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Filtered Search Results
Apexbio Technology LLC LY2608204 1234703-40-2 200mg
LY2608204 (CAS 1234703-40-2) is a small molecule activator of glucokinase (GK) enhancing its activity as indicated by an EC50 of 42 nM under low glucose conditions In the INS1-E rat insulinoma cell line LY2608204 stimulates glucose metabolism with an EC50 of 579 nM Preclinical studies have demonstrated that administration of LY2608204 leads to dose-dependent reductions in both fasting and postprandial blood glucose levels These properties make LY2608204 a valuable tool for investigating GK modulation and its effects on glucose homeostasis in metabolic disease research
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Apexbio Technology LLC Evacetrapib (LY2484595) 1186486-62-3 200mg
Evacetrapib (LY2484595 CAS 1186486-62-3) is a potent and selective inhibitor targeting cholesteryl ester transfer protein (CETP) a regulator of lipid metabolism Evacetrapib exhibits inhibitory activity with IC50 values of 5 5 nM in assays containing recombinant human CETP and 26 nM within human plasma CETP assays In vivo oral administration at 30 mg/kg in human CETP/ApoAI double-transgenic mice significantly reduces CETP activity and elevates HDL-cholesterol concentration (ED50 5 mg/kg) Evacetrapib does not elevate blood pressure nor induce aldosterone or cortisol synthesis in model systems highlighting its potential in cardiovascular research related to coronary artery disease
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![Medchemexpress LLC Ethanesulfonic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- | 1817735-43-5 | 99.5% | 257.30 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Ethanesulfonic acid, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- | 1817735-43-5 | 99.5% | 257.30 | 25 MG
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. They function by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Intended for research use only
- Appearance: oil, colorless to light yellow
- Target: PEGs
- Storage: -20°C under nitrogen
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eMolecules 288154-18-7 | tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Ambeed | MFCD04114477 | 243.307 | C11H21N3O3 | 95.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 5g | 552739298
tert-Butyl 4-amino-4-carbamoylpiperidine-1-carboxylate | Ambeed | 288154-18-7 | MFCD04114477 | 243.307 | C11H21N3O3 | 95.000 | CC(C)(C)OC(=O)N1CCC(N)(CC1)C(N)=O | 5g | 552739298
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Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 10 MG
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Sulfo-GMBS is a water-soluble, heterobifunctional cross-linking reagent containing a sulfo-NHS ester and a maleimide. It enables selective conjugation between primary amines and sulfhydryl groups in aqueous systems, making it suitable for protein and peptide bioconjugation, surface immobilization, and analytical assay development.
- Water-soluble heterobifunctional cross-linker for aqueous reactions.
- Reacts with primary amines via sulfo-NHS ester chemistry.
- Reacts with sulfhydryl groups via maleimide chemistry.
- Suitable for protein and peptide conjugation and surface immobilization.
- Provided in small solid quantities for laboratory-scale use.
- High purity for consistent conjugation performance.
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Medchemexpress LLC Indisulam | 165668-41-7 | MFCD00945325 | 99.8% | 385.85 | 200 MG
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Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. This sulfonamide agent targets the G1 phase of the cell cycle, causing a blockade in the G1/S transition. It achieves this by inhibiting the activation of both CDK2 and cyclin E. Additionally, it targets splicing by inducing RBM39 degradation via recruitment to DCAF15.
- Carbonic anhydrase inhibitor
- Exhibits anticancer activity
- Sulfonamide agent
- Targets G1 phase of the cell cycle
- Inhibits CDK2 and cyclin E activation
- Induces RBM39 degradation
- Involved in splicing modulation
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Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG
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HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG
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Medchemexpress LLC Cilazapril monohydrate | 92077-78-6 | MFCD00865788 | 99.9% | C22H33N3O6 | 100 MG
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Cilazapril monohydrate is an orally active prodrug of the angiotensin-converting enzyme (ACE) inhibitor Cilazaprilat. It functions by reducing plasma ACE activity. This compound can be utilized in the research of hypertension, including essential and renal hypertension, and congestive heart failure.
- Orally active prodrug of an ACE inhibitor
- Reduces plasma ACE activity
- Used in research of hypertension (essential and renal)
- Used in research of congestive heart failure
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Medchemexpress LLC Linifanib | 796967-16-3 | 99.4% | C21H18FN5O | 200 MG
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Linifanib (ABT-869) is a potent, orally active, multi-target inhibitor of the VEGFR and PDGFR family. It demonstrates prominent antitumor activity and has significantly less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib also acts as a specific miR-10b inhibitor, blocking miR-10b biogenesis.
