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Filtered Search Results
Medchemexpress LLC Tmx-4116 | 2766385-56-0 | 99.8% | C17H19N5O4S | 10MG
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TMX-4116 is a small-molecule degrader of casein kinase 1α (CK1α) intended for preclinical research. It selectively induces degradation of CK1α (DC50 <200 nM in MOLT4, Jurkat, and MM.1S cells), is supplied as a solid with analytical documentation, and includes recommended solubility and storage guidance.
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Medchemexpress LLC Apalutamide-cooh | 1332391-04-4 | 99.8% | C20H12F4N4O3S | 10MG
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Apalutamide-COOH is the carboxylic acid metabolite of apalutamide used as a reference standard in biochemical, pharmacokinetic, and analytical research. The compound is documented with CAS 1332391-04-4, formula C20H12F4N4O3S, and molecular weight 464.39; it is typically supplied as a high-purity powder for laboratory assays.
- High purity suitable for analytical standards.
- Useful as a reference metabolite in metabolism and PK studies.
- Applicable for androgen receptor-related biochemical assays.
- Stable under recommended storage conditions for long-term use.
- Supplied as a powder for flexible formulation and preparation.
- Molecular formula and molecular weight provided for documentation.
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Medchemexpress LLC 9H-Purine-2,8-diamine, 9-[(3R)-1-(cyclopropylsulfonyl)-3-pyrrolidinyl]-N2-[4-(4-methyl-1-pipera | 2463200-44-2 | 99.3% | C29H35N9O2S | 10MG
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EGFR-IN-11 is a fourth-generation EGFR tyrosine kinase inhibitor that selectively targets triple-mutant EGFR (L858R/T790M/C797S). It suppresses EGFR phosphorylation, induces apoptosis, and arrests cells in G0/G1; reported potency against the triple mutant is IC50 = 18 nM, and the compound is supplied for preclinical research.
- High potency against EGFR L858R/T790M/C797S (IC50 18 nM).
- Suppresses EGFR phosphorylation and induces apoptosis.
- Causes cell cycle arrest at G0/G1 phase.
- Reported activity across multiple cancer cell lines.
- High chemical purity (99.3%).
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Medchemexpress LLC Op-5244 sodium | 00-00-0 | 99.9% | C19H28ClN5NaO9P | 10MG
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OP-5244 sodium is the sodium salt of a potent, orally active small-molecule CD73 inhibitor that reverses immunosuppression by blocking adenosine production. Supplied for research use as a characterized solid with accompanying purity and analytical data.
- Potent CD73 inhibitor (IC50 0.25 nM).
- Reverses adenosine-mediated immunosuppression.
- High purity (99.9%).
- Chemical formula C19H28ClN5NaO9P; molecular weight 559.87 g·mol⁻¹.
- Available in small research quantities such as 10 mg.
- Solid form; store sealed at 4 °C.
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Medchemexpress LLC 4-((2-(hydroxymethyl)phenyl)amino)-2-((6-methoxy-2-methyl-thiq-7-yl)amino)pyrimidine-5-carboxamide | 2739844-28-9 | 99.4% | C23H26N6O3 | 10MG
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HPK1-IN-4 is a potent small-molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1/MAP4K1) used as a preclinical immunotherapy research tool. It exhibits subnanomolar activity against HPK1 (reported IC50 0.061 nM), is supplied as an off-white to light yellow solid, and is characterized by high purity and a defined chemical identity suitable for in vitro and early-stage in vivo studies.
- Potent HPK1 inhibition (IC50 0.061 nM).
- High chemical purity suitable for research applications.
- Well-characterized chemical identity and formula.
- Solid small-molecule form for formulation flexibility.
- Applicable as a preclinical tool to study HPK1-related signaling pathways.
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Medchemexpress LLC PD-1-IN-24 (compound 1) | 2360909-50-6 | 98.1% | C27H26F3NO3 | 10MG
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PD-1-IN-24 (compound 1) is a small-molecule, orally active PD-1 inhibitor used in preclinical immunology and oncology research. It modulates the PD-1/PD-L1 immune checkpoint pathway and has documented in vivo activity. The compound is provided as a powder or as DMSO solutions, and is supplied with analytical documentation including molecular formula C27H26F3NO3, molecular weight 469.50, and typical purity around 98.1%.
- Orally active small-molecule PD-1 inhibitor.
- Validated for PD-1/PD-L1 pathway modulation in preclinical models.
- Supplied as powder and ready-to-use DMSO solution formats.
- High supplied purity (~98.1%) for reproducible results.
- Available in multiple sizes suitable for screening and in vivo dosing.
- Accompanied by safety data sheet and technical datasheet documentation.
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Medchemexpress LLC AHR antagonist 5 | 2247953-39-3 | 98.1% | C25H27Cl3FN7 | 10MG
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AHR antagonist 5 is a potent, orally active aryl hydrocarbon receptor (AHR) antagonist intended for preclinical research. It demonstrates submicromolar in vitro potency and has shown in vivo activity reducing tumor growth when used with immune checkpoint inhibition. The material is supplied as a yellow-orange solid with defined solubility in DMSO and recommended cold storage conditions.
