Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Cinchonine(LA40221) 118-10-5 25mg
Cinchonine LA40221 (118-10-5) is a small-molecule inhibitor designed to modulate biological processes such as inflammation tumorigenesis malaria infection obesity and platelet aggregation Cinchonine LA40221 exerts its biological activity primarily through regulation of signaling pathways modulation of enzyme activities and induction of apoptosis via caspase-3-dependent mechanisms In in vitro studies Cinchonine LA40221 demonstrates antitumor activity with IC50 values ranging approximately from 10-100 M depending on cell types and protocols Based on these pharmacological properties Cinchonine LA40221 holds research potential in studying malaria infection models cancer cell apoptosis inflammatory responses platelet function and obesity-related metabolic pathways
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AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
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Sigma Aldrich Fine Chemicals Biosciences Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard | 51773-92-3 | MFCD00797519 | 100MG
Mefloquine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 414.77 | 51773-92-3 | MFCD00797519 | 100MG
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Medchemexpress LLC Quinine hydrochloride | 130-89-2 | 99.8% | 360.88 | 10 MG
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Quinine hydrochloride is an alkaloid derived from the bark of the cinchona tree, acting as an anti-malaria agent and potassium channel inhibitor. It inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV.
- Acts as an anti-malaria agent.
- Functions as a potassium channel inhibitor.
- Inhibits WT mouse Slo3 (KCa5.1) channel currents.
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TARGETMOL CHEMICALS INC O-DESMETHYL QUINIDINE 100MG
Also available in 500 mg and bulk. Please contact Fisher for quotes. O-Desmethyl Quinidine is a novel quinidine analog with significant antiarrhythmic activity and low acute toxicity that may be useful in the treatment of cardiac arrhythmias. purity: 100%
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TARGETMOL CHEMICALS INC Quinine dihydrochloride 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). Purity 99.45%
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Medchemexpress LLC Hydroquinine | 1 G
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Hydroquinine | 1 G
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Selleck Chemical LLC Mefloquine HCl S4420-100mg
Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation used as an antimalarial drug
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TARGETMOL CHEMICALS INC Mefloquine 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 uM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research. Purity 99.97%
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Medchemexpress LLC Imiquimod maleate | 896106-16-4 | 99.9% | 100 MG
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Imiquimod maleate is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It demonstrates antiviral and antitumor effects in vivo and is used in research for external genital and perianal warts, cancer, and COVID-19. It appears as a white to off-white solid.
- Molecular weight: 356.38
- Formula: C18H20N4O4
- Ships at room temperature in continental US
- Store at 4°C, sealed, away from moisture
- When in solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO (25 mg/mL) and H2O (2 mg/mL)
- Targets TLR7 and HSV-1
- Used to induce psoriasis models
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Medchemexpress LLC Regorafenib monohydrate | 1019206-88-2 | MFCD17170366 | 99.7% | 500.83 g/mol | C21H17ClF4N4O4 | 5 MG
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Regorafenib monohydrate is the monohydrate form of regorafenib, a multi-targeted receptor tyrosine kinase inhibitor supplied for laboratory research use. The product is provided as a characterized solid with accompanying COA, SDS, and handling documentation. Not for human or veterinary use.
- High purity (LCMS 99.67% reported in COA).
- Molecular weight 500.83 g/mol.
- Molecular formula C21H17ClF4N4O4.
- Off-white to light brown solid with supporting NMR and LCMS data.
- Available in small research sizes and solution formats.
- Supplied with COA, SDS, and storage instructions for research use only.
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TARGETMOL CHEMICALS INC HS-173 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. HS-173 is an effective PI3K(alpha) inhibitor (IC50 0.8 nM). purity: 99%
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Medchemexpress LLC Gilteritinib | 1254053-43-4 | 200MG
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Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0 29 nM/0 73 nM respectively
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Medchemexpress LLC MNS (NSC 170724), 5-(2-nitrovinyl)benzodioxole | 1485-00-3 | 99.55% | C9H7NO4 | 200 MG
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MNS (NSC 170724), a beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. It inhibits Src, Syk, and FAK, and is cytotoxic to various cell types. This compound also inhibits NLRP3 inflammasome and β1 integrin.
- Acts as a tyrosine kinase inhibitor.
- Functions as a broad-spectrum antiplatelet agent.
- Inhibits Src, Syk, and FAK.
- Inhibits NLRP3 inflammasome.
- Inhibits β1 integrin.
- Exhibits cytotoxicity to various cell types.
- Completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation.
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Medchemexpress LLC Z-Leu-Leu-Leu-al | 133407-82-6 | MFCD00674886 | 99.9% | 475.6 | 200 MG
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MG-132 is a potent and reversible proteasome inhibitor with an IC50 of 100 nM. It also acts as a calpain inhibitor with an IC50 of 1.2 μM. It effectively blocks the proteolytic activity of the 26S proteasome complex, acts as an autophagy activator, and induces apoptosis.
- Potent and reversible proteasome inhibitor
- Blocks proteolytic activity of the 26S proteasome complex
- Acts as an autophagy activator
- Induces apoptosis
- Calpain inhibitor
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