Quinolines and derivatives
Medchemexpress LLC EGFR-IN-86 | 3055550-22-3 | 99.9% | 423.49 | 25 MG
EGFR-IN-86 is an EGFR inhibitor with an IC50 of 1.5 nM. It shows high activity against glioblastoma, inducing apoptosis and arresting U87 cell cycles in the G2/M phase. This product is for research use only and not sold to patients.
- Potent EGFR inhibitor
- High activity against glioblastoma
- Induces apoptosis
- Arrests U87 cell cycles in G2/M phase
Medchemexpress LLC CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 1 MG
CLIP (86-100) is a fragment consisting of amino acids 86 to 100 of the class II-associated invariant chain peptide (CLIP). This small self-peptide is a cleavage product of the invariant chain and resides in the HLA-II antigen binding groove, playing a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site.
- Consists of amino acids 86 to 100 of the class II-associated invariant chain peptide
- Plays a critical role in the assembly and transport of MHC class II alphabetaIi complexes
- Purity of 98.49%
- Molecular weight: 1674.10
- White to off-white solid appearance
- Soluble in H2O at ≥ 100 mg/mL
- Store as powder at -80°C for 2 years or -20°C for 1 year
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Oridonin | 28957-04-2 | 99.9% | 364.43 | 200 MG
Oridonin is a diterpenoid isolated from *Rabdosia rubescens*. It acts as an inhibitor of AKT, with IC50s of 8.4 μM for AKT1 and 8.9 μM for AKT2. Oridonin also exhibits anti-tumor, anti-bacterial, and anti-inflammatory effects. It is intended for research use only.
- Inhibits AKT1 (IC50: 8.4 μM) and AKT2 (IC50: 8.9 μM)
- Exhibits anti-tumor effects
- Exhibits anti-bacterial effects
- Exhibits anti-inflammatory effects
Medchemexpress LLC Lificiguat | 170632-47-0 | 99.7% | 304.34 | 200 MG
Lificiguat (YC-1) is a soluble guanylyl cyclase (sGC) activator that binds to the β subunit of sGC. It stimulates sGC activity, especially in the presence of CO or NO, leading to several hundred-fold activation. This compound has also been shown to inhibit tumor growth and improve rodent learning behavior.
- Binds to the β subunit of soluble guanylyl cyclase (sGC)
- Activates sGC, synergistically with carbon monoxide or nitric oxide
- Inhibits tumor growth
- Improves rodent learning behavior
- Enhances long-term potentiation (LTP)
Apexbio Technology LLC U0126 200mg
U0126 (CAS 109511-58-2) is a selective non-ATP competitive inhibitor of the MAPK/ERK kinase (MEK1/2) pathway interfering with downstream ERK1/2 activation By inhibiting MEK1/2 activity U0126 modulates cellular processes including proliferation differentiation and survival Additionally U0126 has been reported to suppress autophagy and mitophagy pathways This compound is widely used in biomedical research to investigate MAPK signaling dynamics as well as to explore the regulation of autophagic and mitochondrial quality control mechanisms in various cell models
eMolecules 101066-61-9 | 2-chloropyridine-4-carbaldehyde | Pharmablock | MFCD06651557 | 141.550 | C6H4ClNO | 97.000 | Clc1cc(C=O)ccn1 | 2.5g | 686925096
2-chloropyridine-4-carbaldehyde | Pharmablock | 101066-61-9 | MFCD06651557 | 141.550 | C6H4ClNO | 97.000 | Clc1cc(C=O)ccn1 | 2.5g | 686925096
Apexbio Technology LLC Nifuroxazide 965-52-6 200mg
Nifuroxazide (CAS 965-52-6) is a small-molecule inhibitor targeting signal transducer and activator of transcription (STAT) signaling pathways It is designed to inhibit activation of STAT1 STAT3 and STAT5 thereby suppressing cytokine-mediated transcriptional activities Nifuroxazide exerts its biological activity primarily through inhibition of STAT phosphorylation and activation In cell-based assays Nifuroxazide demonstrates inhibitory activity with an IC50 value of approximately 3 M against STAT3 phosphorylation and activation in IL-6-stimulated U3A cells Based on these pharmacological properties Nifuroxazide holds research potential in studies of STAT-driven signaling processes and in exploring therapeutic strategies for diseases associated with aberrant cytokine signaling and STAT pathway activation
Apexbio Technology LLC Pramiracetam 68497-62-1 200mg
Pramiracetam (CAS 68497-62-1) is a small-molecule inhibitor targeting prolyl endopeptidase It is designed to modulate this enzyme thereby influencing neurochemical processes involved in cognitive function Pramiracetam exerts its biological activity primarily through inhibition of prolyl endopeptidase In animal studies pramiracetam demonstrates the ability to modulate cortical nitric oxide synthase (NOS) activity particularly with lithium chloride pretreatment Based on these pharmacological properties pramiracetam holds research potential in the investigation of cognitive impairment following brain injury and in studies of neurodegenerative diseases
Medchemexpress LLC Paeoniflorin | 23180-57-6 | 98.9% | 480.46 | 200 MG
Paeoniflorin is a heat shock protein-inducing compound commonly found in plants of the Paeoniaceae family. It exhibits diverse biological activities, making it suitable for various research applications.
