Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Tolmetin sodium dihydrate | 64490-92-2 | 99.94% | 1 ML
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Tolmetin sodium dihydrate is an orally active and potent COX inhibitor, with IC50s of 0.35 μM and 0.82 μM for human COX-1 and COX-2, respectively. It is a non-steroidal anti-inflammatory drug (NSAID).
- Orally active and potent COX inhibitor.
- Non-steroidal anti-inflammatory drug (NSAID).
- Shows anticancer activity against HT-29 colon cancer cell line in a dose-dependent manner.
- Can attenuate quinolinic acid (QA)-induced neurotoxicity.
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Ambeed 11bR 8 9 10 11 12 13 14 15Oct
(11bR)-8,9,10,11,12,13,14,15-Octahydro-N,Nbis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine, 1389329-66-1, 98%
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Ambeed tertButyl 1S 3S 3aminocyclop
tert-Butyl ((1S,3S)-3-aminocyclopentyl)carbamate, 645400-44-8, 95%
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Ambeed 5Bromo2methoxypyrimidine
5-Bromo-2-methoxypyrimidine, 14001-66-2, 98%
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Medchemexpress LLC Peg-bis-amine (MW 2000) | 24991-53-5 | 99.4% | (C2H4O)nC4H12N2O | 250 MG
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PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 2000) is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Can be used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- Ligands are for an E3 ubiquitin ligase and a target protein
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 25 MG
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Benzyl-PEG5-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are molecules with two ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC Amino-PEG9-amine | 474082-35-4 | >98% | C20H44N2O9 | 250 MG
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Amino-PEG9-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds employ the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This mechanism involves two distinct ligands, connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other binds to the protein of interest.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Applicable in targeted therapy drug development
- For research use only
- Molecular weight of 456.57
- Store at 4°C, protect from light. In solvent: store at -80°C for 6 months, or -20°C for 1 month (protect from light).
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Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 250 MG
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Benzyl-PEG5-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. They leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Used in PROTAC synthesis
- PEG-based linker
- Facilitates selective protein degradation
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Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | 97.0% | C22H46N4O10 | 50 MG
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Azido-PEG10-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, which can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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Medchemexpress LLC Azido-PEG23-amine | 2172677-19-7 | 99.93% | C48H98N4O23 | 50 MG
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Azido-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an azide group that enables various cycloaddition reactions.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
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Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 1 G
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Benzyl-PEG5-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It has a molecular weight of 327.42, appears as a liquid, and is colorless to light yellow.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight of 327.42
- Liquid appearance
- Colorless to light yellow
- Purity of 98.0%
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Medchemexpress LLC mPEG-amine (MW 10000) | 80506-64-5 | 637448 | 98.0% | (C2H4O)nC3H9NO | 100 MG
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mPEG-amine (MW 10000), also known as mPEG-NH2 (MW 10000), is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase and the other targets a specific protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Enables selective protein degradation
Average molecular weight of 10000
Appears as a white to off-white solid
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Medchemexpress LLC Poly(oxy-1,2-ethanediyl), α-(2-aminoethyl)-ω-methoxy- | 80506-64-5 | 98.0% | (C2H4O)nC3H9NO | 50 MG
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mPEG-amine (MW 20000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. These compounds exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Useful in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC Mpeg-amine (MW 2000) | 80506-64-5 | 99.6% | (C2H4O)nC3H9NO | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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mPEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Acts as a PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Suitable for biochemical assay reagents
- Applicable in drug delivery
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Medchemexpress LLC Amino-PEG9-amine | 474082-35-4 | >98% | C20H44N2O9 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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