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Filtered Search Results
MEDCHEMEXPRESS LLC Nucc-390 dihydrochloride | 2749281-71-6 | MFCD32690075 | 98.2% | 468.46 g·mol⁻¹ | C23H35Cl2N5O | 5 MG
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NUCC-390 dihydrochloride is a small-molecule dihydrochloride salt that acts as a selective CXCR4 receptor agonist for research use. It induces CXCR4 internalization and has been reported to promote nerve recovery after neurodegeneration. The compound is supplied as a light yellow to yellow solid, with a molecular formula of C23H35Cl2N5O and a molecular weight of 468.46 g·mol⁻¹.
- Selective CXCR4 receptor agonist that induces receptor internalization.
- Reported to promote nerve recovery after neurodegeneration in vivo.
- High purity suitable for research applications (98.2%).
- Supplied as a solid; also available as a DMSO solution for convenience.
- Stable when stored as recommended (powder at 4°C; in solvent -80°C or -20°C under nitrogen).
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MEDCHEMEXPRESS LLC Egfr-in-5 | 2225887-26-1 | 99.5% | 571.69 g·mol-1 | C31H38FN9O | 5 MG
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EGFR-IN-5 is a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) that displays low-nanomolar potency against wild-type EGFR and clinically relevant resistant mutants. It is supplied for research use with confirmed high purity and documented solubility and storage conditions suitable for biochemical and cellular studies.
- Low-nanomolar inhibitory activity against EGFR and common resistant mutants (IC50: 10.4 nM for wild-type; 1.1 nM for L858R; 34 nM for L858R/T790M; 7.2 nM for L858R/T790M/C797S).
- High chemical purity suitable for research applications.
- Soluble in DMSO at ≥ 100 mg/mL; formulation data available for in vivo dosing.
- Stable as a powder at -20°C for long-term storage; solvent stability documented at -80°C (6 months) and -20°C (1 month).
- Appropriate for biochemical assays and preclinical cellular studies.
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MEDCHEMEXPRESS LLC Aurora kinase inhibitor II | 331770-21-9 | 99.1% | 400.43 g·mol⁻1 | C23H20N4O3 | 5 MG
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Aurora kinase inhibitor-2 is a selective, ATP-competitive small-molecule inhibitor of Aurora kinases A and B used in biochemical and cell-based research. It shows inhibitory activity in the low hundreds of nanomolar range and is supplied as a solid suitable for in vitro and in vivo formulation studies.
- Selective ATP-competitive inhibitor of Aurora A and Aurora B (IC50: Aurora A 310 nM; Aurora B 240 nM).
- Supplied as a white to yellow solid with high reported purity (~99.1%).
- Molecular formula C23H20N4O3 and molecular weight 400.43 g·mol⁻1.
- Dissolves readily in DMSO; recommended in vitro solubility 100 mg/mL (ultrasonic may be required).
- Formulatable for in vivo studies using common vehicles (SBE-β-CD, corn oil, PEG300/Tween-80 mixes).
- Intended for research applications probing Aurora kinase function and signaling.
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AMBEED 1-BROMO-2-CHLORO-4-FLUOROBENZE
NC3834418 1-BROMO-2-CHLORO-4-FLUOROBENZE
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MEDCHEMEXPRESS LLC Tezacaftor Vx-661 5Mg | HY-15448-5MG
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Tezacaftor Vx-661 5Mg
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MEDCHEMEXPRESS LLC 2-selenouracil | 16724-03-1 | 98.0% | 175.05 g·mol⁻¹ | C4H4N2OSe | 5 MG
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2-Selenouracil is a small-molecule photosensitizer used in photodynamic therapy research. It produces reactive oxygen species upon light activation and is supplied for laboratory research use only.
- Useful specialized photosensitizer for photodynamic therapy research.
- Generates reactive oxygen species (ROS) under light activation.
- Chemical formula C4H4N2OSe; molecular weight 175.05 g·mol⁻¹.
- High purity, typically 98.0% as supplied.
- Available in small laboratory quantities, such as 5 mg, for research applications.
- Accompanied by a product datasheet describing handling and specifications.
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MEDCHEMEXPRESS LLC 2-(3,4-dihydroquinolin-1(2H)-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide | 1031496-06-6 | MFCD00045972 | 99.9% | 347.41 g/mol | C21H21N3O2 | 5 MG
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CIM0216 is a potent, selective agonist of the TRPM3 ion channel used as a research tool to probe TRPM3-dependent cellular and neurophysiological responses, including neurogenic inflammation and sensory neuron signaling. It is supplied as a high-purity solid or as a 10 mM solution in DMSO for laboratory use.
- Potent TRPM3 agonist with selectivity over related TRP channels.
- Induces TRPM3-dependent pain responses and neuropeptide release in vitro.
- High purity (99.94%) suitable for biochemical and cellular assays.
- Available as solid and as a 10 mM solution in DMSO for convenience.
- Molecular weight 347.41 g/mol; formula C21H21N3O2.
