Cinnamic acids and derivatives
Aobchem (1E 2E)-1 2-Bis(2 6-Diisopropylphenylimino)ethane | ≥95% | CAS 74663-75-5 | C26H36N2 | 1g
(1E 2E)-1 2-Bis(2 6-Diisopropylphenylimino)ethane | ≥95% | CAS 74663-75-5 | C26H36N2 | 1g
Aobchem (1E 2E)-1 2-Bis(2 6-Diisopropylphenylimino)ethane | ≥95% | CAS 74663-75-5 | C26H36N2 | 25g
(1E 2E)-1 2-Bis(2 6-Diisopropylphenylimino)ethane | ≥95% | CAS 74663-75-5 | C26H36N2 | 25g
Selleck Chemical LLC AMG-458 S2747-5mg
AMG 458 is a potent c-Met inhibitor with Ki of 1 2 nM 350-fold selectivity for c-Met than VEGFR2 in cells
Selleck Chemical LLC (R)-(-)-JQ1 Enantiomer S2965-25mg
(R)-(-)-JQ1 Enantiomer is the stereoisomer of ( )-JQ1 ( )-JQ1 potently decreases expression of both BRD4 target genes whereas (R)-(-)-JQ1 Enantiomer has no effect
![Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402443-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, showing at least 500-fold higher selectivity for ErbB2 over EGFR. This compound exhibits anticancer activity.
- Significantly decreases cell proliferation in various cell lines
- Induces a dose-dependent increase in apoptosis
- Reduces tumor sizes in animal models
Medchemexpress LLC (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | 100667-52-5 | 97.0% | 280.36 g/mol | C19H20O2 | 5 MG
(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one is a diarylheptanoid small-molecule for laboratory research and analytical applications. The compound is supplied as a solid with molecular formula C19H20O2, molecular weight 280.36 g/mol, and an analytical purity of 97.0% (NMR). Store protected from light at low temperatures; consult the certificate of analysis for batch-specific handling and stability information.
- Solid, white to off-white appearance.
- Molecular formula C19H20O2.
- Molecular weight 280.36 g/mol.
- Analytical purity 97.0% (NMR).
- Storage: keep container tightly sealed, protect from light; recommended -20°C for solid, in solvent -80°C for 6 months or -20°C for 1 month.
- Intended for research and analytical use only; not for human therapeutic use.
Medchemexpress LLC Tyrphostin 25 | 118409-58-8 | MFCD00133900 | 99.0% | 202.17 | C10H6N2O3 | 10 MG
Tyrphostin 25 (AG82) is a small-molecule research compound that selectively inhibits epidermal growth factor receptor (EGFR) tyrosine kinase and acts as a GPR35 agonist. It prevents EGFR autophosphorylation and reduces EGF-induced cell migration in vitro. Supplied as a yellow to brown solid with high analytical purity for laboratory research; for research use only.
- High purity: 99.0%.
- Molecular weight: 202.17 g/mol.
- Chemical formula: C10H6N2O3.
- Physical form: solid, yellow to brown powder.
- Biological activity: EGFR IC50 ≈ 3 μM (A431 cells); GPR35 EC50 ≈ 5.3 μM.
- Storage: powder -20°C (stable for years); in solution -80°C (months).
- SDS available in multiple languages.
- Intended use: for research use only.
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 100 MG
MRL-494 hydrochloride is an antibacterial agent that acts as an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, and lethally disrupts the cytoplasmic membrane. It inhibits outer membrane proteins (OMPs) biogenesis by targeting BamA, demonstrating strong anti-microbial properties against various bacteria.
- Acts as an inhibitor of β-barrel assembly machine A (BamA)
- Impervious to efflux and outer membrane permeability barrier
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
- Strong anti-microbial properties against Gram-positive bacteria (e.g., *Staphylococcus aureus* with MIC of 12.5 μM)
- Strong anti-microbial properties against Gram-negative bacteria (e.g., *E. coli* with MIC of 25 μM)
Medchemexpress LLC Entacapone (Standard) | 130929-57-6 | 99.2% | C14H15N3O5 | 50 MG
Entacapone (Standard) is the analytical standard of Entacapone. It is a potent, reversible, peripherally acting, and orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits COMT from rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. It is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M), and PST-P (IC50s>50 μM).
- Used for research of Parkinson's disease
- Serves as an inhibitor of FTO demethylation with an IC50 of 3.5 μM, for research of metabolic disorders
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Intended for research and analytical applications
TARGETMOL CHEMICALS INC TYRPHOSTIN AG1296 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 uM no activity to EGFR. purity: 99%
Selleck Chemical LLC Tyrphostin AG 1296
Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0 3-0 5 M no activity to EGFR Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12 3 M and 1 8 M in Swiss 3T3 cells Tyrphostin AG1296 induces dramatic apoptosis in A375R cells
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | C14H15N3O5 | 1 ML
Entacapone is a potent, reversible, peripherally acting, and orally active catechol-O-methyltransferase (COMT) inhibitor. It is selective for COMT over other catecholamine metabolizing enzymes. It inhibits COMT from rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone can be used for Parkinson's disease research and as an inhibitor of FTO demethylation with an IC50 of 3.5 μM, making it useful for research into metabolic disorders.
- Potent, reversible, peripherally acting, and orally active COMT inhibitor
- Selective for COMT over other catecholamine metabolizing enzymes
- Inhibits COMT from rat brain, erythrocytes, and liver
- Utilized in Parkinson's disease research
- Functions as an inhibitor of FTO demethylation
- Applied in metabolic disorders research
TARGETMOL CHEMICALS INC UMBRALISIB R-ENANTIOMER 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against (delta)PI3 kinase is at least 20 times lower than that of the inhibitors against other PI3K isoforms (A (beta) and (gamma)). purity: 95%
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
TARGETMOL CHEMICALS INC CIPROPRIDE S ENANTIOMER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Cipropride S enantiomer is the S enantiomer of cipropride which is an antiemetic drug. purity: 99%