Reactive Nonmetal Salts
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Medchemexpress LLC ((1R,2S,4R)-4-((5-(1-(3-bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate | 1644342-14-2 | 99.8% | 551.41 | 1 ML
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ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays with IC50 values of 3 and 11 nM, respectively. It shows significantly less activity against NAE/NEDD8 and UAE/ubiquitin. This compound inhibits SAE and SUMO-pathway activities in HCT116 cells, and decreases cancer cell viability in various cancer cell lines. This compound is for research use only.
- Potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2.
- Inhibits SAE and SUMO-pathway activities in HCT116 cells.
- Inhibits cell proliferation and decreases cancer cell viability in various cancer cell lines (MDA-MB-468, MDA-MB-231, HCT116, Colo-205, and A375).
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Enzo Life Sciences MnTMPyP. pentachloride (10mg)
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Cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Catalyzes the dismutation of O2- even in the presence of excess EDTA. Displays a protective effect against H2O2 mediated injury in astroglial cells. Purity: ≥95% (TLC). Solubility: Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)). Long Term Storage: -20°C.
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Enzo Life Sciences MnTMPyP. pentachloride (50mg)
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Cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Catalyzes the dismutation of O2- even in the presence of excess EDTA. Displays a protective effect against H2O2 mediated injury in astroglial cells. Purity: ≥95% (TLC). Appearance: Black crystalline powder. Solubility: Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)). Long Term Storage: -20°C.
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AdipoGen MnTMPyP pentachloride
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Chemical. CAS 100012-18-8. Formula C44H36MnN8Cl5. MW 909. Cell permeable superoxide dismutase SOD mimetic. Peroxynitrite scavenger. Displays a protective effect against H2O2 mediated injury. Neuroprotective. Oxidative stress inhibitor. Apoptosis inhibitor. Reduces inflammation.
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Medchemexpress LLC Hh-Ag1.5 (SAg1.5) | 612542-14-0 | ≥98.0% | 526.04 | C28H26ClF2N3OS | 10MG
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Hh-Ag1.5 is a small-molecule agonist of the Hedgehog signaling pathway that activates Smoothened (Smo) and induces Gli-dependent transcription. It is used in vitro to stimulate Hh signaling, with reported activity at subnanomolar concentrations and documented application in reprogramming and expansion of quiescent liver stem cells.
- Potent Hedgehog pathway agonist with EC50 ≈ 1 nM.
- Selective Smoothened (Smo) receptor agonist with Ki ≈ 0.52 nM.
- Facilitates expansion of quiescent liver stem cells in vitro at 5 μM.
- High purity suitable for cellular assays (≥98% by HPLC).
- Molecular weight 526.04; formula C28H26ClF2N3OS; soluble in DMSO.
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Medchemexpress LLC ML-792 | 1644342-14-2 | 99.8% | 551.41 | 50 MG
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ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays, with IC50 values of 3 nM and 11 nM, respectively. It demonstrates significantly less activity against NAE/NEDD8 and UAE/ubiquitin. This product is for research use only.
- Potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2.
- IC50 values of 3 nM for SAE/SUMO1 and 11 nM for SAE/SUMO2.
- Significantly less activity against NAE/NEDD8 and UAE/ubiquitin.
- Purity: 99.76%.
- CAS number: 1644342-14-2.
- Molecular weight: 551.41.
- Appearance: solid, white to off-white.
- Inhibits SAE and SUMO-pathway activities in HCT116 cells.
- Inhibits cell proliferation and decreases cancer cell viability.
- Demonstrates dose-dependent viability effect.
- Revealed dose-dependent decrease in SAE and UBC9 thioester levels.
- Soluble in DMSO: 100 mg/mL (181.35 mM).
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Medchemexpress LLC Gypsogenin | 639-14-5 | 99.5% | 5 MG
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Gypsogenin is an oleanane-type triterpenoid shown to have antiangiogenic activity and significant cytotoxicity against H460 cells. It is supplied as a solid research reagent, typically dissolved in DMSO for biological assays and stored protected from light.
- Natural triterpenoid with antiangiogenic activity.
- Shows significant cytotoxicity against H460 cell line.
- Empirical formula C30H46O4 and molecular weight 470.7 g/mol.
- Purity typically 99.5% as supplied.
- Soluble in DMSO at 25 mg/mL; ultrasonic assistance recommended.
- Storage: 4°C protected from light; in solvent store at -80°C up to 6 months.
- Supplied as a 5 mg solid suitable for laboratory research use.
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Medchemexpress LLC Yangambin | 13060-14-5 | MFCD04307767 | 5 MG
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Yangambin is a furofuran lignan isolated from various plants. It functions as a selective PAF receptor antagonist and inhibits Ca2+ influx through voltage-gated Ca2+ channels, reducing intracellular Ca2+ in vascular smooth muscle cells, which leads to peripheral vasodilation. This compound also exhibits antiallergic and anti-inflammatory activities.