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![MEDCHEMEXPRESS LLC 11H-indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime | 312538-03-7 | 99.4% | 341.32 g·mol⁻1 | C20H11N3O3 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000240908.png-250.jpg)
MEDCHEMEXPRESS LLC 11H-indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime | 312538-03-7 | 99.4% | 341.32 g·mol⁻1 | C20H11N3O3 | 100 MG
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IQ-3 is a small-molecule inhibitor of the c-Jun N-terminal kinase (JNK) family with preference for JNK3. It binds JNK1, JNK2, and JNK3 with reported Kd values of 0.24 μM, 0.29 μM, and 0.066 μM, respectively. Supplied as an off-white to light yellow solid, IQ-3 is used in research to probe JNK signaling in vitro and in vivo; solubility, purity, and storage recommendations are provided on the product datasheet.
- Preference for JNK3 over JNK1 and JNK2.
- Low-micromolar to sub-micromolar binding affinities for JNK isoforms.
- High purity (99.4%).
- Available as a solid and in DMSO solution for convenient dosing.
- Soluble in DMSO (25 mg/mL); sonication recommended.
- Powder storage at -20°C with defined solvent stability.
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MEDCHEMEXPRESS LLC Ensartinib dihydroch 100mg | 2137030-98-7 | 100MG
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Ensartinib dihydrochloride (X-396 dihydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of 0 4 nM and 0 74 nM respectively
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MEDCHEMEXPRESS LLC Dxd 10 Mm 1 Ml In Dmso | HY-13631D
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Dxd 10 Mm 1 Ml In Dmso
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MEDCHEMEXPRESS LLC IK-175 (AHR antagonist 5 free base) | 2247950-42-9 | 99.8% | C25H24FN7 | 10MG
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IK-175 is an orally active, selective small-molecule antagonist of the aryl hydrocarbon receptor (AHR) developed for oncology research and clinical investigation. It modulates the tumor microenvironment and has shown target engagement and preliminary antitumor activity in early clinical studies. Supplied as a white to off-white solid for research use only.
- Selective antagonist of the aryl hydrocarbon receptor (AHR).
- Orally bioavailable candidate suitable for in vivo studies.
- Modulates the tumor microenvironment to enhance immune response.
- High supplied purity (≈99.8%).
- White to off-white solid physical form.
- High solubility in DMSO for in vitro assays.
- Powder storage recommended at low temperatures to preserve stability.
- For research use only; not for human or clinical use outside controlled studies.
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![MEDCHEMEXPRESS LLC 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile | 3546-03-0 | MFCD00868180 | 99.4% | C19H21N3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260854.png-250.jpg)
MEDCHEMEXPRESS LLC 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile | 3546-03-0 | MFCD00868180 | 99.4% | C19H21N3S | 10MG
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Cyamemazine is a phenothiazine-class neuroleptic used in research for its anxiolytic and antipsychotic properties. It functions as a serotonin receptor antagonist and is supplied as solid reference standards and DMSO solutions for pharmacology and biochemical assays. Chemical identifiers: CAS 3546-03-0; formula C19H21N3S; mol wt 323.46 g·mol⁻1.
- Phenothiazine-class neuroleptic with anxiolytic and antipsychotic activity.
- Antagonist at 5-HT3, 5-HT2A, and 5-HT2C receptors.
- Available as solid standards and 10 mM DMSO solution for assay preparation.
- High purity suitable for research use (99.4%).
- Includes RP-HPLC documentation for quality verification.
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MEDCHEMEXPRESS LLC Ezetimibe ketone | 191330-56-0 | MFCD13185925 | 100.0% | 407.41 g/mol | C24H19F2NO3 | 5 MG
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Ezetimibe ketone is a phase-I metabolite of ezetimibe that functions as an inhibitor of NPC1L1 and is used in research to study cholesterol absorption and metabolism. It is provided as a high-purity reference material for in vitro and analytical applications and is not for human use.
- Phase-I metabolite of ezetimibe.
- NPC1L1 inhibitor that reduces intestinal cholesterol absorption.
- Reported purity 99.97%.
- Molecular formula C24H19F2NO3.
- Molecular weight 407.41 g/mol.
- Supplied in small research quantities, such as 5 mg.
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MEDCHEMEXPRESS LLC RORγt inverse agonist 13 | 2170477-75-3 | 98.1% | 513.29 | C23H17Cl2F3N2O4 | 5 MG
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RORγt inverse agonist 13 (Compound 3i) is a potent, orally active, and selective inverse agonist of the RORγt nuclear receptor with a reported IC50 of 63.8 nM. The compound is supplied for research use and is available as solid and solution formulations with high analytical purity.
- Potent inverse agonist of RORγt with IC50 of 63.8 nM.
- Orally active and selective for RORγt.
- High purity (98.1%) suitable for research applications.
- Molecular weight 513.29; formula C23H17Cl2F3N2O4.
- Available as solid (5-500 mg) and as DMSO solutions for convenient dosing.
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MEDCHEMEXPRESS LLC CCR2 antagonist 4 hydrochloride | 1313730-14-1 | MFCD16618399 | 99.9% | 476.32 g/mol | C21H22Cl2F3N3O2 | 10 MG
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CCR2 antagonist 4 hydrochloride is a research-grade small-molecule antagonist of the CC chemokine receptor 2 (CCR2), supplied as the hydrochloride salt for laboratory research use. It is used as a tool compound in studies of inflammation and chemotaxis. CAS 1313730-14-1; molecular formula C21H22Cl2F3N3O2; molecular weight 476.32 g/mol.
- High purity suitable for research applications.
- Provided as the hydrochloride salt for improved handling and stability.
- Intended for in vitro research and chemotaxis studies.
- Supplied in a 10 mg package.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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