Thiophenes
Medchemexpress LLC Acetyl-CoA Carboxylase-IN-1 | 179343-23-8 | C13H9Br2N5 | 5 MG
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. It also demonstrates antibacterial activity.
- Potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of <5 nM.
- Exhibits antibacterial activity.
- Purity: 99.18%.
Medchemexpress LLC Chroman 1 dihydrochloride | 1273579-40-0 | C24H30Cl2N4O4 | 25 MG
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor, demonstrating greater potency against ROCK2 (IC50=1 pM) compared to ROCK1 (IC50=52 pM). It also exhibits inhibitory activity against MRCK (IC50=150 nM) and has been shown to inhibit caspase-3/7 activation and reduce apoptosis in human pluripotent stem cells.
- Highly potent and selective ROCK inhibitor
- More potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM)
- Exhibits inhibitory activity against MRCK (IC50=150 nM)
- Inhibits caspase-3/7 activation
- Reduces apoptosis in human pluripotent stem cells
Apexbio Technology LLC Canertinib dihydrochloride 289499-45-2 100mg
Canertinib dihydrochloride (CAS 289499-45-2) is a small-molecule inhibitor targeting the pan-ErbB family of receptor tyrosine kinases It is designed to irreversibly inhibit ErbB receptors thereby disrupting Akt and MAPK signaling pathways Canertinib dihydrochloride exerts its biological activity primarily through irreversible binding to ErbB receptor family members In cell-based studies Canertinib dihydrochloride demonstrates apoptotic induction and reduced cell viability with an IC50 value of 3 5 nM Apoptosis induction was observed in BT474 (ErbB2-overexpressing breast cancer) and SK-N-SH (neuroblastoma) cell lines Based on these pharmacological properties Canertinib dihydrochloride holds research potential in oncology specifically for investigating ErbB signaling pathways and evaluating anti-tumor effects in cancer models
Apexbio Technology LLC Pramipexole 2HCl Monohydrate 191217-81-9 50mg
Pramipexole 2HCl Monohydrate is a synthetic non-ergoline dopamine receptor agonist targeting dopamine receptor subtypes particularly D3 D2S D2L and D4 It is designed to activate these receptors thereby modulating dopaminergic transmission pathways Pramipexole 2HCl Monohydrate exerts its biological activity primarily through selective receptor activation Based on these pharmacological properties Pramipexole 2HCl Monohydrate holds research potential in studies of receptor-ligand interactions receptor subtype functional analysis and dopamine-related neurologic or psychiatric disorders including Parkinson s disease and restless legs syndrome
Apexbio Technology LLC Ranolazine 2HCl 95635-56-6 10mg
Ranolazine 2HCl (CAS 95635-56-6) is a small molecule frequently utilized in cardiovascular research for its antianginal and antiarrhythmic activities It modulates cardiac metabolism by partially inhibiting fatty acid -oxidation thereby increasing reliance on glucose oxidation This metabolic shift is mediated through activation of pyruvate dehydrogenase in ischemic myocytes enhancing glucose utilization during myocardial ischemia Ranolazine 2HCl s ability to alter substrate preference and improve cellular energetics under hypoxic conditions supports its application in studies of cardiac ischemia arrhythmias and myocardial metabolism
Medchemexpress LLC Lubeluzole dihydrochloride | 144665-09-8 | 99.0% | 506.44 | C22H27Cl2F2N3O2S | 1 MG
Lubeluzole dihydrochloride is the dihydrochloride salt of lubeluzole, a neuroprotective research reagent that modulates neuronal voltage-gated sodium and calcium channels. It is provided as a high-purity solid intended for in vitro and preclinical pharmacology studies.
- 99.0% HPLC purity.
- White to off-white solid appearance.
- Molecular weight 506.44 g/mol.
- Molecular formula C22H27Cl2F2N3O2S.
- Storage: -20°C (sealed); in solution store at -80°C for long-term.
- Suitable for neuroscience and pharmacology research applications.
