Alcohols and polyols
Medchemexpress LLC (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide | 133550-41-1 | 99.9% | 336.39 g/mol | C20H20N2O3 | 10 MG
(E)-AG 556 is a research-grade small-molecule inhibitor of the epidermal growth factor receptor (EGFR). It is highly selective for EGFR kinase activity and has been reported to block lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production. The compound is supplied as a solid with high reported purity and is typically dissolved in DMSO for in vitro studies.
- Highly selective EGFR tyrosine kinase inhibitor.
- Reported to block LPS-induced TNF-α production.
- High purity (reported ~99.9%).
- Solid, light yellow to yellow appearance.
- Soluble in DMSO for preparation of stock solutions.
- Suitable for cell-based and biochemical assays.
Medchemexpress LLC ALK4290 (AKST4290) | 1251528-23-0 | 99.8% | 512.04 | 50 MG
ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor with a Ki of 3.2 nM for hCCR3. It can be used for the research of neovascular age-related macular degeneration and Parkinsonism.
- Potent and orally active CCR3 inhibitor
- Ki of 3.2 nM for hCCR3
- Suitable for research on neovascular age-related macular degeneration
- Suitable for research on Parkinsonism
- Has a purity of 99.79%
- Molecular weight is 512.04
- Appears as a solid, white to off-white substance
Medchemexpress LLC Emixustat hydrochloride | 1141934-97-5 | 99.29% | 299.84 | 5 MG
Emixustat hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. It is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD).
- Orally active RPE65 inhibitor
- IC50 value of 4.4 nM
- Visual cycle modulator
- Inhibits retinol isomerization
- Regulates visual cycle activity
- Investigated for potential in studying vision disorders such as age-related macular degeneration (AMD)
Medchemexpress LLC ALK4290 (AKST4290) | 1251528-23-0 | >99.8% | 512.04 | 100 MG
ALK4290 (AKST4290) is a potent and orally active CCR3 inhibitor, derived from patent US20130261153A1, compound Example 2, demonstrating a Ki of 3.2 nM for human CCR3. This compound is suitable for research related to neovascular age-related macular degeneration and Parkinsonism.
- Potent and orally active CCR3 inhibitor.
- Exhibits a Ki of 3.2 nM for hCCR3.
- Used in research for neovascular age-related macular degeneration.
- Used in research for Parkinsonism.
- Available in high purity (99.79%).
- Offered in both solid and solution forms for research use.
Apexbio Technology LLC Pregnenolone 145-13-1 5g
Pregnenolone (CAS 145-13-1) also known as 3 -hydroxypregn-5-en-20-one or P5 is an endogenous neurosteroid and precursor of nearly all other steroid hormones including DHEA testosterone progesterone estrogens and cortisol In the central nervous system pregnenolone modulates synaptic transmission and has been shown to influence learning and memory processes In rodent models its sulfate derivative (PREGS) improves age-related impairments in memory retention in a dose-dependent manner Clinical findings on its cognitive benefits are mixed with some studies reporting enhanced memory in individuals with low baseline PREGS levels Pregnenolone is widely used in neuroscience research on neurosteroid function and cognitive aging
Medchemexpress LLC Tert activator-1 | 666699-46-3 | MFCD00120536 | 99.5% | 331.77 g·mol⁻¹ | C14H12ClF2NO2S | 10 MG
TERT activator-1 is a small-molecule activator of telomerase reverse transcriptase used as a research reagent to study telomerase regulation, neurogenesis, and aging-related pathways. It modulates TERT transcription via the MEK/ERK/AP-1 cascade and is supplied with supporting analytical documentation for laboratory use.
- Promotes adult neurogenesis and enhances neuromuscular function.
- Reduces cellular senescence and systemic inflammation in aged models.
- Small-molecule mechanism targeting TERT transcriptional activation.
- High purity suitable for research applications.
- Available as powder and as a DMSO solution for convenience.
- Analytical documents available: COA, NMR, HPLC, LCMS, SDS.