- Potent AHR antagonism with reported IC50 < 0.5 μM.
- Demonstrated in vivo efficacy in combination with anti-PD-1.
- High purity suitable for research applications.
- Soluble in DMSO at high concentrations; in vivo vehicle protocols available.
- Stable powder under recommended cold storage for long-term use.
- Available as solid and as DMSO stock solution formats.
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Medchemexpress LLC Lp-PLA2-IN-3 | 2196245-16-4 | 99.9% | C20H13ClF3N3O3S | 10MG
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Lp-PLA2-IN-3 is a potent, orally bioavailable small-molecule inhibitor of lipoprotein-associated phospholipase A2 used for biochemical and preclinical research. It exhibits an IC50 of 14 nM against recombinant human Lp-PLA2 and is supplied at high purity for assay and pharmacology applications.
- Potent inhibition: IC50 of 14 nM against recombinant human Lp-PLA2.
- Orally bioavailable small molecule suitable for in vivo studies.
- High purity (≈99.9%) for consistent experimental results.
- Provided in multiple quantities and solution formats for flexibility.
- Soluble in DMSO; recommended for preparing stock solutions.
- Appropriate for target validation, enzymology, and pharmacology studies.
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Medchemexpress LLC 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile | 3546-03-0 | MFCD00868180 | 99.4% | C19H21N3S | 10MG
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Cyamemazine is a phenothiazine-class neuroleptic used in research for its anxiolytic and antipsychotic properties. It functions as a serotonin receptor antagonist and is supplied as solid reference standards and DMSO solutions for pharmacology and biochemical assays. Chemical identifiers: CAS 3546-03-0; formula C19H21N3S; mol wt 323.46 g·mol⁻1.
- Phenothiazine-class neuroleptic with anxiolytic and antipsychotic activity.
- Antagonist at 5-HT3, 5-HT2A, and 5-HT2C receptors.
- Available as solid standards and 10 mM DMSO solution for assay preparation.
- High purity suitable for research use (99.4%).
- Includes RP-HPLC documentation for quality verification.
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Medchemexpress LLC Cbp/p300-in-8 | 2304416-91-7 | 99.9% | C27H31N3O4 | 10MG
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CBP/p300-IN-8 is a small-molecule inhibitor that targets the bromodomains of the CBP/p300 family and is used in epigenetic research. It inhibits CBP at low-nanomolar concentrations and exhibits activity against BRD4, and is supplied as a high-purity solid reagent for laboratory studies.
- Potent inhibitor of CBP/p300 bromodomains.
- CBP IC50 0.01-0.1 μM; BRD4 IC50 1-1000 μM.
- Molecular formula C27H31N3O4; molecular weight 461.55.
- High purity (99.94%).
- White to off-white solid for analytical and biological assays.
- Available in small research pack sizes with room-temperature shipping options.
- Storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent at -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl... | 2826996-78-3 | 98.0% | C25H21N5OS | 10MG
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HIV-1 inhibitor-8 is an orally active small-molecule non-nucleoside reverse transcriptase inhibitor (NNRTI) used in research to probe HIV-1 replication and reverse transcriptase function. It shows potent antiviral activity in cellular assays, low cytotoxicity, and demonstrated favorable pharmacokinetic properties in rodent studies. The compound is supplied as a light yellow to light brown solid with high analytical purity suitable for biochemical and cellular experiments.
- Potent antiviral activity (EC50 = 4.44-54.5 nM) against various HIV-1 strains.
- Inhibits wild-type HIV-1 reverse transcriptase (IC50 = 0.081 μM).
- Low cytotoxicity (CC50 = 284 μM) and high selectivity index.
- High purity and stable solid form for reliable experimental use.
- Good solubility in DMSO (50 mg/mL) for in vitro assays.
- Low hERG inhibition and favorable in vivo pharmacokinetic profile in rodents.
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Medchemexpress LLC SCHAFTOSIDE 98% 10MG
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Schaftoside 98% 10mg 51938-32-0
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eMolecules 60811-18-9 | 4-Bromo-1-chloro-2-fluorobenzene | Ambeed | MFCD00042519 | 209.44 | C6H3BrClF | 98 | Fc1cc(Br)ccc1Cl | 10g | 525019385
4-Bromo-1-chloro-2-fluorobenzene | Ambeed | 60811-18-9 | MFCD00042519 | 209.440 | C6H3BrClF | 98.000 | Fc1cc(Br)ccc1Cl | 10g | 525019385
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eMolecules 460-00-4 | 1-Bromo-4-fluorobenzene | Ambeed | MFCD00000342 | 175 | C6H4BrF | 95 | Fc1ccc(Br)cc1 | 10g | 518523234
Ambeed | 3-Bromo-5-chloropyrazolo[15-a]pyrimidine | 1g | 525199200 | A373429 | 960613-96-1 | MFCD11520857 | 232.470 | C6H3BrClN3
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Aurora Fine Chemicals 3-(3-FLUOROPHENYL)-1- 4-25MG
3-(3-fluorophenyl)-1-[4-[(6-imidazol-1-ylpyrimidin-4-yl)amino]phenyl]urea, 1360287-51-9
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