- Potent and orally active multi-target inhibitor of VEGFR and PDGFR family
- Exhibits prominent antitumor activity
- Significantly less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases
- Acts as a specific miR-10b inhibitor, blocking miR-10b biogenesis
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![Medchemexpress LLC 9H-Purin-6-amine, 9-(1-methylethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]- | 1353867-91-0 | 99.8% | 335.33 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387553-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 9H-Purin-6-amine, 9-(1-methylethyl)-N-[[3-(trifluoromethyl)phenyl]methyl]- | 1353867-91-0 | 99.8% | 335.33 | 200 MG
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Longdaysin is an inhibitor of the Wnt/β-catenin signaling pathway, exerting antitumor effects by blocking CK1δ/ε-dependent Wnt signaling. It inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of 5.6 μM, 8.8 μM, 29 μM, and 52 μM, respectively.
- Inhibitor of the Wnt/β-catenin signaling pathway.
- Exerts antitumor effects by blocking CK1δ/ε-dependent Wnt signaling.
- Inhibits CK1α, CK1δ, CDK7, and ERK2.
- Lengthens circadian period in adult tail fibroblasts, lung explants, and SCN explants.
- Inhibits colony formation, migration, invasion, and sphere formation of breast cancer cells.
- Increases circadian period in zebrafish.
- Inhibits tumor growth in xenograft mice.
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Apexbio Technology LLC 17-AAG (KOS953) 75747-14-7 200mg
17-AAG (KOS953) is a synthetic derivative of geldanamycin that inhibits heat shock protein 90 (HSP90) It acts by binding to HSP90 causing destabilization of client proteins including HER2 Raf-1 p53 and components of MAPK signaling pathways Reported IC50 for 17-AAG in BT474 cells is approximately 6 nM Its biological activity has been investigated broadly including in multiple myeloma breast cancer thyroid cancer Hodgkin lymphoma and melanoma cellular models Ongoing studies explore 17-AAG both as monotherapy and in combination with agents like bortezomib or trastuzumab for addressing treatment-resistant cancer cell lines Currently 17-AAG is evaluated in Phase II clinical trials
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Apexbio Technology LLC ML324 1222800-79-4 200mg
ML324 (CAS 1222800-79-4) is a small-molecule inhibitor targeting JMJD2 histone demethylase enzymes It is designed to suppress JMJD2-mediated demethylation of histone H3 lysine 9 (H3K9) thereby affecting gene transcription regulation ML324 exerts its biological activity primarily through inhibition of JMJD2 demethylases In cell-based studies ML324 inhibits JMJD2 activity displaying an IC50 value of 920 nM In experimental models including HFF and MRC-5 cell lines it blocks immediate-early (IE) gene expression of HSV and hCMV reduces viral spread and plaque formation and inhibits HSV-1 reactivation and replication in latent infection models such as mouse neuronal ganglia explants Based on these pharmacological properties ML324 holds research potential in chromatin remodeling and antiviral therapeutic strategies
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Medchemexpress LLC Transtorine 200mg
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Transtorine is a quinoline alkaloid found from Ephedra transitoria with antibacterial activity[1]
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Medchemexpress LLC NCT-503 | 1916571-90-8 | 99.7% | 408.48 g/mol | C20H23F3N4S | 200 MG
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NCT-503 is a small-molecule inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 2.5 μM, used as a research tool to probe serine biosynthesis pathways and PHGDH-dependent cancer biology in vitro and in vivo.
- Potent PHGDH inhibition with IC50 2.5 μM.
- High selectivity against other dehydrogenases and minimal GPCR cross-reactivity.
- Demonstrated activity in PHGDH-dependent cell lines and tumor xenograft models.
- Solid form with high purity suitable for biochemical and cellular assays.
- Recommended storage conditions for long-term stability.
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Medchemexpress LLC Amisulpride | 71675-85-9 | MFCD00866691 | 99.8% | C17H27N3O4S | 200 MG
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Amisulpride is a racemic (50:50) mixture of R-Amisulpride and S-Amisulpride. It acts as a dopamine D2/D3 receptor antagonist with Ki values of 2.8 nM for human dopamine D2 and 3.2 nM for human dopamine D3 receptors. Amisulpride also functions as a 5-HT7 receptor antagonist with a Ki of 44 nM, making it suitable for use in psychiatric research.
- Racemic mixture
- Dopamine D2/D3 receptor antagonist
- 5-HT7 receptor antagonist
- Suitable for psychiatric research
- D3 receptor Ki: 3.2 nM
- Human D2 receptor Ki: 2.8 nM
- 5-HT7 receptor Ki: 44 nM
- Inhibits quinpirole-elicited [3H]thymidine incorporation
- Increases dopamine release from rat striatum slices
- Increases dopamine synthesis in rat striatum and limbic system
- Increases extracellular dopamine levels
- Decreases striatal ACh levels
- Increases duration of swimming behavior
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