Medchemexpress LLC Emixustat hydrochloride (ACU-4429 hydrochloride) | 1141934-97-5 | 99.3% | 299.84 | 1 ML
Emixustat hydrochloride (ACU-4429 hydrochloride) is an orally active RPE65 inhibitor. It functions as a visual cycle modulator, regulating visual cycle activity by inhibiting retinol isomerization, and shows potential for studying vision disorders, including age-related macular degeneration (AMD).
- Orally active RPE65 inhibitor
- Functions as a visual cycle modulator
- Regulates visual cycle activity by inhibiting retinol isomerization
- Potential for studying vision disorders such as age-related macular degeneration (AMD)
- Inhibits RPE65 activity with an IC50 of 4.4 nM
- Reduces 11-cis-retinol production
- Shown to inhibit neovascularization and protect the retina in an oxygen-induced retinopathy mouse model
Medchemexpress LLC Emixustat hydrochloride | 1141934-97-5 | 99.3% | 299.84 | 50 MG
Emixustat hydrochloride (ACU-4429) is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. It functions as a visual cycle modulator by inhibiting retinol isomerization. This compound shows potential for research into vision disorders such as age-related macular degeneration (AMD).
- Reduces the production of 11-cis-retinol in a concentration-dependent manner, thereby inhibiting RPE65 activity.
- Reduces the conductance of retinal cation channels after dark adaptation in rats.
- Dose-dependently reduces retinal neovascularization in an Oxygen-Induced Retinopathy (OIR) mouse model.
Medchemexpress LLC Carboxyatractyloside tripotassium | 77228-71-8 | 885.09 | 5 MG
Carboxyatractyloside tripotassium is a diterpenoid that can be isolated from plants of the genus Xanthium. It functions as an ADP/ATP carrier inhibitor, specifically inhibiting mitochondrial ADP/ATP transport. This compound promotes ROS production, induces Ca2+ release, and leads to mitochondrial dysfunction, and has been observed to induce lethargy, weakness, and epileptic seizures in rats.
- Promotes cell death in primary mouse lung endothelial cells.
- Exacerbates mitochondrial dysfunction, including depolarization, increased ROS generation, and MPT pore opening.
- Induces Ca2+ release, mitochondrial swelling, and membrane potential collapse in aged rat liver mitochondria.
- Causes histopathological damage to the liver and kidneys, including vacuolar degeneration and necrosis of hepatocytes and renal tubular necrosis.
Medchemexpress LLC HY-106353 10mg Medchemexpress, Smilagenin CAS:126-18-1 Purity:>98%
Medchemexpress, HY-106353 10mg Smilagenin CAS:126-18-1 Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density.Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-106353 5mg Medchemexpress, Smilagenin CAS:126-18-1 Purity:>98%
Medchemexpress, HY-106353 5mg Smilagenin CAS:126-18-1 Smilagenin (SMI) is a lipid-soluble small-molecule steroidal sapogenin from Rhizoma anemarrhenae and Radix asparagi widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases [1] . Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density [2] .Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD [3] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Alcohol oxidase | 9073-63-6 | 250 U
Alcohol oxidase is a functional enzyme involved in the methanol utilization pathway, isolated from yeast peroxisome. It oxidizes methanol to formaldehyde. One unit is defined as the amount of enzyme that can oxidize 1.0 μmole of methanol to formaldehyde per minute at pH 7.5 at 37°C.
- Appearance: solid
- Color: light yellow to yellow
- EC number: 1.1.3.13
- Enzyme activity: ≥5 U/mg solid
- Isoelectric point: 5.4-5.8
- pH range: 6.5-8.5, with an optimum pH of 7.5
- Cofactor: FAD, one molecule per subunit
- Solubility: ≥ 50 mg/mL in H2O
- Inhibitors include: H2O2, propynal, PCMB, iodoacetate, 1,4-butynediol, sodium acetate, cyclopropanone, 4-hydroxy-2-butynal, diethyl dicarbonate, Hg2+, Ag+, and Cu2+