Carboxylic acids and derivatives
Medchemexpress LLC PF-543 Citrate | 1415562-83-2 | C33H39NO11S | 1 ML
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible, and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. It demonstrates over 100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. It is known to induce apoptosis, necrosis, and autophagy.
- Potent, selective, reversible, and sphingosine-competitive SPHK1 inhibitor
- IC50 of 2 nM and Ki of 3.6 nM for SPHK1
- Over 100-fold selectivity for SPHK1 over SPHK2
- Effective inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM
- Induces apoptosis, necrosis, and autophagy
Medchemexpress LLC YS-49 monohydrate | 3028631-24-2 | C20H22BrNO3 | 5 MG
YS-49 monohydrate is a PI3K/Akt activator that reduces RhoA/PTEN activation in 3-methylcholanthrene-treated cells. It inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1 and acts as an isoquinoline compound alkaloid with strong positive inotropic action through activation of cardiac β-adrenoceptors.
- Activates PI3K/Akt pathway
- Reduces RhoA/PTEN activation
- Inhibits angiotensin II-stimulated proliferation of VSMCs
- Induces heme oxygenase (HO)-1
- Exhibits strong positive inotropic action via cardiac β-adrenoceptor activation
Selleck Chemical LLC Zoledronic acid monohydrate S5244-25mg
Zoledronic acid (Zoledronate CGP-4244) monohydrate a nitrogen-containing bisphosphonate is a potent osteoclast inhibitor which induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho
Accela Chembio Inc Triethyl Methanetricarboxylate | 100g | 6279-86-3 | MFCD00009150 | 95+% | D: 1.095 | Shelf Life: 1080 Days | Regular
Triethyl Methanetricarboxylate | 100g | 6279-86-3 | MFCD00009150 | 95+% | D: 1.095 | Shelf Life: 1080 Days | Regular
Medchemexpress LLC 2'-deoxyuridine-5'-triphosphate trisodium salt | 102814-08-4 | MFCD00084701 | 99.7% | 534.09 | C9H12N2Na3O14P3 | 5 MG
dUTP trisodium (2'-deoxyuridine-5'-triphosphate trisodium salt) is the trisodium salt of dUTP, a deoxynucleotide triphosphate used as a dTTP substitute in PCR and related enzymatic applications to produce uracil-containing DNA. Supplied as a solid with high reported purity, it is intended for workflows that require uracil incorporation or UDG-based carryover prevention.
- High purity (99.74%) suitable for sensitive enzymatic reactions.
- Provided as a white to off-white solid, 5 mg pack size.
- Trisodium salt form for stable handling and solubility.
- Compatible with PCR and RT-PCR to produce uracil-containing PCR products.
- Supports uracil-DNA glycosylase (UDG)-based carryover prevention.
- Store sealed, away from moisture; in solution: -80°C (up to 6 months), -20°C (up to 1 month).
Medchemexpress LLC KDOAM-25 citrate | 2448475-08-7 | MFCD00865590 | >98.0% | 499.51 g/mol | C21H33N5O9 | 1 ML
KDOAM-25 citrate is the citrate salt of a potent, selective inhibitor of KDM5 family histone lysine demethylases. It is supplied as a solid or as a 10 mM solution in DMSO (1 mL) and is intended for use in biochemical and cellular research probing KDM5 activity and epigenetic regulation.
- Potent, selective KDM5 inhibitor with low-nanomolar IC50 values.
- Available as solid or 10 mM solution in DMSO (1 mL).
- High purity (>98% by HPLC/LCMS).
- Molecular weight 499.51 g/mol; formula C21H33N5O9.
- Suitable for biochemical assays and cellular studies.
- Soluble in DMSO for convenient stock preparation.
Apexbio Technology LLC Lithium Citrate,100g CAS# 6080-58-6
Lithium Citrate is the active component of Lithium which is a drug used in treatment of psychiatric disease [1].Lithium Citrate has shown the effects on metabolic and signaling pathways in the brain based on the specific clinical condition and disease model [2]. Lithium Citrate has been reported to use as a mood stabilizer when treating bipolar mood disorders (BD) and reduce the risk of self-harm in BD patient. In addition, Lithium Citrate has been found to be the choice drug in treatment of acute manic episodes. Moreover, Lithium Citrate has been revealed to dissolve uric acid crystals in urine obtained from patients with gout. Besides, Lithium Citrate has been exhibited to have some dose-dependent side-effects. The most of the side-effects of Lithium Citrate is the tendency to inhibit the prostatic acid phosphatase enzyme (PAP), which leading to the accumulation of PAP [1]. Other sizes are also available. Please inqury us for quote.
