Quinolines and derivatives
Medchemexpress LLC Selumetinib | 606143-52-6 | 99.6% | C17H15BrClF4O3 | 200 MG
Selumetinib is a selective, non-ATP-competitive oral MEK1/2 inhibitor with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier. This compound causes a time- and dose-dependent reduction in DNA synthesis and cell viability, inducing growth arrest and apoptosis associated with ERK inactivation.
- Selective, non-ATP-competitive oral MEK1/2 inhibitor
- Inhibits ERK1/2 phosphorylation
- Penetrates the blood-brain barrier
- Induces growth arrest and apoptosis
- Shows anti-proliferative effects
![Medchemexpress LLC N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide | 93515-00-5 | MFCD00055216 | 99.0% | 358.17 | C13H15IN2O2 | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211247.png-250.jpg)
Medchemexpress LLC N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide | 93515-00-5 | MFCD00055216 | 99.0% | 358.17 | C13H15IN2O2 | 200 MG
2-Iodomelatonin is a halogenated melatonin analogue supplied as a research reagent and analytical standard. It acts as a high-affinity agonist at melatonin receptor 1 (MT1) with marked selectivity over MT2, and is used to identify, characterize, and localize melatonin binding sites in neural and peripheral tissues.
TARGETMOL CHEMICALS INC AL 8697 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AL 8697 is a selective p38(alpha) MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38(beta) (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity. purity: 99%
Medchemexpress LLC SCH772984 | 942183-80-4 | 99.8% | C33H33N9O2 | 200 MG
SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 nM for ERK1 and 1 nM for ERK2. It exhibits antitumor activity in both MAPK inhibitor-naive and MAPK inhibitor-resistant cells that contain BRAF or RAS mutations.
- Highly selective and ATP-competitive ERK inhibitor
- Exhibits antitumor activity in MAPK inhibitor-naive and resistant cells
- Induces G1 arrest and apoptosis in sensitive melanoma cells
- Inhibits ERK and RSK phosphorylation
- Shows EC50 values less than 500 nM in BRAF-mutant and RAS-mutant tumor lines
- Leads to significant tumor regression in animal models
- Well tolerated in vivo
Medchemexpress LLC Teniposide | 29767-20-2 | MFCD00866516 | 98.4% | 656.65 | 200 MG
Teniposide is a podophyllotoxin derivative that functions as a topoisomerase II inhibitor and is used as a chemotherapeutic agent.
- Acts as a topoisomerase II inhibitor
- Functions as a chemotherapeutic agent
- Demonstrates antiproliferative activity against various human cancer cell lines, including A549, CWR22R, HeLa, HepG2, MCF7, PC-3, and RPMI 8402
- Induces apoptosis in Tca8113 cells
- Causes cell cycle arrest at the G2/M phase in Tca8113 cells
- Can be formulated into a clear solution for in vivo experiments using various protocols, including 10% DMSO, 40% PEG300, 5% Tween-80, and 45% Saline, or 10% DMSO and 90% Corn Oil
- Referenced in multiple publications
Apexbio Technology LLC KN-92 176708-42-2 200mg
KN-92 is a structurally related but inactive analog of the CaMKII inhibitor KN-93 primarily utilized as a negative control compound in investigations of Ca2 /calmodulin-dependent kinase II (CaMKII) function Unlike KN-93 KN-92 does not effectively interfere with the binding of calmodulin (CaM) to the CaMKII enzyme and does not demonstrate substantial inhibition of CaMKII catalytic activity As a molecular control KN-92 allows researchers to distinguish between CaMKII-specific inhibitory effects and potential non-specific cellular influences when employing KN-93 in experimental models KN-93 itself selectively interacts with the CaM-binding region of CaMKII impeding enzyme activity implicated in cellular responses such as calcium-induced calcium release in cardiac cells histamine-stimulated aminopyrine uptake in gastric parietal cells and calcium-dependent induction of HIF-1 in cancer cells
Apexbio Technology LLC Mycophenolate Mofetil 128794-94-5 200mg
Mycophenolate Mofetil (128794-94-5) is a small-molecule inhibitor targeting inosine monophosphate dehydrogenase (IMPDH) isoforms I and II It is designed to selectively and reversibly inhibit IMPDH thereby disrupting de novo guanosine nucleotide biosynthesis Mycophenolate Mofetil exerts its biological activity primarily through non-competitive inhibition of IMPDH blocking the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) In in vitro studies Mycophenolate Mofetil demonstrates inhibitory activity with IC50 values of 39 nM and 27 nM for IMPDH I and II respectively Based on these pharmacological properties Mycophenolate Mofetil holds research potential in studies on immunology purine metabolism regulation cell proliferation transplant rejection and autoimmune disease models
Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 200mg, CAS: 519-02-8.
Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
![Medchemexpress LLC 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid | 368866-07-3 | MFCD02683117 | 99.4% | 466.53 | C26H30N2O6 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000301454.png-250.jpg)
Medchemexpress LLC 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid | 368866-07-3 | MFCD02683117 | 99.4% | 466.53 | C26H30N2O6 | 1 ML
SARS-CoV-2-IN-86 is a research-grade small molecule inhibitor of SARS-CoV-2 methyltransferases (nsp14 and nsp16), provided for in vitro biochemical and antiviral studies. It is available as solid material and as a 10 mM solution in DMSO, with documented purity and storage recommendations to support reproducible experimental use.
