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Filtered Search Results
Medchemexpress LLC Endothelin-1 (1-31) (Human) | 133972-52-8 | 99.7% | 3628.16 | 1 MG
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Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent derived from the selective hydrolysis of big ET-1 by chymase. In vitro, it induces human mesangial cell proliferation and ERK activation. In vivo, it induces contraction in the mouse mesenteric artery, possibly mediated by the ETA receptor. This contraction can be increased by aging, and gender differences have been observed in chronic diabetic conditions.
- Potent vasoconstrictor.
- Hypertensive agent.
- Derived from selective hydrolysis of big ET-1 by chymase.
- Induces human mesangial cell proliferation and ERK activation in vitro.
- Induces contraction in mouse mesenteric artery in vivo.
- Possible ETA receptor mediation.
- Effects can be increased by aging.
- Gender differences observed in chronic diabetic conditions.
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![eMolecules 3945-69-5 | 4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride | Chem-Impex | MFCD03613550 | 276.720 | C10H17ClN4O3 | 99.000 | [Cl-].COc1nc(OC)nc(n1)[N+]1(C)CCOCC1 | 1kg | 570604846](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules 3945-69-5 | 4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride | Chem-Impex | MFCD03613550 | 276.720 | C10H17ClN4O3 | 99.000 | [Cl-].COc1nc(OC)nc(n1)[N+]1(C)CCOCC1 | 1kg | 570604846
4-(4,6-Dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride | Chem-Impex | 3945-69-5 | MFCD03613550 | 276.720 | C10H17ClN4O3 | 99.000 | [Cl-].COc1nc(OC)nc(n1)[N+]1(C)CCOCC1 | 1kg | 570604846
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Apexbio Technology LLC R 59-022 93076-89-2 10mg
R 59-022 (CAS 93076-89-2) is a small molecule inhibitor of diacylglycerol kinase (DGK) demonstrating an IC50 of 2 8 M for DGK activity By inhibiting the conversion of 1-oleoyl-2-acetylglycerol to phosphatidic acid R 59-022 modulates diacylglycerol signaling pathways The compound also exhibits antagonistic effects at serotonin (5-HT) receptors and can induce activation of protein kinase C (PKC) In cellular studies R 59-022 enhances thrombin-induced diacylglycerol accumulation in platelets and suppresses phosphatidic acid formation in neutrophils It serves as a valuable tool for investigating DGK-mediated processes and signal transduction mechanisms
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Medchemexpress LLC HSGN-94 | 2570797-85-0 | 508.51 | 50 MG
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HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.
- Potent antimicrobial agent with LTA biosynthesis inhibition.
- Inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL.
- Inhibits biofilm formation in MRSA and Vancomycin-resistant Enterococci.
- Inhibits pro-inflammatory cytokines.
- Directly binds to PgsA.
- Downregulates the expression level of PgsA, an essential protein for phospholipid synthesis.
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Medchemexpress LLC (S,R,S)-AHPC-amido-C7-acid | 2172819-76-8 | 98.7% | 600.77 | 25 MG
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(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker, making it suitable for PROTAC development and research applications.
- Incorporates a VHL ligand and a PROTAC linker
- Suitable for research applications
- Designed for PROTAC development
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Medchemexpress LLC Methyl 3,3-dimethoxypropionate | 7424-91-1 | MFCD00010650 | ≥98.0% | 148.16 g/mol | C6H12O4 | 1,000 G
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Methyl 3,3-dimethoxypropionate is a small organic ester used as a biochemical reagent and synthetic building block. It functions as a protected methyl ester derivative of 3-hydroxypropionic acid, suitable for use in organic synthesis and life-science research, and is supplied at high purity for laboratory applications.
- High purity suitable for research applications.
- Molecular weight 148.16 g/mol and formula C6H12O4.
- Useful as a protected ester intermediate in synthetic chemistry.
- Available in multiple packaging sizes for lab-scale use.
- Supplied for research use in laboratory environments.
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Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 1 ML
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LM11A-31 dihydrochloride is a non-peptide modulator of p75NTR (neurotrophin receptor p75) and an orally active, potent antagonist of proNGF (nerve growth factor). This amino acid derivative demonstrates high blood-brain barrier permeability, effectively blocking p75-mediated cell death. It has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease at mid- to late-stage progression.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative
- High blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
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Medchemexpress LLC Bay 59-9435 | 654059-21-9 | 99.8% | 266.34 g·mol⁻¹ | C14H22N2O3 | 25 MG
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BAY 59-9435 is a potent, selective small-molecule inhibitor of hormone-sensitive lipase (HSL) with a reported IC50 of 0.023 μM. It is used as a research tool to study HSL-dependent lipolysis in cellular and animal models. Not for human or clinical use.
- Potent, selective inhibition of hormone-sensitive lipase.
- Low IC50 (0.023 μM) enabling submicromolar activity.
- High purity suitable for biochemical and cellular assays (99.8%).