- Selective PAF receptor antagonist
- Inhibits Ca2+ influx through voltage-gated Ca2+ channels
- Reduces intracellular Ca2+ in vascular smooth muscle cells
- Demonstrates antiallergic activity (IC50 of 33.8 μM)
- Demonstrates anti-inflammatory activity (IC50 of 37.4 μM)
- Purity: 98.27%
- Molecular weight: 446.49
- Formula: C24H30O8
- Appearance: Solid, white to off-white
- For research use only
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Medchemexpress LLC Gypsogenin | 639-14-5 | 99.5% | 25 MG
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Gypsogenin is a pentacyclic triterpenoid sapogenin (CAS 639-14-5) used for research. It has molecular formula C30H46O4 and a molecular weight of 470.68 g/mol, and is reported to show antiangiogenic activity and cytotoxicity against H460 cells. Typically supplied as a 25 mg research sample.
- High purity (≈99.5%).
- Soluble in DMSO (25 mg/mL); may require sonication and freshly opened DMSO.
- Recommended storage: 4°C; in solvent, -80°C (6 months) or -20°C (1 month); protect from light.
- Intended for research use; not for human or clinical use.
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Medchemexpress LLC IR415 25mg | 452967-14-5 | 296.34 | C13H14F2N4S | 25 MG
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IR415 is a research compound that inhibits hepatitis B virus (HBV) replication by blocking HBx activity. It selectively binds HBx (reported Kd = 2 nM) and reverses HBx-mediated suppression of RNA interference; characterized for dose-dependent inhibition of HBx in vitro.
- Selective HBx inhibitor (Kd = 2 nM).
- Demonstrated dose-dependent inhibition of HBx activity in cell assays.
- Chemical formula C13H14F2N4S; molecular weight 296.34.
- High purity (reported ≥98% by HPLC).
- Available as a powdered research reagent; store powder at -20°C for long-term stability.
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Medchemexpress LLC Bigelovin 5mg | 3668-14-2 | 304.34 g/mol | C17H20O5 | 5 MG
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Bigelovin is a sesquiterpene lactone research compound used to induce apoptosis and autophagy through reactive oxygen species-mediated inhibition of mTOR signaling. It is supplied for in vitro research use and is provided in small, high-purity quantities with specified storage conditions to preserve stability.
- Induces apoptosis and autophagy via ROS-mediated mTOR pathway inhibition.
- High purity suitable for in vitro research (product page lists 99.92%).
- Molecular formula C17H20O5; molecular weight 304.34 g/mol.
- Provided in small-quantity vials appropriate for cell-based assays and biochemical studies.
- Store protected from light; refrigerated storage recommended; in solution store at low temperatures per datasheet.
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Medchemexpress LLC Yangambin | 13060-14-5 | MFCD04307767 | 98.3% | 446.49 | C24H30O8 | 10 MG
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Yangambin is a furofuran lignan supplied for laboratory research that functions as a calcium-channel inhibitor and platelet-activating factor (PAF) receptor antagonist. It reduces intracellular Ca2+ in vascular smooth muscle cells and has reported antiallergic and anti-inflammatory activity in vitro.
- Acts as a calcium-channel inhibitor and PAF receptor antagonist.
- Shows antiallergic and anti-inflammatory activity in vitro.
- High purity (≈98.3%), suitable for biochemical and pharmacological assays.
- Soluble in DMSO (50 mg/mL) and compatible with several in vivo formulations (≥1.25 mg/mL reported).
- Furofuran lignan chemical class, C24H30O8, MW 446.49 Da.
- Store at 4°C protected from light; in solution store at -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thi | 612542-14-0 | MFCD12032128 | 99.9% | 526.04 | C28H26ClF2N3OS | 25MG
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Hh-Ag1.5 (SAg1.5) is a potent small-molecule agonist of the Hedgehog signaling pathway that activates the Smoothened (Smo) receptor. It is supplied as a white to off-white solid with high reported purity and is used as a research tool to activate Hh signaling in cellular and in vivo studies. The compound is highly soluble in DMSO and has documented storage recommendations for powder and solutions.
- Potent Hedgehog pathway agonist with EC50 ≈ 1 nM.
- Activates Smoothened to induce downstream GLI transcription activity.
- High purity suitable for research (99.9%).
- Soluble in DMSO at 50 mg/mL; in vivo formulations achievable at ≥2.5 mg/mL.
- Stable as powder when stored cold; aliquot solutions to avoid freeze-thaw.
- Demonstrated biological activity in liver stem cell expansion at 5 μM in vitro.
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Medchemexpress LLC 3-chloro-4,7-difluoro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophen | 612542-14-0 | 99.9% | 526.04 | C28H26ClF2N3OS | 50MG
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Hh-Ag1.5 is a potent small-molecule agonist of the Hedgehog signaling pathway (EC50 ≈ 1 nM) for use in in vitro and in vivo pathway activation and stem-cell reprogramming studies. Supplied as a white to off-white solid at high purity, it is formulated for research and preclinical applications.
- Potency: EC50 1 nM (Hedgehog)
- CAS number: 612542-14-0
- Molecular formula: C28H26ClF2N3OS
- Molecular weight: 526.04
- Purity: 99.9%
- Appearance: white to off-white solid
- Solubility: DMSO 50 mg/mL (use fresh DMSO; ultrasonic may be required)
- Storage: powder -20°C (3 years), 4°C (2 years)
- Typical pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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