Apexbio Technology LLC NVP-BSK805 2HCl 1092499-93-8 (free base) 50mg
NVP-BSK805 2HCl is a selective ATP-competitive inhibitor targeting Janus kinase 2 (JAK2) JAK2 part of the JAK kinase family mediates signaling through cytokine receptor systems including type II cytokine GM-CSF receptor gp130 and single-chain receptor families By competitively binding the ATP-binding site of JAK2 NVP-BSK805 inhibits downstream STAT5 phosphorylation and JAK-mediated signaling It displays greater than 20-fold selectivity for JAK2 versus other JAK family members (JAK1 JAK3 TYK2) Cell-based assays demonstrate antiproliferative activity against cells expressing JAK2V617F mutations NVP-BSK805 is commonly employed in vitro and in vivo to investigate JAK2-mediated cellular responses oncogenesis and associated signaling pathways
eMolecules 126-33-0 | THIOPHENE, TETRAHYDRO-, 1,1-DIOXIDE | AstaTech | MFCD00005484 | 120.170 | C4H8O2S | 95.000 | O=S1(=O)CCCC1 | 100g | 718057691
THIOPHENE, TETRAHYDRO-, 1,1-DIOXIDE | AstaTech | 126-33-0 | MFCD00005484 | 120.170 | C4H8O2S | 95.000 | O=S1(=O)CCCC1 | 100g | 718057691
Medchemexpress LLC Thiophene-2 | 5MG
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 M and has potent anti-tuberculosis activity[1]
Apexbio Technology LLC H 89 2HCl 130964-39-5 50mg
H 89 2HCl (CAS 130964-39-5) is a small-molecule inhibitor targeting cyclic AMP-dependent protein kinase (PKA) It exhibits a Ki of approximately 48 nM toward PKA and demonstrates substantial selectivity compared to related kinases such as PKG (about 10-fold) PKC MLCK calmodulin kinase II and casein kinases (approximately 500-fold) In PC12D cells H 89 at micromolar concentrations suppresses forskolin-induced phosphorylation events and neurite outgrowth without altering intracellular cAMP levels Due to its selective inhibitory profile H 89 is widely utilized in cell signaling studies examining cAMP-dependent pathways
Medchemexpress LLC Methyl 3-oxohexanoate | 30414-54-1 | 144.17 | 10 G
Methyl 3-oxohexanoate (Methyl Butyrylacetate) is an organic compound commonly used in the manufacture of fragrances, drugs, and other chemicals. It functions as a condensation, diazotization, and addition reagent, playing a catalytic role in various organic synthesis reactions and drug synthesis.
- Used in the food industry for products like juices, beer, and confectionery.
- Functions as a condensation reagent.
- Functions as a diazotization reagent.
- Functions as an addition reagent.
- Catalytic role in organic synthesis reactions.
- Useful in drug synthesis.
- Biochemical reagent for life science-related research.
Medchemexpress LLC Ym-244769 dihydrochloride | 1780390-65-9 | 516.39 | 25 MG
Ym-244769 dihydrochloride is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50 values of 18 nM and 50 nM, respectively. This compound efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. It can also increase urine volume and urinary excretion of electrolytes in mice.
- Potent and selective Na+/Ca2+ exchanger (NCX) inhibitor.
- Preferentially inhibits NCX3.
- Suppresses unidirectional outward NCX current (Ca2+ entry mode).
- Protects against hypoxia/reoxygenation-induced neuronal cell damage.
- Increases urine volume and urinary excretion of electrolytes.
Apexbio Technology LLC GSK-LSD1 2HCl 2102933-95-7 100mg
GSK-LSD1 2HCl (CAS 2102933-95-7) is a selective irreversible inhibitor of lysine-specific demethylase 1A (LSD1) a flavin-dependent histone demethylase that modulates mono- and dimethylated lysine residues and is implicated in processes such as oocyte growth and tissue-specific differentiation GSK-LSD1 2HCl inhibits LSD1 with an IC50 of 16 nM and exhibits over 1000-fold selectivity against related FAD-utilizing enzymes including LSD2 MAO-A and MAO-B In cancer cell lines it demonstrates EC50 values below 5 nM for both gene expression modulation and growth inhibition GSK-LSD1 2HCl serves as a valuable chemical probe in epigenetics and cancer research
Apexbio Technology LLC 4-Aminobenzamidine dihydrochloride 2498-50-2 5g
4-Aminobenzamidine dihydrochloride (CAS 2498-50-2) is a small molecule inhibitor predominantly targeting serine proteases By binding competitively to the active sites of these enzymes it impedes proteolytic activity thereby modulating protease-mediated biological processes This compound is widely utilized in biochemical and cell-based assays to investigate the roles of serine proteases in various physiological and pathological contexts Its application extends to research on diseases characterized by dysregulated protease activity including certain cancers and inflammatory disorders where it serves as a tool for drug development and mechanistic studies