Thiophenes
Selleck Chemical LLC 1400W 2HCl
1400W (N-(3-(Aminomethyl)benzyl)acetamidine) is a slow tight binding and highly selective inhibitor of inducible nitric-oxide synthase(iNOS)
Apexbio Technology LLC Pramipexole dihydrochloride 104632-25-9 20mg
Pramipexole dihydrochloride is a small-molecule agonist targeting dopamine receptors exhibiting selective affinity toward the D3 dopamine receptor subtype and lower affinity for the D2L D2S and D4 subtypes It is designed to stimulate dopamine receptor-mediated signaling thereby modulating dopaminergic pathways involved in motor function Pramipexole dihydrochloride exerts its biological activity primarily through dopamine receptor agonism and also demonstrates receptor-independent neuroprotective effects by attenuating mitochondrial reactive oxygen species (ROS) production and decreasing apoptosis-related signaling cascades Based on these pharmacological properties pramipexole dihydrochloride holds research potential in exploring dopaminergic system involvement and neuroprotective mechanisms relevant to neurodegenerative conditions such as Parkinson s disease and restless legs syndrome
Apexbio Technology LLC 4-Methylhistamine dihydrochloride 36376-47-3 5mg
4-Methylhistamine dihydrochloride (CAS 36376-47-3) is a selective agonist for the histamine H4 receptor (H4R) displaying a pEC50 of 7 4 0 1 at human H4R It exhibits over 100-fold selectivity for H4R relative to H3R and H2R and over 100 000-fold compared to H1R While affinity for human H4R is moderate it binds rat and mouse H4R with higher affinity (Ki values of 73 nM and 55 nM respectively) In in vivo models 4-Methylhistamine dihydrochloride modulates inflammatory signaling elevating TNF- and NF- B expression via JAK/STAT pathways in response to LPS-induced joint inflammation It serves as a valuable tool in studies of H4R-mediated immune regulation and inflammatory mechanisms
Apexbio Technology LLC Ranolazine 2HCl 95635-56-6 10mM (in 1mL DMSO)
Ranolazine 2HCl (CAS 95635-56-6) is a small molecule frequently utilized in cardiovascular research for its antianginal and antiarrhythmic activities It modulates cardiac metabolism by partially inhibiting fatty acid -oxidation thereby increasing reliance on glucose oxidation This metabolic shift is mediated through activation of pyruvate dehydrogenase in ischemic myocytes enhancing glucose utilization during myocardial ischemia Ranolazine 2HCl s ability to alter substrate preference and improve cellular energetics under hypoxic conditions supports its application in studies of cardiac ischemia arrhythmias and myocardial metabolism
Medchemexpress LLC Acetyl-CoA Carboxylase-IN-1 | 179343-23-8 | C13H9Br2N5 | 50 MG
Acetyl-CoA Carboxylase-IN-1 is a potent inhibitor of acetyl-CoA carboxylase (ACC), demonstrating an IC50 value of less than 5 nM. This compound also exhibits significant antibacterial activity, with in vitro studies on *E. coli* showing minimum inhibitory concentration (MIC) values ranging from 0.1 μM to over 25 μM depending on the bacterial strain.
- Potent acetyl-CoA carboxylase (ACC) inhibitor
- Exhibits antibacterial activity against *E. coli*
- High purity of 99.18%
- Available as an off-white to light yellow solid
- Long-term stability as a powder at -20°C for up to 3 years
- Stable in solvent at -80°C for 6 months
Medchemexpress LLC Ro 10-5824 dihydrochloride | 189744-94-3 | 99.9% | 353.29 | C17H22Cl2N4 | 1 ML
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist supplied for research use. It is offered as a ready-to-use 10 mM solution in DMSO (1 mL) or as a solid, and is characterized for potency, purity, and identity for receptor pharmacology and in vitro studies.
- Selective dopamine D4 receptor partial agonist with reported Ki = 5.2 nM.
- Provided as a 10 mM solution in DMSO (1 mL) or as solid quantities for custom dosing.
- High purity (reported 99.86%), suitable for analytical and biological assays.
- Molecular weight 353.29, chemical formula C17H22Cl2N4, CAS 189744-94-3.
- Characterized with supporting documentation including datasheet, COA, LCMS, and SDS.
- Intended for receptor pharmacology, signaling studies, and in vitro assay applications.
Medchemexpress LLC Bisantrene dihydrochloride | 71439-68-4 | MFCD01743164 | 98.9% | 471.39 g/mol | C22H24Cl2N8 | 10 MG
Bisantrene dihydrochloride is the dihydrochloride salt of an anthracene-derived antitumor compound supplied as a solid for research use. It intercalates DNA and inhibits eukaryotic type II topoisomerases, making it useful in cytotoxicity, mechanism-of-action, and drug resistance studies.
Selleck Chemical LLC Methyl 3-aminopropanoate HCl
-Alanine ethyl ester is the ethyl ester of the non-essential amino acid -alanine
Apexbio Technology LLC Cyclizine 2HCl 5897-18-7 50mg
Cyclizine 2HCl (CAS 5897-18-7) is a synthetic piperazine derivative that functions as an antagonist at histamine H1 receptors By inhibiting H1 receptor-mediated signaling Cyclizine 2HCl effectively suppresses histamine-induced physiological responses including those involved in allergic reactions and motion sickness This compound is widely utilized in biomedical research to investigate histaminergic pathways allergic mechanisms and the pharmacological modulation of H1 receptor activity Its antagonist properties make it valuable for studies examining the mechanistic basis of histamine-mediated processes and for evaluating novel anti-allergic therapeutics
Medchemexpress LLC Ro 10-5824 dihydrochloride | 189744-94-3 | 99.9% | 353.29 g/mol | C17H22Cl2N4 | 100 MG
Ro 10-5824 dihydrochloride is a selective partial agonist at the dopamine D4 receptor (Ki = 5.2 nM). Supplied as the dihydrochloride salt in solid form for research use, it is used in receptor pharmacology, GPCR functional assays, and screening applications requiring selective D4 modulation. Chemical identity: C17H22Cl2N4 (CAS 189744-94-3).
- Selective partial agonist at dopamine D4 receptor (Ki = 5.2 nM).
- High reported purity (99.86%).
- Solid form for convenient handling and formulation.
- Stable when stored sealed and away from moisture; follow recommended temperature storage.
- Suitable for receptor pharmacology, GPCR assays, and screening workflows.
- Characterized by CAS number and molecular weight for traceability.
Medchemexpress LLC Ro 10-5824 dihydrochloride | 189744-94-3 | 99.9% | 353.29 g/mol | C17H22Cl2N4 | 25 MG
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist used in pharmacology and neuroscience research. It binds D4 receptors with high affinity and is supplied as a white to off-white solid for laboratory use.
- High purity (99.9%) for research applications.
- Selective D4 receptor partial agonist with Ki ≈ 5.2 nM.
- Molecular formula C17H22Cl2N4 and molecular weight 353.29 g/mol.
- Available in small milligram quantities for experimental studies.
- White to off-white solid suitable for handling and formulation.