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Filtered Search Results
Medchemexpress LLC FABPs ligand 6 | 2988135-14-2 | 99.9% | C28H27FN2O3 | 100 MG
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FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM for FABP5 and 20 nM for FABP7. This compound rescues mitochondrial function by blocking voltage-dependent anion channel (VDAC)-1-dependent mitochondrial macropore formation, a mechanism involved in FABP5-mediated injury. It can be used for multiple sclerosis research, improving EAE severity and attenuating oxidative levels and inflammatory responses in mouse models.
- FABP5 and FABP7 inhibitor
- Rescues mitochondrial function
- Attenuates oxidative levels
- Inhibits inflammatory responses
- Protects oligodendrocytes
- Suitable for multiple sclerosis research
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Aobchem AOBCHEM
5001004618 PYRROLIDIN-1-YL M-TOLYL METHAN
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Medchemexpress LLC SU-4942 | 76086-99-2 | 99.6% | 300.15 | 25 MG
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SU-4942 is a tyrosine kinase signal modulator that inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells. It is for research use only.
- Inhibits VEGF- and ECGF-induced mitogenesis
- Suitable for laboratory research
- High purity (99.60%)
- Available in various solid and solution forms
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Medchemexpress LLC HY-17578 10mg Medchemexpress, Pneumocandin B0 CAS:135575-42-7 Purity:>98%
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Medchemexpress, HY-17578 10mg Pneumocandin B0 CAS:135575-42-7 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Hydroxyethyl starch | 9005-27-0 | MFCD00131356 | 100.7% | 170-230 kDa | (C6H10O5)m(C2H5O)n | 50 G
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Hydroxyethyl starch (MW 170-230 kDa) is a hydroxyethylated polysaccharide supplied for life-science research. It is provided as a white to off-white solid intended for use as a biochemical reagent or biological material when a defined high-molecular-weight starch derivative is required.
- Defined molecular weight range 170-230 kDa.
- White to off-white solid form with high assay purity.
- Low heavy metal content (<0.001%).
- Reported pH of approximately 5.3 on the COA.
- Intrinsic viscosity 17.4 (as reported on COA).
- Available in multiple pack sizes including 50 g for laboratory use.
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Medchemexpress LLC Boc-Aminooxy-PEG4-NH2 | 2062663-66-3 | 95.0% | C13H28N2O7 | 250 MG
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Boc-Aminooxy-PEG4-NH2 is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. These molecules are instrumental in drug discovery, facilitating the targeted degradation of specific proteins. By leveraging the intracellular ubiquitin-proteasome system, PROTACs offer a novel approach to modulating protein function.
- Peg-based protac linker
- Used in the synthesis of protacs
- Facilitates targeted protein degradation
- Utilizes the ubiquitin-proteasome system
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Medchemexpress LLC Amino-PEG10-Boc | 1818294-42-6 | 99.73% | C27H55NO12 | 250 MG
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Amino-PEG10-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These PROTACs harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Connects two different ligands via a linker
- One ligand binds to an E3 ubiquitin ligase, the other to the target protein
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Medchemexpress LLC Azido-PEG12-acid | 2152679-71-3 | 99.8% | C27H53N3O14 | 250 MG
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Azido-PEG12-acid is a PEG-based PROTAC linker that functions as a click chemistry reagent. It contains an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilize the intracellular ubiquitin-proteasome system to degrade target proteins.
- Used in the synthesis of PROTACs
- Click chemistry reagent with Azide group
- Participates in CuAAc reactions
- Participates in SPAAC reactions
- Utilizes the ubiquitin-proteasome system for protein degradation
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Medchemexpress LLC 1,2-dimyristoyl-rac-glycero-3-phosphocholine | 18656-38-7 | MFCD00066562 | ≥98.0% | 677.93 g/mol | C36H72NO8P | 250 MG
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1,2-Dimyristoyl-rac-glycero-3-phosphocholine (DMPC) is a zwitterionic phospholipid used as a simple model of eukaryotic plasma membranes. It readily forms bilayers and liposomes with a neutral surface charge, making it suitable for membrane biophysics, liposome formulation, and studies of lipid-protein interactions where a reproducible, neutral phospholipid matrix is required.
- Forms stable bilayers and liposomes for membrane models.
- Mimics the neutral charge of eukaryotic plasma membranes.
- Suitable for membrane biophysics and lipid-protein interaction studies.
- High purity for reproducible experimental results.
- Available in multiple sizes for small- and large-scale experiments.
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Medchemexpress LLC (Z)-FeCP-oxindole | 1137967-28-2 | 99.6% | 329.17 | 500 MG
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(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. It can significantly inhibit VEGFR1 and PDGFRα or β at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM.
- Target: VEGFR
- Pathway: Protein Tyrosine Kinase/RTK
- Storage: Powder: -20°C for 3 years, 4°C for 2 years; in solvent: -80°C for 6 months, -20°C for 1 month
- In vitro solubility: DMSO: 50 mg/mL (151.90 mM; need ultrasonic)
- IC50 & target: VEGFR2 (200 nM), VEGFR1
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Medchemexpress LLC Carbomer 941 (CBM 941) | 9007-20-9 | MFCD01675509 | 95.0% | ≈1,250,000 g/mol | C42H80O8 | 250 G
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Carbomer 941 is a crosslinked acrylic acid polymer used as a rheology modifier and thickening agent in formulation and pharmaceutical research. It forms high-viscosity, stable gels and provides a robust gel matrix for controlled release and topical applications. Supplied as a white to off-white powder with documented purity for laboratory use.
- Forms high-viscosity, stable gels.
- Acts as a rheology modifier and thickening agent.
- Provides controlled release and gel matrix stability.
- White to off-white solid powder, easy to weigh and disperse.
- Compatible with aqueous formulations and common excipients.
- Supplied with purity specification for quality control.
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eMolecules 1056881-04-9 | m-PEG8-bromide | Broadpharm | MFCD31380391 | 447.363 | C17H35BrO8 | 96.000 | COCCOCCOCCOCCOCCOCCOCCOCCBr | 1g | 354974905
m-PEG8-bromide | Broadpharm | 1056881-04-9 | MFCD31380391 | 447.363 | C17H35BrO8 | 96.000 | COCCOCCOCCOCCOCCOCCOCCOCCBr | 1g | 354974905
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Medchemexpress LLC Boc-NH-PEG8-CH2CH2COOH | 1334169-93-5 | MFCD13185254 | 99.94% | C24H47NO12 | 250 MG
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Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are innovative molecules that harness the cell's ubiquitin-proteasome system to selectively degrade target proteins, offering a novel approach in drug discovery.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Boc-Aminooxy-PEG2-C2-amine | 252378-69-1 | 98.0% | C11H24N2O5 | 250 MG
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Boc-Aminooxy-PEG2-C2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is for research use only.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- For research use only
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Medchemexpress LLC Boc-NH-PEG6-amine | 1091627-77-8 | 97.0% | C19H40N2O8 | 250 MG
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Boc-NH-PEG6-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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