Cyclohexylphenols
Medchemexpress LLC PB1 | 188714-28-5 | 99.5% | 296.11 | 50 MG
This is a potent intracellular disulfide reducing agent. It offers several advantages including good cell permeability, the ability to form a high intracellular concentration gradient, and stability. This agent is an analogue of a borane-protected compound and has been shown to increase retinal ganglion cell survival in vitro at very low concentrations. It can be used in research focused on neuroprotection.
- Good cell permeability.
- Ability to form a high intracellular concentration gradient.
- Stability.
- Increases retinal ganglion cell survival after axonal injury in vitro.
- Effective at rescuing acutely axotomized retinal ganglion cells.
- Attenuates the loss of both retinal ganglion cell soma and axons in experimental glaucoma.
Medchemexpress LLC Imifoplatin | 1339960-28-9 | 95.0% | 485.23 | 50 MG
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity.
- Inhibits proliferation in HCT116 cells.
- Induces apoptosis in HCT116 cells.
- Inhibits proliferation in CT26 cells.
- Shows selectivity, strongly inhibiting glycolytic tumor cells with mtDNA mutations.
- Increases mtROS, especially in glycolytic L929dt and Cybrid cells.
- Demonstrates potent antitumor immune effects in the CT26 xenograft model.
- Shows synergistic antitumor effects in the MC38 xenograft model, especially with PD-1 blockade.
Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-5',5''-dioxane-2'',3'''-[3H]indole]-2,2'''-dione | 442644-28-2 | MFCD03036757 | 98.15% | 394.38 | 10 MG
JW67 inhibits canonical Wnt signaling with an IC50 of 1.17 μM. It affects the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1, leading to a rapid reduction in active β-catenin and downregulation of Wnt target genes. This compound also inhibits colorectal cancer cell growth and reduces cell viability in SW480 cells.
- Inhibits canonical Wnt signaling with an IC50 of 1.17 μM
- Reduces active β-catenin and downregulates Wnt target genes
- Inhibits colorectal cancer cell growth
- Increases AXIN2 concentration and decreases active β-catenin in vitro
- Reduces colon cancer cell growth in vitro
- Shows concentration-dependent reduction in proliferation with a GI50 value of 7.8 μM
Medchemexpress LLC JW67 | 442644-28-2 | 98.15% | 394.38 | 50 MG
JW67 is a Wnt Signaling Inhibitor with an IC50 of 1.17 μM. It impacts the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1, leading to a rapid reduction in active β-catenin and downregulation of Wnt target genes. It also inhibits colorectal cancer cell growth.
- Inhibits canonical Wnt signaling
- Reduces active β-catenin
- Downregulates Wnt target genes
- Inhibits colorectal cancer cell growth
- Increases AXIN2 concentration
- Affects Wnt target gene expression
- Reduces cell growth in colon cancer cell lines
Medchemexpress LLC Borane-protected tris(2-carboxyethyl)phosphine analogue | 188714-28-5 | 99.5% | C14H22BO4P | 10MG
PB1 is a borane-protected tris(2-carboxyethyl)phosphine analogue that serves as a potent intracellular disulfide reducing agent. It exhibits good cell permeability and intracellular stability, and has been reported to improve retinal ganglion cell survival after axotomy in vitro at nanomolar and picomolar concentrations, making it suitable for neuroprotection and intracellular redox studies.
- Potent intracellular disulfide reducing agent.
- Borane-protected tris(2-carboxyethyl)phosphine analogue.
- Good cell permeability and intracellular stability.
- Capable of forming a high intracellular concentration gradient.
- Demonstrated neuroprotective effects in retinal ganglion cell assays at nM and pM ranges.
- Provided as a research-grade powder for biochemical applications.
Medchemexpress LLC Estradiol cypionate | 313-06-4 | MFCD00056558 | 99.5% | 500 MG
Estradiol cypionate is the 17β-cypionate ester of Estradiol, which inhibits ET-1 synthesis by acting on estrogen receptors.
- Inhibits proliferation of gastric cancer cells.
- Induces G1/S phase cell cycle arrest and apoptosis in gastric cancer cells.
- Increases protein levels of cleaved caspase-3 and PARP.
- Increases cortical bone density in ovariectomized rabbits.
- Increases the occurrence of estrus and pregnancy in cows.
- Inhibits tumor growth in MGC803 nude mice models.
Medchemexpress LLC PB1 | 188714-28-5 | 99.5% | 296.11 | 100 MG
PB1 is a potent intracellular disulfide reducing agent designed with good cell permeability and the ability to form a high intracellular concentration gradient, ensuring stability. It is a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue.
- Potent intracellular disulfide reducing agent
- Good cell permeability
- Forms high intracellular concentration gradient
- High stability
- Borane-protected TCEP analogue
- Increases retinal ganglion cell survival after axotomy in vitro
- Useful for neuroprotective research
Selleck Chemical LLC Estriol S2466-50mg
Estriol (NSC-12169) is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells
Medchemexpress LLC Trispiro[3H-indole-3,2'-dioxane-5',5''-dioxane-2'',3'''-[3H]indole]-2,2'''-dione | 442644-28-2 | 98.2% | 394.38 | 1 MG
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17 μM. It affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth.
