Thiophenes
Selleck Chemical LLC GSK-LSD1 2HCl
GSK-LSD1 2HCl is an irreversible and selective LSD1 inhibitor with IC50 of 16 nM 1000 fold selective over other closely related FAD utilizing enzymes (i e LSD2 MAO-A MAO-B)
Medchemexpress LLC Zalunfiban dihydrochloride | 2815778-41-5 | 99.1% | 1 ML
Zalunfiban dihydrochloride is a potent, selective platelet αIIbβ3 antagonist (reported IC50 ≈ 45 nM) provided as the dihydrochloride salt for research applications, including studies of platelet aggregation and myocardial infarction.
- Potent αIIbβ3 antagonist with reported IC50 ≈ 45 nM.
- Provided as the dihydrochloride salt, soluble in DMSO.
- High purity (99.07%).
- Available as a 10 mM solution in 1 mL vials and in multiple solid sizes.
- Intended for preclinical and biochemical research use.
Cayman Chemical ThIophen-2-amIdoxIme 1g
A synthetic intermediate useful for pharmaceutical synthesis
Apexbio Technology LLC Quinacrine 2HCl 69-05-6 10mM (in 1mL H2O)
Quinacrine 2HCl (69-05-6) is an orally active small-molecule inhibitor targeting the NF- B signaling pathway It is designed to inhibit the NF- B cascade thereby downregulating pro-survival gene expression and promoting apoptotic pathways in tumor cells Quinacrine 2HCl exerts its biological activity primarily through inhibition of NF- B and activation of the p53-dependent apoptotic pathway In in vitro studies Quinacrine 2HCl demonstrates growth inhibition of multiple cancer cell lines with reported IC50 values generally in the low micromolar range depending on the specific cell model and experimental context Based on these pharmacological properties Quinacrine 2HCl holds research potential in investigating apoptosis regulatory mechanisms NF- B pathway involvement in cancer biology and preclinical evaluation of potential anticancer therapies
Apexbio Technology LLC Cyclizine 2HCl 5897-18-7 50mg
Cyclizine 2HCl (CAS 5897-18-7) is a synthetic piperazine derivative that functions as an antagonist at histamine H1 receptors By inhibiting H1 receptor-mediated signaling Cyclizine 2HCl effectively suppresses histamine-induced physiological responses including those involved in allergic reactions and motion sickness This compound is widely utilized in biomedical research to investigate histaminergic pathways allergic mechanisms and the pharmacological modulation of H1 receptor activity Its antagonist properties make it valuable for studies examining the mechanistic basis of histamine-mediated processes and for evaluating novel anti-allergic therapeutics
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | 99.7% | 581.71 g/mol | C26H58Cl2N10 | 5 MG
Alexidine dihydrochloride is a bis-biguanide dihydrochloride salt used in biochemical and microbiological research as a mitochondrial tyrosine phosphatase (PTPMT1) inhibitor and as an antifungal/antibiofilm agent. It is supplied as a solid with high purity and is suitable for in vitro studies and for preparation of in vivo dosing formulations.
- Antifungal and antibiofilm activity demonstrated in diverse fungal pathogens.
- Targets mitochondrial tyrosine phosphatase PTPMT1 and can induce mitochondrial apoptosis.
- High purity (99.68%).
- Soluble in DMSO (125 mg/mL) and compatible with several in vivo formulation protocols.
- Stable when stored sealed at -20°C; solvent stability at -80°C for extended periods.
- Molecular weight 581.71 g/mol; molecular formula C26H58Cl2N10.
Medchemexpress LLC Ro 10-5824 dihydrochloride | 189744-94-3 | 99.9% | 353.29 g/mol | C17H22Cl2N4 | 25 MG
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist used in pharmacology and neuroscience research. It binds D4 receptors with high affinity and is supplied as a white to off-white solid for laboratory use.
- High purity (99.9%) for research applications.
- Selective D4 receptor partial agonist with Ki ≈ 5.2 nM.
- Molecular formula C17H22Cl2N4 and molecular weight 353.29 g/mol.
