Quinolines and derivatives
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Filtered Search Results
eMolecules Ambeed 3 4-Dimethoxy-2-nitrobenzoic acid 100mg 525226340 A578526 0 000 79025-28-8 MFCD00074884 227 172 C9H9NO6
Ambeed 3 4-Dimethoxy-2-nitrobenzoic acid 100mg 525226340 A578526 0 000 79025-28-8 MFCD00074884 227 172 C9H9NO6
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5000379631 DORSOMORPHIN 200MG
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eMolecules EMOLECULES INC
5000474217 TERT-BUTYL 3R-3-FLUORO-4- 5G
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eMolecules EMOLECULES INC
5000474212 METHYL 2-QUINOLIN-6-YLACE 5G
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5000342802 AMINO-PEG5-AMINE 250MG
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Apexbio Technology LLC CYT387 1056634-68-4 200mg
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CYT387 (CAS 1056634-68-4) is an aminopyrimidine derivative identified through high-throughput screening and optimized with structure-guided medicinal chemistry It functions as an inhibitor targeting Janus kinase family enzymes JAK1 JAK2 JAK3 and TYK2 with reported IC50 values of 11 nM 18 nM 155 nM and 17 nM respectively At concentrations between 500 1500 nM CYT387 selectively suppresses JAK2 signaling inhibits proliferation of JAK2-dependent hematopoietic cell lines and induces apoptosis with minimal effects on non-hematopoietic cells CYT387 is employed in experimental studies of JAK2-mediated signaling pathways and myeloproliferative neoplasms
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Apexbio Technology LLC Resiquimod (R-848) 144875-48-9 100mg
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Resiquimod (R-848) is an immunomodulatory small molecule structurally related to imiquimod It functions primarily by activating immune responses via inducing cytokine release In vitro studies with human peripheral blood mononuclear cells (PBMC) indicate that Resiquimod promotes dose-dependent production of cytokines including interferon-alpha (IFN- ) tumor necrosis factor (TNF) interleukin-1 (IL-1 ) and interleukin-6 (IL-6) Mechanistically Resiquimod increases intracellular IL-1 levels and both monocytes and B-cells respond by secreting IFN upon stimulation In addition it elevates mRNA expression of IFN- TNF and IL-8 in treated PBMC relative to untreated controls Resiquimod demonstrates antiviral and antitumor activities in preclinical animal models frequently utilized as an immune response potentiator and Toll-like receptor (TLR) agonist in biomedical investigations (IC50 values typically range in low micromolar)
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Apexbio Technology LLC Regorafenib hydrochloride(Synonyms: Regorafenib HCl, BAY 73-4506, Stivarga, BAY73-4506 hydrochloride, Regorafenib hydrochloride salt), 200mg, CAS: 835621-07-3.
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Regorafenib hydrochloride (CAS 835621-07-3) is an orally bioavailable small molecule inhibitor targeting multiple protein kinases including c-KIT VEGFR2 and B-Raf It inhibits these kinases with IC50 values of approximately 17 nM (c-KIT) 40 nM (VEGFR2) and 69 nM (B-Raf) By blocking kinase signaling Regorafenib hydrochloride effectively interrupts tumor-associated pathways involved in cell proliferation angiogenesis and survival It is widely used in oncology research for studies focused on kinase-mediated tumor growth and vascularization mechanisms
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Selleck Chemical LLC Cell Counting Kit-8 B34304-25ML
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The Bimake Cell Counting Kit-8 (CCK-8) is a fluorescent assay for the determination of cell viability in vitro Results are obtained in only 3 steps addition incubation and reading
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5000405935 IMIQUIMOD MALEATE 200MG
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eMolecules 7-Bromo-1-methyl-1H-quinoxalin-2-one | 82019-32-7 | MFCD10000855 | 250mg
Ambeed | 7-Bromo-1-methyl-1H-quinoxalin-2-one | 250mg | 600833751 | A206593 | | 82019-32-7 | MFCD10000855 | 239.072 | C9H7BrN2O
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Apexbio Technology LLC SR-9243 1613028-81-1 200mg
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SR-9243 (CAS 1613028-81-1) is a small-molecule inverse agonist targeting liver X receptors (LXRs) nuclear transcription factors involved in metabolic regulation It is designed to induce LXR corepressor interactions thereby suppressing transcriptional activation of glycolytic and lipogenic enzyme genes SR-9243 exerts its biological activity primarily through inhibition of glycolysis- and lipid biosynthesis-associated gene expression In in vitro assays SR-9243 reduces cancer cell viability and induces apoptosis through caspase 3/7 activation in colorectal cancer cell lines Based on these pharmacological properties SR-9243 holds research potential in investigating metabolic reprogramming in cancer particularly in prostate colon and lung cancer models
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5000405658 DESONIDE 200MG
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5000446557 2-AMINOQUINOLINE 5G
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eMolecules EMOLECULES INC
5000473909 2-METHOXYPYRIDINE-4-CARB 250MG
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