Thiophenes
Apexbio Technology LLC 4-Methylhistamine dihydrochloride 36376-47-3 1mg
4-Methylhistamine dihydrochloride (CAS 36376-47-3) is a selective agonist for the histamine H4 receptor (H4R) displaying a pEC50 of 7 4 0 1 at human H4R It exhibits over 100-fold selectivity for H4R relative to H3R and H2R and over 100 000-fold compared to H1R While affinity for human H4R is moderate it binds rat and mouse H4R with higher affinity (Ki values of 73 nM and 55 nM respectively) In in vivo models 4-Methylhistamine dihydrochloride modulates inflammatory signaling elevating TNF- and NF- B expression via JAK/STAT pathways in response to LPS-induced joint inflammation It serves as a valuable tool in studies of H4R-mediated immune regulation and inflammatory mechanisms
eMolecules 6165-68-0 | Thiophen-2-ylboronic acid | Ambeed | MFCD00151850 | 127.950 | C4H5BO2S | 98.000 | OB(O)c1cccs1 | 5g | 552669675
Thiophen-2-ylboronic acid | Ambeed | 6165-68-0 | MFCD00151850 | 127.950 | C4H5BO2S | 98.000 | OB(O)c1cccs1 | 5g | 552669675
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | 99.7% | 581.71 | 10 MG
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. It also has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Anticancer agent targeting mitochondrial tyrosine phosphatase, PTPMT1.
- Causes mitochondrial apoptosis.
- Antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Displays activity against most Candida spp., including fluconazole-resistant isolates.
- Complete inhibition of filamentation or proliferation of imaged fungi.
- Able to decimate mature biofilms of Candida, Cryptococcus, and Aspergillus spp. at low concentrations.
- Inhibits fungal biofilm growth and viability in a murine biofilm model.
Medchemexpress LLC Lomerizine dihydrochloride | 101477-54-7 | 99.95% | 50 MG
Lomerizine dihydrochloride is an antagonist of L- and T-type voltage-gated calcium channels. It also antagonizes transient receptor potential channel 5. Lomerizine is a dual L/T-type channel blocker that is used for prophylaxis of migraine.
- Antagonist of L- and T-type voltage-gated calcium channels.
- Demonstrates neuroprotective effects.
- Possesses activity in reversing multidrug resistance.
- Increases cerebral blood flow.
Medchemexpress LLC (E)-1,3-Di(thiophen-2-yl)prop-2-en-1-one | 42811-88-1 | 99.4% | 220.31 | 250 MG
(E)-1,3-Di(thiophen-2-yl)prop-2-en-1-one is a chemical compound primarily used as a drug intermediate for the synthesis of various active compounds. It is intended for laboratory research by experienced personnel in appropriately equipped and authorized facilities and has not been fully validated for medical applications.
- Used as a drug intermediate for synthesizing active compounds.
- Intended for laboratory research.
- Appears as a light yellow to yellow solid.
- Requires storage in a cool, well-ventilated area, away from direct sunlight and ignition sources.
- Store powder at -20°C for 3 years, or 4°C for 2 years.
- When in solvent, store at -80°C for 6 months, or -20°C for 1 month.
- Avoid breathing dust or vapors.
- Wear appropriate personal protective equipment during handling.
Medchemexpress LLC Zalunfiban dihydrochloride | 2815778-41-5 | 99.1% | 1 ML
Zalunfiban dihydrochloride is a potent, selective platelet αIIbβ3 antagonist (reported IC50 ≈ 45 nM) provided as the dihydrochloride salt for research applications, including studies of platelet aggregation and myocardial infarction.
- Potent αIIbβ3 antagonist with reported IC50 ≈ 45 nM.
- Provided as the dihydrochloride salt, soluble in DMSO.
- High purity (99.07%).
- Available as a 10 mM solution in 1 mL vials and in multiple solid sizes.
- Intended for preclinical and biochemical research use.
Cayman Chemical ThIophen-2-amIdoxIme 1g
A synthetic intermediate useful for pharmaceutical synthesis
Aobchem 2-Chloro-4-fluoro-3-(methylthio)pyridine | 97% | CAS 1935995-08-6 | C6H5ClFNS | 500mg
2-Chloro-4-fluoro-3-(methylthio)pyridine | 97% | CAS 1935995-08-6 | C6H5ClFNS | 500mg
Medchemexpress LLC SB 242084 dihydrochloride | 1049747-87-6 | MFCD02684417 | 98.1% | C21H21Cl3N4O2 | 10MG
SB 242084 dihydrochloride is a selective, high-affinity 5-HT2C receptor antagonist used in neuroscience research. It crosses the blood-brain barrier and is used to study serotonergic regulation of dopaminergic neurons, behavioral effects, and metabolic changes. Provided as a dihydrochloride salt and available in solution formats, it is intended for research use only.
