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Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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1

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | 50 MG
SDP

Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM, showing high selectivity for AChE over BuChE. It exhibits a neuroprotective effect on Aβ42 neurotoxicity. In vivo, Donepezil treatment prevents the progression of scopolamine-induced memory impairment in mice, demonstrating its potential in neurodegenerative research.

  • Reversible, selective AChE inhibitor
  • IC50 of 6.7 nM for AChE activity
  • High selectivity for AChE over BuChE
  • Exhibits a neuroprotective effect on Aβ42 neurotoxicity
  • Enhances phosphorylation of Akt and GSK-3β
  • Reduces phosphorylation of tau and glycogen synthase
  • Increases cell viability in cortical neuronal cells
  • Prevents scopolamine-induced memory impairment in mice

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.8% | C24H30ClNO3 | 1 G
SDP

Donepezil Hydrochloride (E2020) is a reversible, selective Acetylcholinesterase (AChE) inhibitor. It demonstrates high selectivity for AChE over Butyrylcholinesterase (BuChE) and exhibits neuroprotective effects against Aβ42 neurotoxicity. Its IC50 for AChE activity is 6.7 nM.

  • Reversible, selective AChE inhibitor
  • High selectivity for AChE over BuChE
  • Exhibits neuroprotective effects against Aβ42 neurotoxicity

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 25 MG
SDP

Donepezil Hydrochloride is a reversible, selective acetylcholinesterase (AChE) inhibitor with an IC50 of 6.7 nM. It demonstrates high selectivity for AChE over butyrylcholinesterase (BuChE) and offers neuroprotective effects against Aβ42 neurotoxicity. Its mechanism involves enhanced phosphorylation of Akt and GSK-3β, alongside reduced phosphorylation of tau and glycogen synthase.

  • Reversible, selective AChE inhibitor
  • High selectivity for AChE over BuChE
  • Neuroprotective effects on Aβ42 neurotoxicity
  • Enhances phosphorylation of Akt and GSK-3β
  • Reduces phosphorylation of tau and glycogen synthase
  • Prevents scopolamine-induced memory impairment in mice
  • Increases cell viability in cortical neuronal cells

ENCOMPASS_PREFERRED
4

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 100 MG
SDP

Donepezil Hydrochloride is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. It shows high selectivity for AChE over BuChE and exhibits a neuroprotective effect on Aβ42 neurotoxicity.

  • Reversible, selective AChE inhibitor
  • High selectivity for AChE over BuChE
  • Exhibits neuroprotective effect on Aβ42 neurotoxicity
  • For research use only.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Donepezil Hydrochloride | 120011-70-3 | 99.9% | C24H30ClNO3 | 500 MG
SDP

Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. It shows high selectivity for AChE over BuChE and exhibits a neuroprotective effect on Aβ42 neurotoxicity. Its neuroprotective mechanism is related to the enhanced phosphorylation of Akt and GSK-3β and reduced phosphorylation of tau and glycogen synthase.

  • Reversible, selective AChE inhibitor
  • Shows high selectivity for AChE over BuChE
  • Exhibits neuroprotective effect on Aβ42 neurotoxicity
  • Neuroprotective mechanism is related to enhanced phosphorylation of Akt and GSK-3β
  • Reduced phosphorylation of tau and glycogen synthase

ENCOMPASS_PREFERRED
6

Medchemexpress LLC 3-Acetyl-beta-boswellic acid | 5968-70-7 | 498.74 | 1 MG
SDP

3-Acetyl-beta-boswellic acid is a boswellic acid isolated from *Boswellia serrata* gum resin. It is for research use only and not sold to patients.

  • Purity: 98.10%
  • Appearance: Solid, white to off-white
  • Solubility: Soluble in DMSO (100 mg/mL)
  • Inhibits microsomal PGES1 in A549 cells with an IC50 of 3 μM
  • Shows cytotoxicity against human HL-60 cells with an IC50 of 10 μM after 48 hours
  • Shows cytotoxicity against human HeLa cells with an IC50 of 22 μM after 48 hours
  • Store at 4°C, sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month.