- Available in small milligram quantities for experimental studies.
- White to off-white solid suitable for handling and formulation.
![Medchemexpress LLC N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methylpiperazin-1-yl)benzamide dihydrochloride | 1831167-98-6 | 99.3% | 423.38 g·mol⁻¹ | C21H28Cl2N4O | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000294766.png-250.jpg)
Medchemexpress LLC N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methylpiperazin-1-yl)benzamide dihydrochloride | 1831167-98-6 | 99.3% | 423.38 g·mol⁻¹ | C21H28Cl2N4O | 10 MG
DDP-38003 dihydrochloride is a small-molecule, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with a reported IC50 of 84 nM. Supplied as the dihydrochloride salt, the compound is provided with a characterized molecular formula and high purity for research use.
- Orally available inhibitor of KDM1A/LSD1 with IC50 ≈84 nM.
- Supplied as a dihydrochloride salt to improve handling and solubility.
- High purity suitable for in vitro and in vivo research applications.
- Well-characterized molecular weight and formula for experimental planning.
- Available in multiple small-scale sizes to support laboratory workflows.
Sigma Aldrich Fine Chemicals Biosciences Methyl 3-methylthiopropion1KG
Methyl 3-(methylthio)propionate is a sulfur-containing flavor compound found in pineapple muskmelon and strawberries.
![Medchemexpress LLC 2-[2-(4-methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine, dihydrochloride | 1216722-25-6 | MFCD11100187 | 99.6% | 327.21 g·mol⁻¹ | C14H16Cl2N4O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000240418.png-250.jpg)
Medchemexpress LLC 2-[2-(4-methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine, dihydrochloride | 1216722-25-6 | MFCD11100187 | 99.6% | 327.21 g·mol⁻¹ | C14H16Cl2N4O | 5 MG
BYK 191023 dihydrochloride is a selective inducible nitric-oxide synthase (iNOS) inhibitor used in in vitro and in vivo research to probe iNOS-mediated pathways. It is supplied as a solid research chemical with high purity and is characterized by a defined molecular formula and molecular weight.
- Selective inhibitor of inducible nitric-oxide synthase for mechanistic studies
- High purity (≈99.6%) for reproducible results
- Well-characterized molecular weight 327.21 g·mol⁻¹ and chemical formula C14H16Cl2N4O
- Solid powder form for convenient handling and formulation
- Storage recommendations available for both solid and solution states
- Available in small research quantities suitable for assay development
eMolecules 2-aminothiophene-3-carboxylic acid | 56387-08-7 | MFCD03426102 | 1g
Pharmablock | 2-aminothiophene-3-carboxylic acid | 1g | 551228981 | PB95833 | | 56387-08-7 | MFCD03426102 | 143.160 | C5H5NO2S
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Medchemexpress LLC Prlx-93936 (dihydrochloride) | 1094210-96-4 | 10 MG
Research-grade HIF-1α inhibitor provided as the dihydrochloride salt for in vitro research. Reported to inhibit HIF-1α and the activated Ras pathway; intended for use in anticancer pathway studies and compound screening. Molecular formula C21H26Cl2N4O2; molecular weight 437.36; CAS 1094210-96-4.
- Dihydrochloride salt, suitable for laboratory research.
- Reported HIF-1α inhibitory activity and Ras pathway inhibition.
- Supplied in small mg package sizes for assay and screening use.
- Molecular formula C21H26Cl2N4O2; molecular weight 437.36.
- CAS number 1094210-96-4 for unambiguous identification.
Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 5mg
Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation
Medchemexpress LLC Rimcazole dihydrochloride | 75859-03-9 | 100.0% | 394.38 | 25 MG
Rimcazole dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. It also binds with moderate affinity to the dopamine transporter and inhibits dopamine uptake. It can reduce locomotor activity and sensitization and can be used for cancer research.
- Acts as a sigma (σ) receptor antagonist
- Binds to the dopamine transporter
- Inhibits dopamine uptake
- Reduces locomotor activity and sensitization
- Can be used for cancer research