- High purity (99.35%) for reproducible results.
- Available as 10 mM solution in DMSO or as solid for flexible assay workflows.
- Well-characterized chemical identity (CAS 368866-07-3) and formula for traceability.
- Suitable for biochemical methyltransferase and antiviral research applications.
- Defined storage conditions to preserve stability in powder and solution formats.
- Datasheet available with specification and handling information.
![Medchemexpress LLC 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine | 1262618-39-2 | 99.6% | 347.22 | C14H7F6N3O | 200MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239161.png-250.jpg)
Medchemexpress LLC 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine | 1262618-39-2 | 99.6% | 347.22 | C14H7F6N3O | 200MG
GS967 (GS-458967) is a potent, selective inhibitor of the cardiac late sodium current (late INa) used as a research tool in preclinical electrophysiology and arrhythmia studies. It preferentially blocks persistent NaV1.5 currents and has reported IC50 values of 0.13 μM in ventricular myocytes and 0.21 μM in isolated hearts.
- Potent, selective late INa inhibition suitable for arrhythmia research.
- Reported IC50: 0.13 μM (ventricular myocytes), 0.21 μM (isolated hearts).
- High purity (approximately 99.6%), with certificate of analysis available.
- Molecular formula C14H7F6N3O; molecular weight 347.22 g/mol.
- Supplied as a powder; recommended storage -20°C for long-term storage, -80°C for solutions.
- Available in multiple package sizes to support assay development and in vivo studies.
Medchemexpress LLC KNK437 | 218924-25-5 | 99.0% | 245.23 g/mol | C13H11NO4 | 200 MG
KNK437 is a small-molecule heat shock protein (HSP) inhibitor that suppresses the induction of HSP105, HSP70, and HSP40. Provided as a light-yellow solid for research use, it is reported to have high purity and defined molecular weight, making it suitable for biochemical and cell-based studies of stress response and chaperone pathways.
- Inhibits induction of HSP105, HSP70, and HSP40.
- High purity suitable for biochemical and cell-based assays.
- Available in multiple pack sizes for experimental flexibility.
- Light-yellow solid form for standard laboratory handling.
- Stable when stored under recommended temperature conditions.
Apexbio Technology LLC LAQ824 (NVP-LAQ824,Dacinostat) 404951-53-7 200mg
LAQ824 (NVP-LAQ824 Dacinostat CAS 404951-53-7) is a synthetic derivative of 4-aminomethylcinnamic hydroxamic acid that functions as a histone deacetylase (HDAC) inhibitor It exhibits potent HDAC inhibition with an IC50 of 0 03 M LAQ824 has demonstrated the ability to inhibit proliferation across a range of human cancer cell lines including colorectal (H1299 HCT116) breast (MDA435 SKBR-3 BT-474 MB-468) prostate (DU145 PC3) and non-small cell lung (A549) cancer models with IC50 values below 1 M Additionally it induces apoptosis in breast cancer cells and suppresses multiple myeloma cell growth in a time- and dose-dependent manner LAQ824 is widely utilized in cancer research to study epigenetic regulation and evaluate HDAC inhibitor-based therapeutic strategies
Apexbio Technology LLC BMS-626529 701213-36-7 200mg
BMS-626529 is a small molecule inhibitor designed to block HIV-1 attachment to host cells Its mechanism involves binding to the viral envelope protein gp120 thereby hindering gp120-mediated interactions with CD4 receptors on CD4 T cells and preventing initial viral entry In cell-based assays BMS-626529 shows strain-specific antiviral activity with IC50 values mostly below 10 nM and notably low picomolar IC50 against highly susceptible HIV-1 isolates This molecule serves as a research tool to investigate HIV-1 entry inhibition and virus-host interaction mechanisms in biomedical studies
Apexbio Technology LLC Sotalol 3930-20-9 200mg
Sotalol (CAS 3930-20-9) is a non-selective adrenergic beta-receptor antagonist that inhibits both 1- and 2-adrenergic signaling pathways By blocking these receptors sotalol reduces sympathetic stimulation of the myocardium leading to decreased heart rate and myocardial contractility Furthermore it exhibits class III antiarrhythmic properties by prolonging cardiac action potential duration through inhibition of potassium channels Sotalol is utilized in biomedical research for investigating mechanisms underlying arrhythmogenesis and for evaluating therapeutic strategies in models of life-threatening ventricular and supraventricular arrhythmias
Medchemexpress LLC 2(1H)-Quinolinone, 8-hydroxy- | 15450-76-7 | MFCD00216696 | 99.89% | 161.16 | 500 G
8-Hydroxy-2(1H)-quinolinone is a biochemical reagent used in life science research. It is intended for research use only and not for medical applications.
- Can be used as a biological material or organic compound
- Suitable for life science related research
- Available in solid form
- White to off-white appearance