Flavonoids
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 50 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone, with potential for hepatic steatosis and dyslipidemia research.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
Medchemexpress LLC Flavanone | 487-26-3 | 1 ML
Flavanone is a naturally occurring flavone with inhibitory activity for human estrogen synthetase (aromatase) and acts as an inhibitor for the ERK/p38/NF-κB signaling pathway. It exhibits oral activity and antitumor efficacy, demonstrating its potential in various biological processes.
- Inhibits cell proliferation, migration, and invasion of A549 cells
- Arrests cell cycle at G1 phase in vitro
- Inhibits expression of MMP-2, u-PA, cyclin D1, and CDK2
- Promotes generation of TIMP-2 and PAI-1
- Exhibits antitumor efficacy in C57BL/6J mouse models
- Limits tumor growth and inhibits metastasis of LLC cells in vivo
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 25 MG
Luteolin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) activities. It is a solid, white to light yellow in color, and is intended for research use only. This compound inhibits NO production and mRNA expression of various inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
- Inhibits matrix metalloproteinases (MMP) activities
- Inhibits NO production and mRNA expression of inflammatory mediators
- Improves depression-like and stress coping behaviors in mouse models
- Available as a white to light yellow solid
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Luteolin 98 TLC powder50MG
Luteolin (3AE 4AE 5AE 7AE-tetrahydroxyflavone) a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery green peppers and chamomile tea. Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss aerial part of Dracocephalum kotschyi and contributes to the antioxidant potential of the plant. Luteolin possesses antioxidant anti-inflammatory properties and exerts anti-tumor potential primarily through apoptosis. Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics. Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production. The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer disease. In plants luteolin induces nodu
Apexbio Technology LLC (-)-epicatechin gallate 1257-08-5 20mg
(-)-Epicatechin gallate (ECG) is a catechin compound abundant in green tea displaying bioactivity to modulate cell proliferation apoptosis and gene expression pathways In colon HCT-116 cells ECG induces apoptosis through activating transcription factor 3 (ATF3) regulated via activation of early growth response protein 1 (EGR-1) In these cancer cells ECG upregulates apoptotic factor NAG-1 and increases caspase-3 activity at concentrations around 150 M ECG s cytotoxic potency differs among cell types with an NR50 (midpoint cytotoxic concentration) of approximately 67 M in HSC-2 oral cancer cells while normal human fibroblast HGF-2 cells show greater resistance with an NR50 near 100 M ECG metabolites identified in rat urine include various O-methylated derivatives useful as biomarkers for metabolism studies ECG serves as a research tool for oncology mechanisms and apoptosis signaling pathways
TARGETMOL CHEMICALS INC Apigenin 200MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication. Apigenin has not been implicated in causing serum enzyme elevations or clinically apparent liver injury. Purity 99.66%
Apexbio Technology LLC (-)-epicatechin 490-46-0 5mg
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
AdipoGen Luteolin
Chemical. CAS 491-70-3. Formula C15H10O6. MW 286.24. Luteolin is a hydroxylated flavone derivative that is a strong antioxidant and radical scavenger. It has multiple activities, such as anticancer, antimetastatic, anti-adipogenic, anti-inflammatory and neuroprotective. Luteolin has been described as a fatty acid synthase FASN, 15-lipoxygenase, alpha-glucosidase, PPAR-gamma, topoisomerase I, PI3K/Akt, RSK1/RSK2 and HDAC inhibitor.
Cayman Chemical LuteolIn 7-O-GlucuronIde 10mg
A flavonoid with antioxidant, enzyme inhibitory, and anti-inflammatory properties; scavenges DPPH radicals in a cell-free assay (IC50 = 80.6 μM); inhibits porcine α-amylase and yeast α-glucosidase in vitro (IC50s = 61.5 and 14.7 μM, respectively); inhibits rat aldose reductase in vitro (IC50 = 0.7 μM) and sorbitol accumulation in isolated rat lens at 5 μg/ml; inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
Sigma Aldrich Fine Chemicals Biosciences (−)-Epicatechin | 490-46-0 | MFCD00075648 | 1mg
(−)-Epicatechin | Purity: 98% | MW: 290.27 | 490-46-0 | MFCD00075648 | 1mg
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 | C15H12O3 | 100 MG
3′-Hydroxyflavanone is a cyclized flavanone research compound reported to induce apoptosis in HeLa cells and to possess antitumor activity. It is intended for in vitro biochemical and cellular studies and is supplied with an accompanying datasheet for characterization and safety information.
- Cyclized flavanone structure suitable for flavonoid research.
- Reported to induce apoptosis in HeLa cells.
- Reported antitumor activity in literature.
- Available in multiple pack sizes from milligram to gram quantities.
- Supplied in high-purity grades with supporting datasheet.
TARGETMOL CHEMICALS INC PHILLYRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Phillyrin (Forsythin) is a novel AMPK activator has anti-obesity effects in nutritive obesity mice it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting it potentially contributes to the suppression of the activation of MAPK and NF-(kappa)B pathways it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells. purity: 99%