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Bromobenzenes

Organic compounds considered aryl halides that consist of a phenyl group with a bromine atom substitution in the following structure: C₆H₅Br.

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1

Medchemexpress LLC TMBIM6 antagonist-1 | 123134-61-2 | 98.9% | 268.27 | 50 MG
SDP

TMBIM6 antagonist-1 is a potential TMBIM6 antagonist. It prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and regulates TMBIM6-leaky Ca2+. This product is for research use only.

  • Inhibits cell viability in HT1080, MCF7, MDA-MB-2341, and SKBR3 cells
  • Decreases cell migration in HT1080, MCF7, MDA-MB-231, and SKBR3 cells
  • Downregulates AKT-pS473 protein levels
  • Significantly impairs cell-driven tumor growth in vivo

ENCOMPASS_PREFERRED
2

Medchemexpress LLC 2,3-dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one | 1204401-49-9 | >=98.0% | 337.48 | C21H23NOS | 5 MG
SDP

σ1 Receptor antagonist-1 (CAS 1204401-49-9) is a selective sigma-1 receptor antagonist provided for research use. It has been reported to inhibit cell growth, cause G0/G1 cell cycle arrest, and induce apoptosis in certain cancer cell lines. The compound is supplied as a solid and is intended for in vitro pharmacology and receptor biology studies.

  • Selective sigma-1 receptor antagonist.
  • Demonstrated to inhibit cell growth and induce G0/G1 cell cycle arrest and apoptosis in cell assays.
  • High purity (≥98% by HPLC).
  • Molecular weight 337.48 g/mol.
  • Chemical formula C21H23NOS.
  • Solid form, light yellow to light brown.
  • Recommended storage: powder at -20°C for long-term stability.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC 4H-1-benzothiopyran-4-one, 2,3-dihydro-2-[1-(phenylmethyl)-4-piperidinyl]- | 1204401-49-9 | MFCD18206882 | 99.9% | 337.48 g/mol | C21H23NOS | 10 MG
SDP

σ1 Receptor antagonist-1 is a potent and selective sigma-1 receptor antagonist provided as a solid research chemical for in vitro studies. It has high reported affinity for the σ1 receptor and has been used in cell-based assays to inhibit cell growth, induce apoptosis, and arrest the cell cycle. Analytical data and handling information are provided by the supplier; this compound is for research use only.

ENCOMPASS_PREFERRED
4

Selleck Chemical LLC Histone Acetyltransferase Inhibitor II S1161-5mg
SDP

Histone Acetyltransferase Inhibitor II (HAT Inhibitor II compound 2c) is a potent selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 M Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells

ENCOMPASS_PREFERRED
5

Selleck Chemical LLC BCI-121-5mg
SDP

BCI-121 is a potent inhibitor of SMYD3 that impairs the proliferation of many kinds of cancer cells.

ENCOMPASS_PREFERRED
6

Medchemexpress LLC Selumetinib (sulfate) | 943332-08-9 | 99.6% | C17H17BrClFN4O7S | 500 MG
SDP

Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).

  • Selective, non-ATP-competitive oral MEK1/2 inhibitor
  • Inhibits ERK1/2 phosphorylation
  • Can penetrate the blood-brain barrier (BBB)
  • Causes time- and dose-dependent reduction in DNA synthesis and cell viability
  • Induces growth arrest and apoptosis by inactivating ERK in primary cells
  • Shows anti-proliferative effects through G0/G1 arrest on H-441 and H-1437 cells
  • Inhibits growth of several cell lines with B-Raf and Ras mutations

ENCOMPASS_PREFERRED
7

Medchemexpress LLC GAK inhibitor 49 hydrochloride | 2930378-91-7 | 99.5% | 406.86 | C20H23ClN2O5 | 10MG
SDP

GAK inhibitor 49 hydrochloride is the hydrochloride salt of a potent, ATP-competitive inhibitor of cyclin G-associated kinase (GAK) used for biochemical and cell-based research. It shows subnanomolar biochemical potency (Ki = 0.54 nM), low-nanomolar cellular activity (cell IC50 = 56 nM), and reported binding to RIPK2. Supplied as a high-purity solid for laboratory assays.

  • Potent ATP-competitive inhibition of cyclin G-associated kinase.
  • Hydrochloride salt form for improved solubility and handling.
  • High purity typically ≥99.5% for research applications.
  • Suitable for biochemical kinase assays and cell-based target validation.
  • Available in milligram-scale quantities for research use.

ENCOMPASS_PREFERRED
8

Medchemexpress LLC Bcl-xL antagonist 2 | 1235032-75-3 | 98.9% | 100 MG
SDP

Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL, with an IC50 of 0.091 μM and a Ki of 65 nM. This compound promotes the apoptosis of cancer cells and is considered to have potential for research related to chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).

  • Potent and selective BCL-XL antagonist
  • Orally active
  • Promotes apoptosis of cancer cells
  • Potential for chronic lymphocytic leukemia (CLL) research
  • Potential for non-Hodgkin's lymphoma (NHL) research

ENCOMPASS_PREFERRED
9

Medchemexpress LLC 4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid | 1021497-97-1 | MFCD30738005 | >=98.0% | 460.34 g/mol | C20H18BrN3O3S | 25 MG
SDP

KR-33493 is a small-molecule inhibitor of Fas-associated factor 1 (FAF1) that blocks Fas-mediated cell death and is used as a research tool to probe TNF receptor-related apoptosis pathways and evaluate neuroprotective mechanisms in preclinical studies.