- Selective 5-HT2C receptor antagonist
- High affinity (pKi = 9.0)
- Crosses the blood-brain barrier
- Suitable for in vitro and in vivo studies
- Available as solid salt and DMSO solution formats
- Intended for research use only
Apexbio Technology LLC Quinacrine 2HCl 69-05-6 10mM (in 1mL H2O)
Quinacrine 2HCl (69-05-6) is an orally active small-molecule inhibitor targeting the NF- B signaling pathway It is designed to inhibit the NF- B cascade thereby downregulating pro-survival gene expression and promoting apoptotic pathways in tumor cells Quinacrine 2HCl exerts its biological activity primarily through inhibition of NF- B and activation of the p53-dependent apoptotic pathway In in vitro studies Quinacrine 2HCl demonstrates growth inhibition of multiple cancer cell lines with reported IC50 values generally in the low micromolar range depending on the specific cell model and experimental context Based on these pharmacological properties Quinacrine 2HCl holds research potential in investigating apoptosis regulatory mechanisms NF- B pathway involvement in cancer biology and preclinical evaluation of potential anticancer therapies
Apexbio Technology LLC Cyclizine 2HCl 5897-18-7 50mg
Cyclizine 2HCl (CAS 5897-18-7) is a synthetic piperazine derivative that functions as an antagonist at histamine H1 receptors By inhibiting H1 receptor-mediated signaling Cyclizine 2HCl effectively suppresses histamine-induced physiological responses including those involved in allergic reactions and motion sickness This compound is widely utilized in biomedical research to investigate histaminergic pathways allergic mechanisms and the pharmacological modulation of H1 receptor activity Its antagonist properties make it valuable for studies examining the mechanistic basis of histamine-mediated processes and for evaluating novel anti-allergic therapeutics
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | 99.7% | 581.71 g/mol | C26H58Cl2N10 | 5 MG
Alexidine dihydrochloride is a bis-biguanide dihydrochloride salt used in biochemical and microbiological research as a mitochondrial tyrosine phosphatase (PTPMT1) inhibitor and as an antifungal/antibiofilm agent. It is supplied as a solid with high purity and is suitable for in vitro studies and for preparation of in vivo dosing formulations.
- Antifungal and antibiofilm activity demonstrated in diverse fungal pathogens.
- Targets mitochondrial tyrosine phosphatase PTPMT1 and can induce mitochondrial apoptosis.
- High purity (99.68%).
- Soluble in DMSO (125 mg/mL) and compatible with several in vivo formulation protocols.
- Stable when stored sealed at -20°C; solvent stability at -80°C for extended periods.
- Molecular weight 581.71 g/mol; molecular formula C26H58Cl2N10.
Medchemexpress LLC Ro 10-5824 dihydrochloride | 189744-94-3 | 99.9% | 353.29 g/mol | C17H22Cl2N4 | 25 MG
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist used in pharmacology and neuroscience research. It binds D4 receptors with high affinity and is supplied as a white to off-white solid for laboratory use.
- High purity (99.9%) for research applications.
- Selective D4 receptor partial agonist with Ki ≈ 5.2 nM.
- Molecular formula C17H22Cl2N4 and molecular weight 353.29 g/mol.
- Available in small milligram quantities for experimental studies.
- White to off-white solid suitable for handling and formulation.
eMolecules 104680-25-3 | Diethyl 2-aminothiophene-3,4-dicarboxylate | MFCD08059079 | 1g
Ambeed | [124]Triazolo[43-a]pyridin-6-amine | 100mg | 490491955 | A107576 | 1082448-58-5 | MFCD11597277 | 134.142 | C6H6N4
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![Medchemexpress LLC N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methylpiperazin-1-yl)benzamide dihydrochloride | 1831167-98-6 | 99.3% | 423.38 g·mol⁻¹ | C21H28Cl2N4O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294766.png-250.jpg)
Medchemexpress LLC N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methylpiperazin-1-yl)benzamide dihydrochloride | 1831167-98-6 | 99.3% | 423.38 g·mol⁻¹ | C21H28Cl2N4O | 10 MG
DDP-38003 dihydrochloride is a small-molecule, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with a reported IC50 of 84 nM. Supplied as the dihydrochloride salt, the compound is provided with a characterized molecular formula and high purity for research use.
- Orally available inhibitor of KDM1A/LSD1 with IC50 ≈84 nM.
- Supplied as a dihydrochloride salt to improve handling and solubility.
- High purity suitable for in vitro and in vivo research applications.
- Well-characterized molecular weight and formula for experimental planning.
- Available in multiple small-scale sizes to support laboratory workflows.