- Inhibits canonical Wnt signaling with an IC50 of 1.17 μM.
- Affects the multiprotein complex of β-catenin/GSK-3β/AXIN/APC/CK1 to rapidly reduce active β-catenin.
- Downregulates Wnt target genes.
- Inhibits colorectal cancer cell growth.
- Increases concentration of AXIN2 and decreases the active form of β-catenin.
- Reduces cell growth of colon cancer cell lines.
- Shows a concentration-dependent reduction in proliferation with a GI50 value of 7.8 μM.
Medchemexpress LLC AAPK-25 | 2247919-28-2 | 98.1% | 442.32 g·mol⁻1 | C21H13Cl2N3O2S | 25MG
AAPK-25 is a small-molecule dual inhibitor of Aurora kinases and Polo-like kinases (PLKs) used for research into cell-cycle regulation and anti-tumor mechanisms. It induces mitotic delay and prometaphase arrest, increases histone H3 (Ser10) phosphorylation, and promotes apoptosis in responsive cell models.
- Dual Aurora and PLK inhibition with nanomolar affinity.
- Induces mitotic delay and prometaphase arrest.
- Validated in cell-based assays for apoptosis induction.
- Available as solid and DMSO solution formats for flexible use.
- Characterized chemical identity with confirmed purity and formula.
Medchemexpress LLC Aapk-25 | 2247919-28-2 | 98.1% | 442.32 | C21H13Cl2N3O2S | 100MG
AAPK-25 is a small-molecule dual inhibitor of Aurora kinases and Polo-like kinases (PLK) with reported antitumor activity; it induces mitotic delay and arrests cells in prometaphase. The compound has molecular formula C21H13Cl2N3O2S, a molecular weight of 442.32, and is supplied for research use at high purity.
- Dual Aurora and Polo-like kinase inhibition for cell-cycle studies.
- Induces mitotic delay and prometaphase arrest in cancer cell models.
- High research-grade purity for reproducible results.
- Well characterized molecular weight and formula for analytical workflows.
- Available in multiple research-scale package sizes for flexible use.
Medchemexpress LLC 6-(3,4-dichlorobenzamido)-N-(thiazol-2-yl)-2-naphthamide | 2247919-28-2 | 98.1% | 442.32 g/mol | C21H13Cl2N3O2S | 5MG
AAPK-25 is a potent, selective dual inhibitor of Aurora kinases and Polo-like kinases (PLK) used in preclinical research to investigate cell cycle regulation and anticancer mechanisms. It causes mitotic delay and arrests cells in prometaphase, and is provided as a solid or as a DMSO solution for cellular and biochemical assays.
- Potent dual inhibitor of Aurora kinases and PLK.
- Induces mitotic delay and prometaphase arrest in cells.
- Suitable for cellular and biochemical kinase assays.
- High purity (98.1%) for research applications.
- Available in solid and solution formats for flexible use.
- Simple storage guidance for sample stability in solution and solid forms.
Medchemexpress LLC Fraxinol | 486-28-2 | 5 MG
Fraxinol is a compound isolated from *Lobelia chinensis* that acts as a Cytochrome P450 Inhibitor. It exhibits cytotoxicity against human U937 cells with a CC50 > 2 mM and growth inhibition with an IC50 > 400 μM after 48 hours.
- Isolated from Lobelia chinensis
- Identified as a Cytochrome P450 inhibitor
- High purity of 98.82%
- Cytotoxicity against human U937 cells (CC50 > 2 mM)
- Growth inhibition of human U937 cells (IC50 > 400 μM)
- Molecular formula: C11H10O5
- Molecular weight: 222.19
- Appearance: Light yellow to yellow solid
- Recommended storage: 4°C, sealed, away from moisture and light
Medchemexpress LLC NU9056 | 1450644-28-6 | 98.8% | 232.37 | 1 MG
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an IC50 of 2 μM. It demonstrates over 16-fold selectivity for Tip60 compared to PCAF, p300, and GCN5. This compound is known to induce apoptosis in prostate cancer cells.
- Activates caspase 3 and caspase 9 in a time- and concentration-dependent manner.
- Decreases acetylated histone H4K16, H3K14, and H4K8 levels.
- Reduces androgen receptor, prostate-specific antigen, p53, and p21 protein levels.
- Induces apoptosis in LNCaP cells.
Medchemexpress LLC EZM0414 | 2411748-50-8 | 99.1% | C22H29FN4O2 | 50 MG
EZM0414 is a potent, selective, and orally bioavailable inhibitor of SETD2. It is used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, orally bioavailable inhibitor of SETD2
- IC50 of 18 nM in SETD2 biochemical assay
- IC50 of 34 nM in cellular assay
- Inhibits proliferation of MM and DLBCL cell lines
- Well-tolerated and inhibits tumor growth in xenograft models
- Almost 100% oral bioavailability in rats and mice
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