Pyrrolidines
Medchemexpress LLC Dbco-nh-boc | 1539290-74-8 | C23H24N2O3 | 100 MG
DBCO-NH-Boc is an alkyl/ether-based PROTAC linker. It acts as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs are composed of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- Alkyl/ether-based PROTAC linker
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in the synthesis of PROTACs
Medchemexpress LLC DBCO-NH-Boc | 1539290-74-8 | C23H24N2O3 | 50 MG
DBCO-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid | 73401-74-8 | 166.18 | 1 ML
4-(Hydroxymethyl)phenylacetic acid can serve as the main body of insoluble polypeptide. It can react with DEPBT and 4-acetylaniline to form amide intermediates. This compound is a metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota. It significantly inhibits 6-MP oxidation and has no significant inhibition on xanthine oxidation.
- Can serve as the main body of insoluble polypeptide.
- Can react with DEPBT and 4-acetylaniline to form amide intermediates.
- A metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota.
- Significantly inhibits 6-MP oxidation.
- Has no significant inhibition on xanthine oxidation.
Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid | 73401-74-8 | 166.18 | 50 G
4-(Hydroxymethyl)phenylacetic acid is a metabolite resulting from the metabolism of flavonoids like quercetin by colonic microbiota. It acts as a main component of insoluble polypeptides and participates in reactions forming amide intermediates. This compound notably inhibits 6-MP oxidation, showing no significant effect on xanthine oxidation.
- Acts as main body of insoluble polypeptide
- Reacts to form amide intermediates
- Metabolite of flavonoids such as quercetin
- Significantly inhibits 6-MP oxidation
Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid | 73401-74-8 | 166.18 | 5 G
4-(Hydroxymethyl)phenylacetic acid (4HMPAA) serves as a main body of insoluble polypeptide. It can react with DEPBT and 4-acetylaniline to form amide intermediates. This compound is a metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota. It significantly inhibits 6-MP oxidation and has no significant inhibition on xanthine oxidation.
- Serves as main body of insoluble polypeptide.
- Reacts with DEPBT and 4-acetylaniline to form amide intermediates.
- Metabolite produced by metabolism of flavonoids such as quercetin.
- Significantly inhibits 6-MP oxidation.
Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid | 73401-74-8 | 166.18 | 25 G
4-(Hydroxymethyl)phenylacetic acid (4HMPAA) is a chemical compound that can serve as the main body of insoluble polypeptide. It is also a metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota and significantly inhibits 6-MP oxidation.
- Can serve as the main body of insoluble polypeptide
- Reacts with DEPBT and 4-acetylaniline to form amide intermediates
- Metabolite produced by the metabolism of flavonoids by colonic microbiota
- Significantly inhibits 6-MP oxidation
- Solid appearance, white to light yellow
- Melting/freezing point of 131-134°C
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid | 73401-74-8 | 166.18 | 10 G
4-(Hydroxymethyl)phenylacetic acid (4HMPAA) is a compound that functions as the primary structural component for insoluble polypeptides. It can participate in chemical reactions with DEPBT and 4-acetylaniline to generate amide intermediates. This compound is also recognized as a metabolite resulting from the breakdown of flavonoids, like quercetin, by colonic microbiota. Furthermore, 4HMPAA significantly inhibits 6-MP oxidation, demonstrating a selective inhibitory action as it does not considerably affect xanthine oxidation.
- Functions as the main body of insoluble polypeptides.
- Reacts with DEPBT and 4-acetylaniline to form amide intermediates.
- A metabolite derived from the metabolism of flavonoids such as quercetin by colonic microbiota.
- Exhibits significant inhibition of 6-MP oxidation.
- Shows no significant inhibition on xanthine oxidation.
Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid (4HMPAA) | 73401-74-8 | 166.18 | 100 G
4-(Hydroxymethyl)phenylacetic acid can serve as the main body of insoluble polypeptide. It can react with DEPBT and 4-acetylaniline to form amide intermediates. This compound is a metabolite produced by the metabolism of flavonoids such as quercetin by colonic microbiota. 4-(Hydroxymethyl)phenylacetic acid significantly inhibits 6-MP oxidation and has no significant inhibition on xanthine oxidation.
- Serves as main body of insoluble polypeptide
- Reacts with DEPBT and 4-acetylaniline to form amide intermediates
- Metabolite produced by colonic microbiota
- Significantly inhibits 6-MP oxidation
Medchemexpress LLC DBCO-NH-Boc | 1539290-74-8 | C₂₃H₂₄N₂O₃ | 25 MG
DBCO-NH-Boc is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent containing a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs are composed of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- Alkyl/ether-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in the synthesis of PROTACs
- Enables selective protein degradation via the ubiquitin-proteasome system
Medchemexpress LLC Alp/carbonic anhydrase-in-1 | 2091887-74-8 | 99.9% | 224.30 | C15H16N2 | 10 MG
ALP/Carbonic anhydrase-IN-1 is a research reagent: a small molecule dual inhibitor of carbonic anhydrase isoforms and alkaline phosphatase intended for in vitro biochemical and cell-based studies. It is provided as a high-purity solid suitable for screening and assay development.
- Dual inhibitor of carbonic anhydrase and alkaline phosphatase.
- High purity (99.9%) for reproducible experimental results.
- Molecular weight 224.30 and formula C15H16N2.
- Supplied as a 10 MG research pack for laboratory use.
- Documented inhibitory activity against multiple CA isoforms and ALP, useful for mechanism and screening studies.