- Characterized chemical profile (C14H22N2O3; MW 266.34 g·mol⁻¹).
- Convenient small pack size for preclinical research (25 mg).
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Cayman Chemical 4-HydroxyquInolIn 25g
A quinoline alkaloid; is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules; has been used as a precursor in the synthesis of compounds with antibacterial activity; has been used as a fluorescent detection reagent for iron(III) in bovine liver samples
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Apexbio Technology LLC IAA-94 54197-31-8 10mg
IAA-94 (CAS 54197-31-8) is a small-molecule inhibitor of epithelial chloride channels modulating cellular electrophysiological properties by disrupting chloride ion transport Experimental studies have demonstrated that IAA-94 can interfere with interactions involving the negative factor (Nef) protein during infection indicating its capacity to modulate Nef-mediated processes Due to its specificity in targeting chloride channels IAA-94 is widely utilized in investigations of ion channel-related signaling pathways in tumor cells and serves as a valuable tool in studies of cell electrophysiology and infection mechanisms
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Medchemexpress LLC LM11A-31 5mg | 102562-74-3 | 243.35 g/mol | C12H25N3O2 | 5 MG
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LM11A-31 is a small-molecule ligand and modulator of the p75 neurotrophin receptor (p75NTR) used in preclinical research of neurodegenerative diseases. It is orally active, brain-penetrant, and provided for in vitro and in vivo studies in solid and solution formats.
- Small-molecule p75NTR modulator for neurodegeneration research.
- Orally active and brain-penetrant in preclinical studies.
- Available as a solid and as 10 mM solutions in DMSO for convenience.
- Identified by CAS 102562-74-3 and molecular formula C12H25N3O2.
- High reported purity (~99.9%) suitable for research applications.
- Commonly supplied in small research pack sizes such as 5 mg.
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![eMolecules 1612792-88-7 | potassium;[trans-2-ethoxycarbonylcyclopropyl]-trifluoro-boranuide | Pharmablock440.080 | C12H18B2F6K2O4 | 0.000 | [K+].[K+].CCOC(=O)[C@H]1C[C@@H]1[B-](F)(F)F.CCOC(=O)[C@@H]1C[C@H]1[B-](F)(F)F | 100mg | 812213420](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000190574.jpg-250.jpg)
eMolecules 1612792-88-7 | potassium;[trans-2-ethoxycarbonylcyclopropyl]-trifluoro-boranuide | Pharmablock440.080 | C12H18B2F6K2O4 | 0.000 | [K+].[K+].CCOC(=O)[C@H]1C[C@@H]1[B-](F)(F)F.CCOC(=O)[C@@H]1C[C@H]1[B-](F)(F)F | 100mg | 812213420
potassium;[trans-2-ethoxycarbonylcyclopropyl]-trifluoro-boranuide | Pharmablock | 1612792-88-7440.080 | C12H18B2F6K2O4 | 0.000 | [K+].[K+].CCOC(=O)[C@H]1C[C@@H]1[B-](F)(F)F.CCOC(=O)[C@@H]1C[C@H]1[B-](F)(F)F | 100mg | 812213420
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Medchemexpress LLC endo CNTinh-03 | 345288-49-5 | 100.0% | 427.51 | 1 ML
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Inhibitor for the elevation of cAMP and cGMP induced by agonist, such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase (IC50 is 4 μM). It inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current, ameliorates secretory diarrhea in mouse models, and prevents cyst growth in polycystic kidney disease model.
- Inhibitor for the elevation of cAMP and cGMP induced by agonist.
- Inhibits cholera toxin- and Escherichia coli (STa) toxin- induced CFTR chloride current.
- Ameliorates secretory diarrhea in mouse models.
- Prevents cyst growth in polycystic kidney disease model.
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Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 | C31H32N2O8 | 5 G
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5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected uridine analog used as a nucleoside building block and intermediate for the synthesis of modified oligonucleotides. It is supplied as a light-yellow solid with defined purity and storage specifications suited for research and preparative oligonucleotide chemistry.
- DMT protected at the 5' hydroxyl for selective chain assembly.
- 2'-O-methyl modification supports increased nuclease resistance in oligonucleotides.
- High purity material suitable for synthesis and analytical workflows.
- Available in gram-scale pack sizes to accommodate different synthesis scales.
- Stable under recommended storage conditions to preserve quality over time.
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Medchemexpress LLC (S,R,S)-AHPC-amido-C5-acid | 2162120-87-6 | >99.5% | 25 MG
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(S,R,S)-AHPC-amido-C5-acid is a laboratory chemical identified by CAS number 2162120-87-6. It is supplied as a solid and exhibits chemical stability under recommended storage conditions, making it suitable for various research applications.
- Stable under recommended storage conditions.
- Solid appearance.
- Suitable for laboratory chemical applications.
- Recommended storage at -20°C, sealed, away from moisture and light.
- Shipping at room temperature if less than two weeks.
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