Quinolines and derivatives
Medchemexpress LLC N,S-diacetyl-L-cysteine | 18725-37-6 | 99.4% | 200MG
N,S-diacetyl-L-cysteine | 18725-37-6 | 99.4% | 200MG
Apexbio Technology LLC GDC-0449 (Vismodegib) 879085-55-9 200mg
GDC-0449 (Vismodegib CAS 879085-55-9) is a small molecule that selectively inhibits the Hedgehog (Hh) signaling pathway by binding to the Smoothened (SMO) receptor thus preventing downstream activation of Hh target genes implicated in cellular proliferation and differentiation This compound emerged from screening small-molecule libraries followed by medicinal chemistry optimization Preclinical evaluation demonstrated antitumor activity in murine models of medulloblastoma and xenograft models derived from human colon and pancreatic cancers Currently GDC-0449 is under investigation for locally advanced and metastatic solid tumors
Apexbio Technology LLC Procainamide HCl 614-39-1 200mg
Procainamide hydrochloride (CAS 614-39-1) is a small molecule that functions as an inhibitor of DNA methyltransferase 1 (DNMT1) modulating DNA methylation patterns and thereby restoring the expression of tumor suppressor genes This activity has been associated with suppression of cell proliferation and migration as well as the induction of cellular vacuolization Additionally Procainamide hydrochloride has been shown to enhance potassium channel activity contributing to the regulation of smooth muscle relaxation It is commonly employed in biomedical research focused on epigenetic mechanisms in oncology and studies of cardiac arrhythmias
Apexbio Technology LLC LY2608204 1234703-40-2 200mg
LY2608204 (CAS 1234703-40-2) is a small molecule activator of glucokinase (GK) enhancing its activity as indicated by an EC50 of 42 nM under low glucose conditions In the INS1-E rat insulinoma cell line LY2608204 stimulates glucose metabolism with an EC50 of 579 nM Preclinical studies have demonstrated that administration of LY2608204 leads to dose-dependent reductions in both fasting and postprandial blood glucose levels These properties make LY2608204 a valuable tool for investigating GK modulation and its effects on glucose homeostasis in metabolic disease research
Apexbio Technology LLC Oxaliplatin 61825-94-3 200mg
Oxaliplatin (CAS 61825-94-3) is a platinum-based chemotherapeutic agent that functions primarily by forming DNA adducts thereby disrupting DNA synthesis and ultimately inducing apoptosis via primary and secondary DNA damage It demonstrates antitumor activity against various cancer cell lines including melanoma (IC50 0 14 7 85 M) ovarian carcinoma (IC50 0 17 M) bladder cancer (IC50 11 15 M) colon cancer (IC50 2 95 M) and glioblastoma (IC50 17 6 30 9 M) Oxaliplatin is useful in preclinical animal tumor models and has clinical applications notably in metastatic colorectal cancer therapy combined with fluorouracil and folinic acid
Apexbio Technology LLC Evacetrapib (LY2484595) 1186486-62-3 200mg
Evacetrapib (LY2484595 CAS 1186486-62-3) is a potent and selective inhibitor targeting cholesteryl ester transfer protein (CETP) a regulator of lipid metabolism Evacetrapib exhibits inhibitory activity with IC50 values of 5 5 nM in assays containing recombinant human CETP and 26 nM within human plasma CETP assays In vivo oral administration at 30 mg/kg in human CETP/ApoAI double-transgenic mice significantly reduces CETP activity and elevates HDL-cholesterol concentration (ED50 5 mg/kg) Evacetrapib does not elevate blood pressure nor induce aldosterone or cortisol synthesis in model systems highlighting its potential in cardiovascular research related to coronary artery disease
Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 10 MG
Sulfo-GMBS is a water-soluble, heterobifunctional cross-linking reagent containing a sulfo-NHS ester and a maleimide. It enables selective conjugation between primary amines and sulfhydryl groups in aqueous systems, making it suitable for protein and peptide bioconjugation, surface immobilization, and analytical assay development.
- Water-soluble heterobifunctional cross-linker for aqueous reactions.
- Reacts with primary amines via sulfo-NHS ester chemistry.
- Reacts with sulfhydryl groups via maleimide chemistry.
- Suitable for protein and peptide conjugation and surface immobilization.
- Provided in small solid quantities for laboratory-scale use.
- High purity for consistent conjugation performance.
