Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,821 – 2,835 of 4,473 results

2,821

Medchemexpress LLC 4h-1-Benzopyran-4-one, 6-[3-(4-morpholinyl)propyl]-2-thieno[3,2-c]pyridin-6-yl-, oxime, hydrochloride | 2133294-96-7 | 98.6% | 457.97 | 25 MG

Foliglurax monohydrochloride is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 79 nM. It exhibits an antiparkinsonian effect and is for research use only.

Highly selective and potent mGluR4 PAM.
Brain-penetrant.
Exhibits an antiparkinsonian effect.
For research use only.
Potentially revolutionizing mGlu4 receptor drug targeting in CNS disorders.

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2,822

Medchemexpress LLC N-[2-[4-[3-(propan-2-ylamino)-2-pyridinyl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide | 136817-59-9 | MFCD00871405 | >98.0% | 456.56 g/mol | C22H28N6O3S | 200 MG

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) supplied as a research-standard chemical for biochemical and pharmacological studies. It corresponds to CAS 136817-59-9, has molecular formula C22H28N6O3S, and a molecular weight of 456.56 g/mol. Common applications include assay development, reference standards, and mechanistic studies.

High chemical purity (>98%).
Suitable for analytical and research use.
Provided as a solid for easy handling and storage.
Applicable for biochemical assay and method development.
Documented identity with CAS and spectral data available.

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2,823

Medchemexpress LLC Zm241385 | 139180-30-6 | 99.5% | 337.34 | 200 MG

Zm241385 | 139180-30-6 | 99.5% | 337.34 | 200 MG

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2,824

Medchemexpress LLC Alpha-Cypermethrin | 67375-30-8 | 99.7% | 200 MG

Alpha-Cypermethrin is an effective insecticide, demonstrated to be active against house flies. This compound is also being investigated in clinical trials for conditions such as Malaria, suggesting potential applications in vector control. It is presented as a white to off-white solid with a high purity of 99.66%.

Purity: 99.66%
Appearance: Solid
Color: White to off-white
Molecular weight: 416.30
Formula: C22H19Cl2NO3
Shipping conditions: Room temperature (in continental US; may vary elsewhere)
Storage conditions for powder: -20°C for 3 years, 4°C for 2 years
Storage conditions in solvent: -80°C for 6 months, -20°C for 1 month

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2,825

Medchemexpress LLC Octisalate | 118-60-5 | 98.0% | 200 MG

Octisalate is an organic compound with high lipophilicity, primarily used in sunscreens and cosmetics for its ability to absorb UVB rays. This product is intended for research use only.

Used in sunscreens and cosmetics for absorbing UVB rays.
Features high lipophilicity.
Soluble in DMSO at 100 mg/mL, requiring ultrasonic.
Shows an average total absorption of skin permeation of 0.65% in vitro.
Stable under recommended storage conditions.

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2,826

Medchemexpress LLC Mivavotinib monohydrochloride | 1952251-28-3 | 99.9% | 380.85 g/mol | C17H22ClFN6O | 5 MG

Mivavotinib monohydrochloride is an investigational small-molecule dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), supplied as a white to off-white solid for research use. The monohydrochloride salt displays low-nanomolar inhibitory activity against SYK and FLT3 and is provided with high purity for preclinical studies.

Dual SYK/FLT3 inhibitor for preclinical research.
High purity (99.9%).
White to off-white solid formulation.
Provided as a monohydrochloride salt for improved stability.
Low-nanomolar potency against target kinases.
Store at 4°C and protect from moisture for long-term stability.

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2,827

Apexbio Technology LLC Tubastatin A HCl 1310693-92-5 200mg

Tubastatin A HCl (CAS 1310693-92-5) is a selective inhibitor of histone deacetylase 6 (HDAC6) exhibiting an IC50 of approximately 15 nM HDAC6 is involved in diverse cellular processes including transcriptional regulation cell cycle progression and neuronal development dysregulated HDAC6 activity is implicated in conditions such as Alzheimer s disease and cancer In primary cortical neuron models Tubastatin A HCl at concentrations of 5 10 M confers protection against neuronal toxicity caused by homocysteic acid In HaCaT cells its HDAC6-specific inhibition prevents arsenite-induced association of Nrf2 mRNA with ribosomes and subsequent protein translation Tubastatin A HCl also enhances cell elasticity by modulating HDAC6-mediated cytoskeletal dynamics

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2,828

Medchemexpress LLC N-allyl-6-bromoquinazolin-4-amine | 307538-42-7 | MFCD02166825 | 99.9% | 264.12 | C11H10BrN3 | 200 MG

SMER28 is a small-molecule positive regulator of autophagy that operates via an mTOR-independent mechanism and has been reported to reduce accumulation of amyloid beta peptide. It is supplied as a research reagent in solid and solution forms for use in cellular and biochemical studies.

Positive regulator of autophagy via an mTOR-independent pathway.
Reported to prevent accumulation of amyloid beta peptide.
Suitable for in vitro cellular and biochemical autophagy studies.
Available in multiple package formats including solid and DMSO solution for assay flexibility.
Characterized by a defined molecular formula and molecular weight for reproducible experiments.

Pricing & Availability

2,829

Medchemexpress LLC B-AP15 | 1009817-63-3 | 98.1% | 419.39 | 200 MG

B-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14. It is for research use only.

