Flavonoids
Sigma Aldrich Fine Chemicals Biosciences Naringin >=95% (HPLC) | 10236-47-2 | MFCD00148888 | 100G
Naringin >=95% (HPLC) | Purity: >=95% (HPLC) | Mol Wt: 580.53 | 10236-47-2 | MFCD00148888 | 100G
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 1 ML
AMG 487 (S-enantiomer) is the S enantiomer of AMG 487, a potent antagonist of the chemokine receptor CXCR3. This product is intended for research use only.
- Acts as an antagonist of the chemokine receptor CXCR3
- High purity (99.94%)
- S-enantiomer form
- Suitable for research applications
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 2 MG
AMG 487 (S-enantiomer) is the S enantiomer of AMG 487, functioning as an antagonist of the chemokine receptor CXCR3. It is intended for research use only.
- Antagonist of chemokine receptor
- Available in solid and solution forms
- High purity (99.94%)
- Off-white to light yellow appearance
- Stable for extended periods under proper storage conditions
Apexbio Technology LLC (±)-AMG 487 50mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C₃₂H₂₈F₃N₅O₄ | 50 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487 and functions as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with a purity of 99.94%.
- Functions as an antagonist of the chemokine receptor CXCR3
- High purity of 99.94%
- Supplied as a solid
- Soluble in DMSO
Medchemexpress LLC AST 487 | 630124-46-8 | 98.9% | 529.56 | 25 MG
AST 487 is a potent RET kinase inhibitor with an IC50 of 880 nM, and also demonstrates inhibitory activity against Flt-3 with an IC50 of 520 nM. It effectively inhibits RET autophosphorylation and the activation of downstream effectors, making it suitable for studies on human thyroid cancer cell lines with activating RET mutations.
- Inhibits RET kinase (IC50 880 nM)
- Inhibits Flt-3 (IC50 520 nM)
- Targets other kinases including KDR, Flt-4, c-Kit, and c-Abl
- Potently inhibits growth of human thyroid cancer cell lines with activating RET mutations
- Functions as a novel, mutant FLT3 inhibitor
- Inhibits cellular proliferation in FLT3-ITD-Ba/F3 and D835Y-Ba/F3 cells (IC50 less than 5 nM)
Medchemexpress LLC Flavanone | 487-26-3 | 1 ML
Flavanone is a naturally occurring flavone with inhibitory activity for human estrogen synthetase (aromatase) and acts as an inhibitor for the ERK/p38/NF-κB signaling pathway. It exhibits oral activity and antitumor efficacy, demonstrating its potential in various biological processes.
- Inhibits cell proliferation, migration, and invasion of A549 cells
- Arrests cell cycle at G1 phase in vitro
- Inhibits expression of MMP-2, u-PA, cyclin D1, and CDK2
- Promotes generation of TIMP-2 and PAI-1
- Exhibits antitumor efficacy in C57BL/6J mouse models
- Limits tumor growth and inhibits metastasis of LLC cells in vivo
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 g/mol | C15H12O3 | 1 G
3'-Hydroxyflavanone is a cyclized flavanone (C15H12O3) reported to induce apoptosis in HeLa cells and to possess antitumor activity in cellular studies. It is employed in biochemical and pharmacological research to probe apoptosis pathways and to study flavonoid bioactivity.
- Cyclized flavanone scaffold with a 3'-hydroxy substitution.
- Reported to induce apoptosis in HeLa cells.
- Demonstrated antitumor activity in preclinical cellular studies.
- Useful as a biochemical probe for apoptosis-related pathways.
- Supplied as a solid with defined molecular formula and molecular weight.
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | MFCD00006734 | 5 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone and has potential for hepatic steatosis and dyslipidemia research.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 | C15H12O3 | 100 MG
3′-Hydroxyflavanone is a cyclized flavanone research compound reported to induce apoptosis in HeLa cells and to possess antitumor activity. It is intended for in vitro biochemical and cellular studies and is supplied with an accompanying datasheet for characterization and safety information.
- Cyclized flavanone structure suitable for flavonoid research.
- Reported to induce apoptosis in HeLa cells.
- Reported antitumor activity in literature.
- Available in multiple pack sizes from milligram to gram quantities.
- Supplied in high-purity grades with supporting datasheet.
Medchemexpress LLC AMG 487 (S-enantiomer) | 473720-30-8 | C32H28F3N5O4 | 100 MG
AMG 487 S-enantiomer is the S enantiomer of AMG 487, which acts as an antagonist of the chemokine receptor CXCR3. This chemical compound is provided as an off-white to light yellow solid with high purity.
- High purity: 99.94%
- Antagonist of chemokine receptor CXCR3
- Stable as powder at -20°C for 3 years, and 4°C for 2 years
- Stable in solvent at -80°C for 2 years, and -20°C for 1 year
- Soluble in DMSO at 100 mg/mL
TARGETMOL CHEMICALS INC PINOCEMBRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pinocembrin (57-Dihydroxyflavanone) is a flavanone a type of flavonoid. It is an antioxidant found in damiana honey fingerroot and propolis. purity: 98%