Flavonoids
Sigma Aldrich Fine Chemicals Biosciences Luteolin 98 TLC powder50MG
Luteolin (3AE 4AE 5AE 7AE-tetrahydroxyflavone) a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery green peppers and chamomile tea. Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss aerial part of Dracocephalum kotschyi and contributes to the antioxidant potential of the plant. Luteolin possesses antioxidant anti-inflammatory properties and exerts anti-tumor potential primarily through apoptosis. Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics. Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production. The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer disease. In plants luteolin induces nodu
Medchemexpress LLC Apigenin-7-glucuronide | 29741-09-1 | 446.36 | 1 ML
Apigenin-7-glucuronide is a chemical compound that acts as an inhibitor of Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-3, MMP-8, MMP-9, and MMP-13. This product is intended for research use only.
- Inhibits Matrix Metalloproteinases (MMP) activities
- Purity of 99.74%
- Available as a solid
- Soluble in DMSO for in vitro studies
- Specific storage conditions for powder and in solvent
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 25 MG
Luteolin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) activities. It is a solid, white to light yellow in color, and is intended for research use only. This compound inhibits NO production and mRNA expression of various inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
- Inhibits matrix metalloproteinases (MMP) activities
- Inhibits NO production and mRNA expression of inflammatory mediators
- Improves depression-like and stress coping behaviors in mouse models
- Available as a white to light yellow solid
- For research use only
Cayman Chemical EpIcatechIn 10mg
A polyphenol flavonoid with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 5 µM; inhibits COX-1 (IC50 = 3.2 μM); acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 cells at 200 µM; reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation at 80 mg/kg
Medchemexpress LLC Apigenin | 520-36-5 | 270.24 | 5 MG
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM. It inhibits cell proliferation in SGC-7901 cells in a dose- and time-dependent manner and possesses a broad spectrum of biological properties including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects.
- Inhibits cell proliferation
- Suppresses clone formation of SGC-7901 cells
- Alleviates adriamycin-induced myocardial injury
- Reduces serum aspartate amino transferase release
- Reduces serum lactate dehydrogenase release
- Reduces serum creatine kinase contents
Medchemexpress LLC (+)-epicatechin (dexepicatechin) | 35323-91-2 | MFCD00075648 | 99.6% | 10 MG
(+)-Epicatechin is a chiral catechin and polyphenolic antioxidant supplied as a research reagent. It is commonly used in biochemical and analytical assays to evaluate antioxidant activity and enzyme inhibition. The compound is a white to off-white solid with molecular formula C15H14O6 and a molecular weight of 290.27 g/mol. Purity is typically reported at about 99.6%.
- High purity suitable for analytical applications
- Solid form convenient for storage and handling
- Used in antioxidant and cyclooxygenase inhibition studies
- Soluble in common organic solvents for stock solutions
- Provided in a small quantity suitable for early-stage experiments
Medchemexpress LLC Luteolin | 491-70-3 | 99.5% | 286.24 | 50 MG
Luteolin is a flavonoid compound that acts as a potent Nrf2 inhibitor. It exhibits anti-inflammatory and anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in various cancer cell lines such as human non-small lung cancer cells.
- Potent Nrf2 inhibitor.
- Possesses anti-inflammatory properties.
- Demonstrates anti-cancer effects, including inducing apoptosis and cell cycle arrest.
- Inhibits metastasis and angiogenesis in several cancer cell lines.
Cayman Chemical LuteolIn 7-O-RutInosIde 10mg
A flavonoid glycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay from 1-50 µM; active against various bacteria (MICs = 100-200 UG/ml); active against C. albicans, S. cerevisiae, and C. lusitaniae (MICs = 100, 200, and 50 UG/ml, respectively); decreases hepatic and renal injury and increases survival in a mouse model of polyphosphate-induced lethal endotoxemia at 57.6 UG/animal
TARGETMOL CHEMICALS INC APIGENIN 7-GLUCOSIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion tyrosine phosphorylation of insulin receptor-(beta) and GLUT4 translocation. purity: 99%
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mM (in 1mL DMSO)
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mg
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
Medchemexpress LLC 4H-1-benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- | 520-36-5 | 270.24 | 200 MG
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM. It inhibits cytochrome P450 2C9 (CYP2C9) with a Ki of 2 μM in the CYP2C9 RECO system, a purified, reconstituted enzyme system. This natural flavonoid possesses broad biological properties including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects.
- Inhibits cell proliferation
- Suppresses clone formation of SGC-7901 cells
- Alleviates Adriamycin-induced myocardial injury
- Reduces serum aspartate amino transferase (AST) release
- Reduces serum lactate dehydrogenase (LDH) release
- Reduces serum creatine kinase (CK) contents