Apexbio Technology LLC WYE-125132 (WYE-132) 1144068-46-1 200mg
WYE-125132 (WYE-132) [CAS 1144068-46-1] is a potent ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) displaying high selectivity over PI3K isoforms It effectively targets both mTORC1 and mTORC2 complexes as demonstrated by inhibition of S6K (T389) and AKT (S473) phosphorylation in immunocomplex assays with an IC50 of 0 19 0 07 nM WYE-125132 suppresses phospho-S6K and phospho-AKT in IGF-I stimulated or mutant cell lines at low nanomolar EC50 values and inhibits proliferation across multiple cancer cell models The compound is widely utilized in research to study mTOR signaling and its role in cellular proliferation and protein synthesis
TARGETMOL CHEMICALS INC Isomaltose 200MG
Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Isomaltose (D-Isomaltose) is a reducing disaccharide, similar to maltose, but with an alpha-(1-6)-linkage instead of the alpha-(1-4)-linkage. Purity 98.27%
![Medchemexpress LLC N-[2-[4-[3-(propan-2-ylamino)-2-pyridinyl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide | 136817-59-9 | MFCD00871405 | >98.0% | 456.56 g/mol | C22H28N6O3S | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241550.png-250.jpg)
Medchemexpress LLC N-[2-[4-[3-(propan-2-ylamino)-2-pyridinyl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide | 136817-59-9 | MFCD00871405 | >98.0% | 456.56 g/mol | C22H28N6O3S | 200 MG
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) supplied as a research-standard chemical for biochemical and pharmacological studies. It corresponds to CAS 136817-59-9, has molecular formula C22H28N6O3S, and a molecular weight of 456.56 g/mol. Common applications include assay development, reference standards, and mechanistic studies.
- High chemical purity (>98%).
- Suitable for analytical and research use.
- Provided as a solid for easy handling and storage.
- Applicable for biochemical assay and method development.
- Documented identity with CAS and spectral data available.
Medchemexpress LLC Vk-II-86 (carvedilol analogue) | 955371-84-3 | 93.3% | 420.50 | C25H28N2O4 | 5 MG
VK-II-86 is a carvedilol analogue and a store-overload-induced calcium release (SOICR) inhibitor used as a research chemical to study cardiac arrhythmia mechanisms and calcium homeostasis. It lacks β-adrenoceptor antagonist activity and has been shown to prevent hypokalaemia-induced ventricular arrhythmia by normalizing ion channel activity and repolarization reserve.
- Inhibits store-overload-induced calcium release, supporting arrhythmia research.
- Lacks β-adrenoceptor antagonist activity, reducing β-blocking confounds in studies.
- Reported to normalize calcium homeostasis and repolarization reserve in models.
- Solid, light brown to brown appearance and supplied in small milligram quantities.
- Molecular weight 420.50 g/mol; formula C25H28N2O4.
- High purity (93.3%) suitable for laboratory research applications.
Medchemexpress LLC N-allyl-6-bromoquinazolin-4-amine | 307538-42-7 | MFCD02166825 | 99.9% | 264.12 | C11H10BrN3 | 200 MG
SMER28 is a small-molecule positive regulator of autophagy that operates via an mTOR-independent mechanism and has been reported to reduce accumulation of amyloid beta peptide. It is supplied as a research reagent in solid and solution forms for use in cellular and biochemical studies.
- Positive regulator of autophagy via an mTOR-independent pathway.
- Reported to prevent accumulation of amyloid beta peptide.
- Suitable for in vitro cellular and biochemical autophagy studies.
- Available in multiple package formats including solid and DMSO solution for assay flexibility.
- Characterized by a defined molecular formula and molecular weight for reproducible experiments.
Medchemexpress LLC Mivavotinib monohydrochloride | 1952251-28-3 | 99.9% | 380.85 g/mol | C17H22ClFN6O | 5 MG
Mivavotinib monohydrochloride is an investigational small-molecule dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), supplied as a white to off-white solid for research use. The monohydrochloride salt displays low-nanomolar inhibitory activity against SYK and FLT3 and is provided with high purity for preclinical studies.
- Dual SYK/FLT3 inhibitor for preclinical research.
- High purity (99.9%).
- White to off-white solid formulation.
- Provided as a monohydrochloride salt for improved stability.
- Low-nanomolar potency against target kinases.
- Store at 4°C and protect from moisture for long-term stability.
Apexbio Technology LLC LY2603618 911222-45-2 200mg
LY2603618 (CAS 911222-45-2) is a small-molecule inhibitor selectively targeting checkpoint kinase 1 (Chk1) an enzyme responsible for orchestrating DNA damage repair pathways It competitively binds Chk1 s ATP-binding domain thereby inhibiting its kinase activity Experimental studies in non-small cell lung cancer cell lines (including A549 and H1299) demonstrated that treatment with LY2603618 induced DNA damage increased -H2AX phosphorylation and resulted in G2/M phase cell cycle arrest In vivo assessments using Calu-6 lung cancer xenograft models indicated enhanced DNA damage response when combined with gemcitabine chemotherapy LY2603618 is employed as a valuable tool in cancer research to explore Chk1 s biological role and evaluate synergistic therapeutic strategies
Apexbio Technology LLC Azelastine HCl 79307-93-0 200mg
Azelastine HCl (79307-93-0) is a small-molecule antagonist targeting the histamine H1 receptor It is designed to inhibit the H1 receptor thereby disrupting histamine-induced inflammatory and allergic pathway signaling Azelastine HCl exerts its biological activity primarily through competitive antagonism of H1 receptors blocking downstream cascades including smooth muscle contraction increased endothelial permeability and inflammatory mediator release In receptor-binding studies Azelastine HCl demonstrates antagonist activity with IC50 values of approximately 1 2 2 5 nM Based on these pharmacological properties Azelastine HCl holds research potential in the investigation of allergy pathogenesis allergic inflammation mechanisms and the evaluation of receptor-specific responses in cellular and animal models