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Filtered Search Results
Medchemexpress LLC Alimemazine hemitartrate | 4330-99-8 | 98.4% | 200 MG
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Alimemazine hemitartrate is an antagonist of the histamine (HA) receptor that also acts as a partial agonist at other GPCR receptors. This compound exhibits anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. It promotes pancreatic β-cell growth and improves diabetes in mice. This product is intended for research use only.
- Acts as a histamine (HA) receptor antagonist
- Functions as a partial agonist at GPCR receptors
- Exhibits anti-serotonin, antispasmodic, and antihistamine properties
- Offers sedative, hypnotic, antiviral, and anti-nausea effects
- Promotes pancreatic β-cell growth
- Improves diabetes in mouse models
- Reduces SARS-CoV-2 induced syncytia formation
- Inhibits SARS-CoV-2 in HEK293T/ACE2 and VeroE6/TMPRSS2 cells
- For research use only
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![Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243212.png-250.jpg)
Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG
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TAK-715 is an orally active, potent p38 MAPK inhibitor used in research to probe p38α signaling and related pathways; it also inhibits casein kinase I (CK1δ/ε) and has demonstrated efficacy in preclinical inflammation models.
- Potent p38α inhibition (IC50 7.1 nM) with reduced activity against p38β (IC50 200 nM).
- Reported inhibition of CK1δ/ε and modulation of Wnt/β-catenin signaling.
- Chemical formula C24H21N3OS; molecular weight 399.51 g/mol.
- High reported purity (99.76%).
- Soluble in DMSO (≈50 mg/mL) with suggested protocols for in vivo formulation.
- Powder stable at -20°C for extended storage; solvent stocks stable at -80°C.
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TARGETMOL CHEMICALS INC ZINC12409120 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 uM.ZINC12409120 inhibits ERK activity by interfering with FGF23(alpha)-Klotho interaction. purity: 99%
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Medchemexpress LLC Argatroban (monohydrate) | 141396-28-3 | 99.6% | 5 MG
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Argatroban (monohydrate) is a direct, selective thrombin inhibitor used for research purposes. It is effective in preventing thrombus formation and has been studied for its use in creating animal models for thrombolysis.
- Suitable for high-speed applications
- Available in solid form
- Used to inhibit thrombin activity in animals
- Has potential for preventing thrombus formation without aggravating bleeding
- Can enhance reperfusion with TPA in patients with AMI
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TARGETMOL CHEMICALS INC LEMINOPRAZOLE 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Leminoprazole is an orally available H+K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages. purity: 99%
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Ambeed 2Bromonaphthalene
2-Bromonaphthalene, 580-13-2, 98%
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Apexbio Technology LLC GI-530159 69563-88-8 200mg
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GI-530159 (CAS 69563-88-8) is a small molecule activator selective for the TREK1 and TREK2 two-pore domain potassium channels exhibiting greater specificity for TREK1/2 over other related channels such as TRAAK and TASK3 It has been shown to potentiate TREK1 channel activity with an EC50 of 0 76 M In experimental models GI-530159 reduces excitability in rat dorsal root ganglion neurons indicating its capability to modulate neuronal activity These properties highlight its utility as a pharmacological tool in studies related to neuronal excitability pain pathways and the pathophysiology of neurological disorders involving potassium channel dysfunction
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Apexbio Technology LLC NSC 74859 501919-59-1 200mg
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NSC 74859 (CAS 501919-59-1) also known as S3I-201 is a selective inhibitor of the signal transducer and activator of transcription 3 (Stat3) pathway S3I-201 disrupts Stat3 DNA-binding activity exhibiting an IC50 of 86 M in vitro with minimal inhibitory effects on Stat1 and Stat5 It also impedes the formation of Stat1-Stat3 and Stat1-Stat1 complexes with IC50 values of 160 M and 300 M respectively In NIH 3T3/v-Src fibroblasts S3I-201 reduces constitutive Stat3 activation and pTyr-705 Stat3 levels induces apoptosis at 30 100 M and downregulates cyclin D1 Bcl-xL and survivin expression This compound is widely utilized in research to interrogate Stat3 function in cellular transformation and oncogenic signaling pathways
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Apexbio Technology LLC Tempo 2564-83-2 200mg
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Tempo (CAS 2564-83-2) is a stable nitroxide radical widely employed in biomedical research for its redox-active properties It facilitates the dismutation of superoxide radicals thereby modulating mitochondrial reactive oxygen species (ROS) levels and influencing cellular oxidative stress responses Tempo also serves as an oxidation catalyst particularly in the transformation of primary alcohols to aldehydes Studies indicate that Tempo exerts both antioxidant and mutagenic effects inducing DNA strand breaks and displaying cytotoxic and mutagenic activities in in vitro models such as murine lymphoma cells It is utilized for investigating oxidative stress redox regulation and chemical mutagenesis
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Apexbio Technology LLC Fingolimod (FTY720) 162359-56-0 200mg
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Fingolimod (FTY720 CAS 162359-56-0) is an orally administered sphingosine-1-phosphate (S1P) receptor agonist structurally analogous to natural sphingosine Originally derived from fungal metabolites and initially investigated in organ transplantation fingolimod interacts potently with receptors S1P1 S1P3 S1P4 and S1P5 (EC50 values approximately 0 3 3 1 nM) Its agonism promotes receptor internalization suppressing lymphocyte migration from lymph nodes into the circulation and central nervous system (CNS) Thus fingolimod is studied primarily for autoimmune disorders especially multiple sclerosis due to its effects on lymphocyte trafficking and CNS infiltration
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Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg
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Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments
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Apexbio Technology LLC PF-543 1415562-82-1 200mg
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PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking
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Medchemexpress LLC Tirapazamine | 27314-97-2 | 99.0% | 178.15 | 200 MG
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Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single- and double-strand breaks in DNA, base damage, and cell death. It is an anticancer and bioreductive agent that can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.
- Selective cytotoxicity for hypoxic cells
- Induces single- and double-strand breaks in DNA
- Induces base damage and cell death
- Enhances cytotoxic effects of ionizing radiation in hypoxic cells
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Sigma Aldrich Fine Chemicals Biosciences 8-Quinolinol N-oxide 98% | 1127-45-3 | MFCD00006739 | 10G
8-Quinolinol N-oxide 98% | Purity: 98% | Mol Wt: 161.16 | 1127-45-3 | MFCD00006739 | 10G
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Medchemexpress LLC Eltrombopag | 496775-61-2 | MFCD20926253 | C25H22N4O4 | 200 MG
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Eltrombopag is an orally active thrombopoietin receptor nonpeptide agonist. It exhibits thrombopoietic activity and has been studied for low blood platelet counts in chronic immune thrombocytopenia. It is also used in cardiovascular research, shows strong inhibitory effects against multidrug-resistant Staphylococcus aureus, and can induce apoptosis in hepatocellular carcinoma (HCC).
- Exhibits thrombopoietic activity
- Used in research for low blood platelet counts in chronic immune thrombocytopenia
- Utilized in cardiovascular research
- Shows strong inhibitory effects against multidrug-resistant Staphylococcus aureus
- Can induce apoptosis in hepatocellular carcinoma (HCC)
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