Inhibits UCHL5 and Usp14 deubiquitinating enzymes
Induces tumor cell apoptosis
Available as a solid, light yellow to yellow appearance
Formula: C22H17N3O6

Pricing & Availability

2,830

Medchemexpress LLC Everolimus | 159351-69-6 | MFCD00929329 | 99.7% | 958.22 g/mol | C53H83NO14 | 200 MG

Everolimus is a rapamycin-derivative mTORC1 inhibitor used in research to modulate cell growth, proliferation, autophagy, and immune responses. It binds FKBP12 to form an inhibitory complex with mTOR and is commonly used in cellular and preclinical studies.

Potent, selective mTORC1 inhibitor.
Binds FKBP12 to form an inhibitory complex with mTOR.
High purity reported (99.74%).
Available in multiple research pack sizes up to 100 mg and as a 10 mM solution.
Intended for research and analytical applications.

Pricing & Availability

2,831

Medchemexpress LLC Recombinant cynomolgus B7-H2/ICOSLG (His-tag) | 50 UG

Recombinant extracellular domain of cynomolgus B7-H2/ICOSLG, expressed in HEK293 and supplied as a C-terminal His-tagged protein for research use in immunology and binding studies. Supplied as a lyophilized powder with QC data supporting interaction with human ICOS by SPR.

Expressed in HEK293 mammalian cells, preserving native glycosylation
C-terminal His tag for purification and detection
Amino acid range M1-T256; accession XP_005548617.1
Molecular weight approximately 50-70 kDa
Lyophilized from PBS, pH 7.4, for convenient storage
Endotoxin level <1 EU/μg as determined by LAL
Reconstitute to ≥100 μg/mL in ddH2O; aliquot and freeze for long-term storage
Validated binding to human ICOS by SPR (KD 5.42 nM)

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2,832

Apexbio Technology LLC PIK-294 900185-02-6 200mg

PIK-294 (CAS 900185-02-6) is a potent and highly selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) isoform p110 with an IC50 of 10 nM It exhibits substantially reduced activity against PI3K PI3K and PI3K demonstrating a 1 000-fold 49-fold and 16-fold lower potency respectively Biochemical studies indicate that PIK-294 interacts with a high-affinity pocket in the ATP-binding site contributing to its inhibitory properties in vitro Used as a chemical probe PIK-294 aids in delineating isoform-specific PI3K functions such as the distinct roles of PI3K isoforms in insulin signaling and cellular differentiation pathways No clinical studies have been reported

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2,833

Medchemexpress LLC SCH772984 | 942183-80-4 | 99.8% | C33H33N9O2 | 200 MG

SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 nM for ERK1 and 1 nM for ERK2. It exhibits antitumor activity in both MAPK inhibitor-naive and MAPK inhibitor-resistant cells that contain BRAF or RAS mutations.

Highly selective and ATP-competitive ERK inhibitor
Exhibits antitumor activity in MAPK inhibitor-naive and resistant cells
Induces G1 arrest and apoptosis in sensitive melanoma cells
Inhibits ERK and RSK phosphorylation
Shows EC50 values less than 500 nM in BRAF-mutant and RAS-mutant tumor lines
Leads to significant tumor regression in animal models
Well tolerated in vivo

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2,834

Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 200mg

Regorafenib monohydrate (CAS 1019206-88-2) is a multitargeted tyrosine kinase inhibitor that suppresses numerous intracellular and membrane receptor tyrosine kinases (RTKs) including VEGFR (types 1-3) PDGFR- FGFR-1 RET TIE2 c-KIT Raf-1 and BRAF (wild-type and V600E mutant) It inhibits angiogenic RTKs such as VEGFR-2 with IC50 values ranging from approximately 4 2 to 46 nM and oncogenic RTKs like c-KIT and RET with IC50 values around 1 5 to 28 nM Regorafenib demonstrates antiproliferative activity in vitro (mean IC50 1 M) and reduces tumor progression in xenograft animal models supporting its use in cancer research involving breast colorectal thyroid pancreatic cancers melanoma and gastrointestinal stromal tumors

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2,835

TARGETMOL CHEMICALS INC LY2940094 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective selective and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). purity: 99%

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Quinolines and derivatives

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Medchemexpress LLC 4h-1-Benzopyran-4-one, 6-[3-(4-morpholinyl)propyl]-2-thieno[3,2-c]pyridin-6-yl-, oxime, hydrochloride | 2133294-96-7 | 98.6% | 457.97 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Zm241385 | 139180-30-6 | 99.5% | 337.34 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alpha-Cypermethrin | 67375-30-8 | 99.7% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Octisalate | 118-60-5 | 98.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mivavotinib monohydrochloride | 1952251-28-3 | 99.9% | 380.85 g/mol | C17H22ClFN6O | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Tubastatin A HCl 1310693-92-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-allyl-6-bromoquinazolin-4-amine | 307538-42-7 | MFCD02166825 | 99.9% | 264.12 | C11H10BrN3 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC B-AP15 | 1009817-63-3 | 98.1% | 419.39 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Everolimus | 159351-69-6 | MFCD00929329 | 99.7% | 958.22 g/mol | C53H83NO14 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Recombinant cynomolgus B7-H2/ICOSLG (His-tag) | 50 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC PIK-294 900185-02-6 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SCH772984 | 942183-80-4 | 99.8% | C33H33N9O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC LY2940094 5MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More