- Exhibits anticancer activity
- Has anti-inflammatory properties
- Enhances cognition and attenuates learning impairment
- Provides anti-oxidative stress benefits
- Prevents antiplatelet aggregation
- Expands blood vessels
- Reduces blood viscosity
Apexbio Technology LLC PF-543 Citrate 1415562-83-2 200mg
PF-543 Citrate (CAS 1415562-83-2) is a cell-permeable small molecule that functions as a potent and selective inhibitor of sphingosine kinase 1 (SphK1) It acts by competitively inhibiting sphingosine binding exhibiting a K(i) of 3 6 nM for SphK1 and demonstrating over 100-fold selectivity compared to the SphK2 isoform PF-543 Citrate is utilized in research to elucidate the specific contributions of SphK1-mediated sphingosine-1-phosphate (S1P) signaling in cellular and physiological processes
Medchemexpress LLC Diflucortolone valerate | 59198-70-8 | 478.57 | 200 MG
Diflucortolone valerate is a powerful corticosteroid used topically for the research of various skin diseases. It is a potent corticosteroid esterified with valeric acid, which helps reduce swelling, itching, and redness. It is for research use only and not sold to patients. The product appears as a white to off-white solid.
- Powerful corticosteroid
- Used for research of various skin diseases
- Esterified with valeric acid
- Helps reduce swelling, itching, and redness
- Appears as a white to off-white solid
- For research use only
Medchemexpress LLC AT9283 | 896466-04-9 | 99.7% | C19H23N7O2 | 200 MG
AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I), and Flt3 (IC50s 1-30 nM). It has been shown to inhibit the growth and survival of various solid tumors both in vitro and in vivo. This product is intended for research use only.
- Potent multi-targeted kinase inhibitor
- Active against Aurora A/B, JAK2/3, Abl (T315I), and Flt3
- Inhibits growth and survival of various solid tumors
- Induces polyploid phenotype and apoptosis in certain cancer cell lines
- Shows significant tumor growth inhibition in xenograft models
- Enhances survival in mouse xenograft models of mantle cell lymphoma
eMolecules 72716-87-1 | 2-Methoxy-pyridine-4-carbaldehyde | Ochem Incorporation | MFCD06410680 | 137.138 | C7H7NO2 | 98.000 | COc1cc(C=O)ccn1 | 1g | 773157178
2-Methoxy-pyridine-4-carbaldehyde | Ochem Incorporation | 72716-87-1 | MFCD06410680 | 137.138 | C7H7NO2 | 98.000 | COc1cc(C=O)ccn1 | 1g | 773157178
eMolecules 90905-32-1 | 2-METHOXYPYRIMIDINE-5-CARBALDEHYDE | AstaTech | MFCD03446732 | 138.126 | C6H6N2O2 | 95.000 | COc1ncc(C=O)cn1 | 1g | 233617971
2-METHOXYPYRIMIDINE-5-CARBALDEHYDE | AstaTech | 90905-32-1 | MFCD03446732 | 138.126 | C6H6N2O2 | 95.000 | COc1ncc(C=O)cn1 | 1g | 233617971
Apexbio Technology LLC Rocilinostat (ACY-1215) 1316214-52-4 200mg
Rocilinostat (ACY-1215 CAS 1316214-52-4) is a selective inhibitor of histone deacetylase 6 (HDAC6) HDAC6 enzymatically regulates various cellular processes including protein trafficking cell-cycle progression and cytoskeletal organization and its dysregulated activity is implicated in tumor progression and cancer metastasis Rocilinostat potently inhibits HDAC6 (IC50 5 nM) while showing minimal activity against other HDAC isoforms and sirtuins (IC50 1 M) Preclinical studies using multiple myeloma (MM) cell lines and xenograft mouse models demonstrated rocilinostat can enhance acetylation of -tubulin disrupt protein stability pathways and sensitize cancer cells to proteasome inhibitors such as bortezomib and carfilzomib resulting in increased apoptosis and reduction in tumor growth