  • Potent inhibition of Fas-mediated cell death.
  • Useful probe for apoptosis and TNF receptor pathway studies.
  • Applicable in preclinical neuroprotection research.
  • Stable as a powder when stored at low temperatures.
  • Provided in small milligram quantities suitable for laboratory assays.

ENCOMPASS_PREFERRED
10

Medchemexpress LLC SB225002 | 182498-32-4 | 99.9% | 352.14 | 50 MG
SDP

SB225002 is a potent, selective, and non-peptide CXCR2 antagonist. It inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. This compound demonstrates high selectivity over CXCR1 and other 7-TMRs, acting as a potent antagonist of rabbit CXCR2 and inhibiting calcium mobilization. It has also shown to decrease cell proliferation in certain cell lines and block IL-8-induced neutrophil margination in vivo.

  • Potent, selective, and non-peptide CXCR2 antagonist
  • Inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM
  • Shows >150-fold selectivity over CXCR1
  • Inhibits IL-8 and GROα-mediated calcium mobilization
  • Decreases cell proliferation in vitro
  • Blocks IL-8-induced neutrophil margination in vivo
  • Attenuates microglial activation and BBB damage in vivo

ENCOMPASS_PREFERRED
11

Medchemexpress LLC Bcl-xL antagonist 2 | 1235032-75-3 | 98.86% | 10 MG
SDP

Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL, exhibiting IC50 and Ki values of 0.091 μM and 65 nM, respectively. This compound promotes the apoptosis of cancer cells and is being researched for its potential applications in chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).

  • Potent and selective BCL-XL antagonist
  • Orally active
  • Promotes apoptosis in cancer cells
  • Potential for chronic lymphocytic leukemia (CLL) research
  • Potential for non-Hodgkin's lymphoma (NHL) research

ENCOMPASS_PREFERRED
12

Medchemexpress LLC Kinesore | 363571-83-9 | 98.0% | 536.17 | 50 MG
SDP

Kinesore is an inhibitor of the KLC2-SKIP Interaction. It induces the reorganization of the microtubule network and the formation of extensive microtubule-rich projections, and this effect is dependent upon the presence of kinesin-1. The effect is reversible. This reorganization is observed in a panel of mammalian normal and cancer cell lines.

  • Inhibitor of the KLC2-SKIP Interaction
  • Reorganizes the microtubule network into loops and bundles
  • Accumulates the lysosomal compartment in a juxtanuclear position
  • Effect is apparent at 25 μM and reversible
  • Observed in various mammalian normal and cancer cell lines
  • Microtubule remodeling is dependent on kinesin-1

ENCOMPASS_PREFERRED
13

Medchemexpress LLC 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile | 65678-07-1 | MFCD02179365 | >98.0% | 305.17 g/mol | C14H13BrN2O | 100 MG
SDP

AG1024 (Tyrphostin AG 1024) is a small-molecule, reversible inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) used in cell signaling and cancer research. It inhibits IGF-1R autophosphorylation and can modulate insulin receptor activity; the material is supplied as a powder for laboratory use.

  • Reversible inhibitor of IGF-1R suitable for mechanistic studies.
  • Inhibits IGF-1R autophosphorylation and modulates insulin receptor signaling.
  • High purity suitable for cell-based and biochemical assays.
  • Powder form with good solubility in DMSO for solution preparation.
  • Provided in research-scale quantities for laboratory testing.

ENCOMPASS_PREFERRED
14

Medchemexpress LLC Selumetinib (sulfate) | 943332-08-9 | C17H17BrClFN4O7S | 200 MG
SDP

Selumetinib (AZD6244) sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).

  • Inhibits ERK1/2 phosphorylation
  • Penetrates the blood-brain barrier
  • Reduces DNA synthesis and cell viability
  • Induces growth arrest and apoptosis
  • Shows anti-proliferative effects through G0/G1 arrest
  • Inhibits growth of cell lines with B-Raf and Ras mutations
  • Decreases growth rate of xenografts
  • Causes tumor regressions in xenograft models

ENCOMPASS_PREFERRED
15

Medchemexpress LLC Androgen receptor antagonist 1 | 1338812-36-4 | 99.7% | C21H25ClN4O3 | 10MG
SDP

Androgen receptor antagonist 1 is a small-molecule research compound (CAS 1338812-36-4) reported to act as a full androgen receptor antagonist used in preclinical studies and cell-based assays to probe AR signaling. The compound has molecular formula C21H25ClN4O3, molecular weight ~416.9 g·mol⁻¹, and is listed with high reported purity by commercial suppliers.

  • High reported purity (~99.7%) for reproducible results.
  • Full androgen receptor antagonist activity for AR pathway studies.
  • Suitable for cell-based and biochemical assays.
  • Soluble formulations available for convenient assay preparation.
  • Well-defined molecular properties (C21H25ClN4O3; MW ~416.9) for characterization.

ENCOMPASS_PREFERRED