ENCOMPASS_PREFERRED
7

Medchemexpress LLC Methotrexate alpha-tert-butyl ester | 79640-70-3 | 95.1% | C24H30N8O5 | 10MG
SDP

Methotrexate α-tert-butyl ester is a tert-butyl ester derivative of methotrexate supplied for research use; it is characterized for biochemical and pharmacological studies and has known physical properties suitable for laboratory handling.

  • Tert-butyl ester derivative of methotrexate.
  • Molecular formula C24H30N8O5.
  • Molecular weight 510.55 g/mol.
  • Purity 95.1% (supplier listing).
  • Melting point >211 °C (decomposition).
  • Available in small research pack sizes (10 mg).

ENCOMPASS_PREFERRED
8

Medchemexpress LLC 3-Acetyl-beta-boswellic acid | 5968-70-7 | MFCD03788773 | 498.74 | 5 MG
SDP

3-Acetyl-beta-boswellic acid is a boswellic acid isolated from Boswellia serrata gum resin. It is a pentacyclic triterpenoid compound.

  • Inhibits microsomal PGES1 in A549 cells (IC50: 3 μM).
  • Cytotoxic against human HL60 cells (IC50: 10 μM) and HeLa cells (IC50: 22 μM).
  • Shows antiproliferation activity against HUVEC cells (> 100 μM).
  • Inhibits human recombinant COX2 expressed in baculovirus infected Sf21 cells (> 40 μM).

ENCOMPASS_PREFERRED
9

Medchemexpress LLC Methotrexate alpha-tert-butyl ester | 79640-70-3 | 96.0% | 510.55 g/mol | C24H30N8O5 | 5 MG
SDP

Methotrexate alpha-tert-butyl ester is a tert-butyl ester derivative of methotrexate supplied as a research-grade biochemical. It functions as an antimetabolite and antifolate and is intended for laboratory research use only, not for human therapeutic application.

  • Used in biochemical and cancer research applications.
  • Antimetabolite and antifolate activity.
  • Supplied as a small-scale research reagent, typical pack sizes include 5 mg.
  • Molecular formula C24H30N8O5; molecular weight 510.55 g/mol.
  • Purity typically reported around 96.0%.

ENCOMPASS_PREFERRED
10

eMolecules​ (1H-INDOL-2-YL)METHANOL | AstaTech | 24621-70-3 | MFCD00030195 | 147.177 | C9H9NO | 95.000 | OCc1cc2ccccc2[nH]1 | 25g | 449718949

(1H-INDOL-2-YL)METHANOL | AstaTech | 24621-70-3 | MFCD00030195 | 147.177 | C9H9NO | 95.000 | OCc1cc2ccccc2[nH]1 | 25g | 449718949

ENCOMPASS_PREFERRED
11

Ambeed 1H-INDOL-2-YLMETHANOL-25G

(1H-Indol-2-yl)methanol- 25gramsAmbeed CAS No.: 24621-70-3

ENCOMPASS_PREFERRED
12

Medchemexpress LLC SUVN-911 | 2414674-71-6 | 99.13% | 261.15 | 100 MG
SDP

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity.

  • Potent, selective, brain-penetrant, orally bioavailable α4β2 receptor antagonist (Ki: 1.5 nM).
  • Demonstrates antidepressant activity.
  • High selectivity for α4β2 over α3β4 nAChR.
  • Good selectivity against 70+ receptors (GPCRs, ion channels, enzymes, etc.).
  • Devoid of cardiovascular and gastrointestinal side effects.
  • Significant antidepressant effects in male Wistar rats (1-10 mg/kg, p.o., daily, 3 days).
  • Shows metabolic stability in rats.
  • High oral exposure, longer half-life, and adequate brain penetration in Wistar rats (3 mg/kg, p.o.).

ENCOMPASS_PREFERRED