango assay It has the potential to treat fibrotic diseases
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Medchemexpress LLC BAY-298 | 2471978-97-7 | 99.9% | 50 MG
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BAY-298 is an orally active and selective antagonist of the luteinizing hormone receptor (LH-R). It exhibits IC50 values of 96 nM for human LH (hLH), 23 nM for rat LH (rLH), and 78 nM for cynomolgus monkey LH (cLH). This compound has demonstrated the ability to reduce sex hormone levels and is intended for research use only.
- Orally active and selective LH-R antagonist
- Inhibits human, rat, and cynomolgus monkey LH-R
- Reduces sex hormone levels
- For research use only
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Medchemexpress LLC PROTAC CDK2/9 Degrader-1 | 2408641-24-5 | 99.9% | 50 MG
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PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). It suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. This compound is a PROTAC that functions by tethering a CDK inhibitor with a Cereblon ligand.
- Potent dual degrader for CDK2 and CDK9
- Suppresses prostate cancer PC-3 cell proliferation
- Functions by tethering a CDK inhibitor with a Cereblon ligand
- Induces cell cycle blockage at the G2/M phase
- Down-regulates Mcl-1 protein level
- Effectively degrades CDK2/9 in various cell lines
- Inhibits both CDK2 and CDK9
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Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.5% | 1107.26 | 50 MG
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Pasireotide acetate is a long-acting cyclohexapeptide somatostatin analogue that improves agonist activity at somatostatin receptors. It can suppress GH, IGF-I, and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. This compound also exhibits antisecretory, antiproliferative, and proapoptotic activity.
- Improves agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively).
- Suppresses GH, IGF-I, and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease.
- Exhibits antisecretory, antiproliferative, and proapoptotic activity.
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Medchemexpress LLC Taltirelin acetate (TA-0910 acetate) | 1549593-23-8 | 99.4% | 50 MG
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Taltirelin acetate (TA-0910 acetate) is an acetate form of Taltirelin (TA-0910), an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist. This compound can cross the blood-brain barrier and stimulates an increase in cytosolic Ca2+ concentration.
- Orally effective analogue of thyrotropin releasing hormone (TRH)
- TRH receptor (TRH-R) superagonist
- Can cross the blood-brain barrier
- Stimulates an increase in cytosolic Ca2+ concentration (Ca2+ release)
- Increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons
- Demonstrates neuroprotective effects in cellular and animal models of Parkinson's disease
- Alleviates fatigue-like behavior in mouse models of cancer-related fatigue
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Medchemexpress LLC Protac SGK3 degrader-1 | 2381320-35-8 | 99.9% | 1157.38 g/mol | C57H73FN10O11S2 | 1MG
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PROTAC SGK3 degrader-1 is a VHL-ligand-based PROTAC chemical probe developed to induce proteasomal degradation of SGK3 in cellular systems. It exhibits rapid, concentration-dependent activity and is supplied as a high-purity research reagent.
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Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 50 MG
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WSB1 Degrader 1 is a potent and orally active degrader of WSB1 (WD repeat and SOCS box-containing 1). It exhibits anticancer metastatic effects. In vitro studies show it induces WSB1 degradation in H1299-WSB1 cells in a time-dependent and dose-dependent manner. It also demonstrates potent antimigration efficacy in KHOS and H460 cell lines. In vivo, daily oral treatment effectively inhibited pulmonary metastasis in Balb/c (nu/nu) mice bearing highly metastatic 4T1 breast cancer cells.
- Induces WSB1 degradation in H1299-WSB1 cells
- Exhibits potent antimigration efficacy in KHOS and H460 cell lines
- Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells
- Elevates RhoGDI2 protein levels in KHOS cells under hypoxia
- Blocks the wound-healing capability of wild-type A2780 cells
- Effectively inhibits pulmonary metastasis of cancer cells in animal models
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