Flavonoids
TARGETMOL CHEMICALS INC PHILLYRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Phillyrin (Forsythin) is a novel AMPK activator has anti-obesity effects in nutritive obesity mice it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting it potentially contributes to the suppression of the activation of MAPK and NF-(kappa)B pathways it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells. purity: 99%
TARGETMOL CHEMICALS INC AST 487 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AST 487 (NVP-AST 487) is a RET kinase inhibitor inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3. purity: 99%
Apexbio Technology LLC AMG 487 473719-41-4 100mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
![Medchemexpress LLC 5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one | 1399049-81-0 | 98.0% | 408.53 g/mol | C26H32O4 | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238691.png-250.jpg)
Medchemexpress LLC 5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one | 1399049-81-0 | 98.0% | 408.53 g/mol | C26H32O4 | 25MG
PSB-SB-487 is a small-molecule research compound that functions as a potent GPR55 antagonist and a CB2 receptor agonist. It is used in preclinical pharmacology studies to investigate metabolic disorders, neurodegenerative conditions, neuropathic pain, and cancer. The compound is supplied at high purity and is characterized by CAS 1399049-81-0 and molecular formula C26H32O4.
- Potent GPR55 antagonist (IC50 0.113 μM).
- CB2 receptor agonist (Ki 0.292 μM for human CB2).
- High purity suitable for preclinical research.
- Defined molecular formula and molecular weight (C26H32O4, 408.53 g/mol).
- Available in multiple package sizes for experimental flexibility.
![Medchemexpress LLC N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (AST 487) | 630124-46-8 | MFCD11983171 | 98.9% | 529.56 g/mol | C26H30F3N7O2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286670.png-250.jpg)
Medchemexpress LLC N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea (AST 487) | 630124-46-8 | MFCD11983171 | 98.9% | 529.56 g/mol | C26H30F3N7O2 | 10 MG
AST-487 is a small-molecule RET kinase inhibitor provided for laboratory research. It inhibits RET autophosphorylation and downstream signaling (reported RET IC50 ≈ 880 nM) and shows activity against FLT3 (IC50 ≈ 520 nM) and several other kinases. The compound is supplied as a solid and as a DMSO solution and is intended for research use only.
- Inhibits RET kinase with reported IC50 ≈ 880 nM.
- Shows activity against FLT3 with reported IC50 ≈ 520 nM.
- Chemical formula C26H30F3N7O2; molecular weight ≈ 529.6 g/mol.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High supplier-reported purity (98.9% by supplier specification).
- Intended for research use only; not for clinical or human therapeutic use.
eMolecules 35244-11-2 | 2'-Hydroxyflavone | MFCD00017673 | 1g
ChemScene | tert-Butyl 4-[(2-amino-13-thiazol-4-yl)methyl]piperazine-1-carboxylate | 100mg | 788447031 | CS-0070856 | 856418-80-9 | MFCD15147067 | 298.410 | C13H22N4O2S
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Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 50 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone, with potential for hepatic steatosis and dyslipidemia research.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
![Medchemexpress LLC 5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one | 1399049-81-0 | 98.0% | 408.53 | C26H32O4 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238635.png-250.jpg)
Medchemexpress LLC 5-hydroxy-3-[(2-hydroxyphenyl)methyl]-7-(2-methylnonan-2-yl)chromen-2-one | 1399049-81-0 | 98.0% | 408.53 | C26H32O4 | 10MG
PSB-SB-487 is a coumarin-derived research compound that acts as a potent GPR55 antagonist and CB2 receptor agonist, used in preclinical studies of metabolic disorders, neurodegeneration, neuropathic pain, and cancer. It is supplied for laboratory research in multiple small-mass quantities and includes chemical identifiers and structural data for experimental reproducibility.
- Potent GPR55 antagonist and CB2 agonist.
- Molecular formula C26H32O4 and molecular weight 408.53.
- High purity (98.0%) suitable for research applications.
- Available in small-mass sizes for laboratory experiments.
- Relevant for studies of metabolic disorders, neurodegeneration, pain, and cancer.
- Provided with CAS number and structural identifiers for traceability.
Selleck Chemical LLC AMG 487
AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8 0 nM and 8 2 nM respectively
Indofine Chemical GENISTEIN, Flavonoid & Coumarins, 446-72-0, 98+%, 100 mg
GENISTEIN, Flavonoid & Coumarins, 446-72-0, 98+%, 100 mg
Selleck Chemical LLC Farrerol-5mg
Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects.
TARGETMOL CHEMICALS INC AMG 487 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. Purity 99.89%
Selleck Chemical LLC AST-487
AST-487 (NVP-AST487) a N N -diphenyl urea is an ATP competitive inhibitor of Flt3 with ki of 0 12 M Besides FLT3 AST487 also inhibits RET KDR c-KIT and c-ABL kinase with IC50 values below 1 M
Selleck Chemical LLC Naringin S2329-1g
Naringin (Naringoside) is a flavanone glycoside which exerts a variety of pharmacological effects such as antioxidant activity blood lipid lowering anticancer activity and inhibition of cytochrome P450 enzymes