Carboximidamides
Selleck Chemical LLC WM-3835-5mg
WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
Medchemexpress LLC 11R-VIVIT (cell permeable NFAT inhibitor) | 592517-80-1 | 99.6% | 3573.15 | 5 MG
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It is suitable for the research of podocyte and diabetic nephropathy.
- Significantly reduces NFAT2 expression in high glucose-treated podocytes
- Attenuates high glucose-induced filtration barrier dysfunction of podocytes
- Abrogates increased urinary albumin excretion rates
- Attenuates glomerular basement membrane (GBM) thickening and podocyte foot process effacement
- Partially restores podocyte number
- Inhibits NFAT2 activation and uPAR expression in glomerular podocytes
Medchemexpress LLC GDC-0276 50mg | 1494581-70-2 | 50 MG
Selective, orally active NaV1.7 inhibitor research compound intended for preclinical and clinical pharmacology studies. Demonstrates sub-nanomolar potency and favorable pharmacokinetics; supplied as a high-purity small-molecule solid for laboratory use.
- High purity (99.7%).
- Molecular weight 462.58.
- Chemical formula C24H31FN2O4S.
- Reported potency IC50 = 0.4 nM (NaV1.7).
- Supplied quantity 50 MG.
Medchemexpress LLC Creatine | 57-00-1 | 100.0% | 131.13 | 1 ML
Creatine is an endogenous amino acid derivative that plays a crucial role in cellular energy, particularly in muscle and brain function. It is involved in energy storage and transfer, supporting high-intensity, short-duration activities. This product is supplied as a 10 mM solution in 1 mL of water, prepared for reconstitution.
- Endogenous metabolite
- Involved in cellular energy production
- Supports muscle and brain function
- Supplied as a ready-for-reconstitution solution
Medchemexpress LLC 5'-Phosphoguanylyl-(3',5')-guanosine | 33008-99-0 | MFCD00064360 | 95.8% | 708.43 g/mol | C20H26N10O15P2 | 5 MG
5'-Phosphoguanylyl-(3',5')-guanosine (pGpG) is a nucleotide intermediate produced during enzymatic degradation of cyclic di-guanylate (c-di-GMP). It is supplied as a purified research reagent for biochemical and microbiology studies involving nucleotide signaling and enzymology.
- Purity 95.8% suitable for analytical and biochemical assays.
- Molecular weight 708.43 g/mol.
- Chemical formula C20H26N10O15P2.
- Available in milligram scales (5 mg, 10 mg, 25 mg, 50 mg, and larger sizes).
- Intended for biochemical assays and studies of nucleotide signaling and c-di-GMP metabolism.
- Provided with characterization data to support research use.
Medchemexpress LLC Guanidine-d5 hydrochloride | 108694-93-5 | MFCClD6N3 | 98% | 25 MG
Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) is a strong chaotrope and also a strong denaturant of proteins.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Nardosinone | 23720-80-1 | 250.33 | 5 MG
Nardosinone, isolated from Nardostachys chinensis, is identified as the first enhancer of the neuritogenic action of dbcAMP and staurosporine. It may serve as a pharmacological tool for studying the mechanism of action of nerve growth factor (NGF) and other neuritogenic substances.
- Purity of 99.81%
- Appearance as a white to off-white solid
- Store at 4°C, protected from light; in solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 100 mg/mL
- Initial source from plants, Valerianaceae, Nardostachys jatamansi (D. Don) DC.
- Classified as a terpenoid, sesquiterpene
- Exhibits antiinflammatory activity in RAW264.7 cells with an IC50 of 11.1 μM
Medchemexpress LLC (+)-Columbianetin | 3804-70-4 | 246.26 | 5 MG
(+)-Columbianetin is an active compound that functions as an inhibitor of JNK and ERK, and an activator of TGFβ signaling. It effectively mitigates UVA-induced cellular damage by reducing phosphorylation of JNK and ERK, decreasing MMP-1 production, and reversing collagen degradation. Additionally, it provides protection against UVB-induced harm to human keratinocytes.
- Inhibits JNK and ERK pathways.
- Activates TGFβ signaling.
- Reduces MMP-1 production.
- Reverses UVA-induced collagen degradation.
- Alleviates UVA-mediated inhibition of Smad2/3 phosphorylation.
- Regulates AP-1 and ASK1-MAPK signaling pathways.
- Inhibits ROS production.
- Protects human keratinocytes against UVB-induced damage.
- Applicable for research related to skin aging.
Medchemexpress LLC PIN1 inhibitor API-1 50mg | 680622-70-2 | 366.30 | C15H13F3N6O2 | 50 MG
PIN1 inhibitor API-1 is a selective peptidyl-prolyl cis-trans isomerase Pin1 inhibitor (IC50 = 72.3 nM) that binds the Pin1 PPIase domain and has been reported to up-regulate anticancer microRNA biogenesis and suppress hepatocellular carcinoma in preclinical models.
- Selective Pin1 inhibitor (IC50 72.3 nM).
- Molecular formula C15H13F3N6O2; molecular weight 366.30.
- Purity 99.63%.
- Appearance solid; color white to yellow.
- Soluble in DMSO (250 mg/mL); in vivo formulations ≥ 2.17 mg/mL in mixed solvents.
- Available in multiple package sizes including 50 MG.
Medchemexpress LLC Guanidine, N-methyl-, hydrochloride (1:1) | 21770-81-0 | 109.56 | 500 MG
1-Methylguanidine monohydrochloride is provided as a white to off-white solid. It has been tested and complies with the given specifications. This product is intended for research use only and has not been fully validated for medical applications.
- White to off-white solid appearance
- Tested and complies with specifications
- Storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
Medchemexpress LLC Clonidine hydrochloride | 4205-91-8 | MFCD00036705 | 99.9% | 500 MG
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent. It is intended for research use only.
- Agonist of α2-adrenoceptor
- Potent antihypertensive agent
- Induces CGRP mRNA expression
- Increases NO level in endothelial cells
- Decreases body temperature in rats
- Suppresses dopamine efflux in the prefrontal cortex