eMolecules 4079-68-9 | N,N-DIETHYLPROPARGYLAMINE | AstaTech | MFCD00039881 | 111.188 | C7H13N | 95.000 | CCN(CC)CC#C | 5g | 454893684
N,N-DIETHYLPROPARGYLAMINE | AstaTech | 4079-68-9 | MFCD00039881 | 111.188 | C7H13N | 95.000 | CCN(CC)CC#C | 5g | 454893684
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 250 MG
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
Medchemexpress LLC SPD-473 citrate | 161190-26-7 | 99.8% | 552.47 g/mol | C23H31Cl2NO8S | 5 MG
SPD-473 citrate is the citrate salt of a small-molecule triple reuptake inhibitor that blocks serotonin, dopamine, and norepinephrine transport. It is supplied as a solid research chemical for in vitro and in vivo neuroscience and pharmacology studies and is accompanied by analytical and safety documentation.
- Triple reuptake inhibitor activity for serotonin, dopamine, and norepinephrine.
- Citrate salt form supplied as a solid.
- Supplied in small research quantities (1-100 mg) suitable for laboratory studies.
- High purity: 99.8%.
- Analytical data and documentation available, including data sheet, SDS, COA, HNMR, and LCMS.
Medchemexpress LLC (E/Z)-zotiraciclib citrate | 1204918-73-9 | 99.8% | 564.59 g/mol | C29H32N4O8 | 10 MG
(E/Z)-Zotiraciclib citrate is the citrate salt form of zotiraciclib, a small-molecule kinase inhibitor active against CDK2, JAK2, and FLT3. It is supplied as an off-white to light yellow solid for laboratory research use, and is characterized by high purity and defined storage guidance for both solid and solution forms.
- Potent inhibitor of CDK2, JAK2, and FLT3, suitable for kinase research.
- Citrate salt form with molecular weight 564.59 g/mol.
- Chemical formula C29H32N4O8.
- High purity (≈99.8%), appropriate for biochemical and cell-based assays.
- Solid physical form: off-white to light yellow powder.
- Recommended storage sealed, away from moisture; freeze solutions for long-term storage.
- Offered in multiple pack sizes, including small milligram quantities and solution formats for convenience.
![eMolecules 68-04-2 | Sodium citrate, anhydrous | Oakwood Chemical | MFCD00012462 | 258.068 | C6H5Na3O7 | 99.000 | [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 25g | 866847505](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000470643.jpg-250.jpg)
eMolecules 68-04-2 | Sodium citrate, anhydrous | Oakwood Chemical | MFCD00012462 | 258.068 | C6H5Na3O7 | 99.000 | [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 25g | 866847505
Sodium citrate, anhydrous | Oakwood Chemical | 68-04-2 | MFCD00012462 | 258.068 | C6H5Na3O7 | 99.000 | [Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | 25g | 866847505
Medchemexpress LLC IACS-8803 diammonium | 00-00-0 | 96.7% | C20H29FN12O9P2S2 | 10MG
IACS-8803 (diammonium) is a cyclic dinucleotide STING agonist supplied as a diammonium salt for research use. It potently activates the STING pathway and has demonstrated robust systemic antitumor efficacy in preclinical studies. The diammonium salt improves handling and stability compared with the free form and is intended for in vitro and in vivo immuno-oncology research.
- Potent STING pathway agonist for immune activation.
- Demonstrated systemic antitumor efficacy in preclinical models.
- Suitable for in vitro and in vivo research applications.
- Diammonium salt formulation for improved stability and handling.
- Requires cold-chain storage; research use only.
Medchemexpress LLC Citrate synthase | 9027-96-7 | ~98 KDa dimer (49 KDa monomer) | 1000 U
Citrate synthase catalyzes the initial reaction of the citric acid cycle, facilitating the condensation of acetyl-CoA and oxaloacetate to produce citrate. This enzyme is primarily found within the mitochondrial matrix of eukaryotic cells.
- Catalyzes the condensation of acetyl-CoA and oxaloacetate
- Forms citrate, initiating the citric acid cycle
- Localized in the mitochondrial matrix of eukaryotic cells
- Specific activity of ≥100 U/mg protein
- Unit defined as 1.0 μmole of citrate formed per minute at pH 8.0 at 37°C
- Liquid appearance
- Colorless to light yellow
- Molecular weight of ~98 KDa dimer (49 KDa monomer)
Apexbio Technology LLC trans-Aconitic acid 4023-65-8 5g
trans-Aconitic acid (CAS 4023-65-8) is an unsaturated tricarboxylic acid endogenously detected in human urine It serves as a substrate for trans-aconitate 2-methyltransferase implicating it in metabolic pathways related to citrate metabolism Elevated urinary levels of trans-aconitic acid have been observed in conditions such as Reye s syndrome and certain organic acidurias suggesting its potential as a metabolic biomarker This compound is utilized in biomedical research to investigate metabolic dysregulation and to study enzyme-substrate interactions within organic acid metabolism