Fluorobenzenes
Medchemexpress LLC Glycyl-exatecan-d5 (hydrochloride) | 00-00-0 | 99.0% | 533.99 g·mol⁻1 | C26H21D5ClFN4O5 | 5 MG
Glycyl-Exatecan-d5 hydrochloride is a deuterium-labeled derivative of exatecan used as a research reagent in oncology. It functions as an isotopically labeled reference for studies of topoisomerase-targeting anticancer agents, antibody-drug conjugate payload research, and analytical assays such as mass spectrometry.
- Deuterium-labeled for tracer and mass spectrometry applications.
- Used in topoisomerase inhibitor research and ADC development.
- High purity suitable for analytical and preclinical studies.
- Available in milligram quantities for research workflows.
Medchemexpress LLC Canagliflozin-d4 1mg | 1997338-61-0 | 1MG
Canagliflozin-d4 (JNJ 28431754-d4) is a deuterium labeled Canagliflozin Canagliflozin is a selective SGLT2 inhibitor[1
Medchemexpress LLC Sertindole-d4 | 1794737-42-0 | 98.6% | C24H22D4ClFN4O | 1 MG
Sertindole-d4 is a deuterium-labeled form of Sertindole, a well-known neuroleptic medication. This compound is primarily used in research applications, offering stable isotopic labeling for various analytical techniques. It is particularly valuable as a tracer for quantitation during drug development and can serve as an internal standard for precise quantitative analysis using methods like NMR, GC-MS, or LC-MS. Deuterium substitution can also influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium-labeled compound for research.
- Acts as a tracer in drug development processes.
- Suitable as an internal standard for quantitative analysis.
- Potential for studying pharmacokinetic and metabolic profiles.
- Useful in NMR, GC-MS, and LC-MS applications.
Medchemexpress LLC Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-(methyl-d3)- | 1443331-82-5 | >99.8% | C21H13D3F4N4O2S | 5 MG
Deutenzalutamide-d3 (Enzalutamide-d3) is a deuterium-labeled variant of Enzalutamide. Enzalutamide is recognized as an androgen receptor (AR) antagonist, demonstrating an IC50 of 36 nM in LNCaP prostate cells. This compound is primarily used for research purposes.
- Deuterium-labeled compound for research applications
- Potent androgen receptor antagonist
- IC50 of 36 nM in LNCaP prostate cells
- High purity with >99.8% by LCMS
Medchemexpress LLC Glycyl-Exatecan-d5 hydrochloride | 1883333-57-0 | 99.0% | 1 MG
Glycyl-Exatecan-d5 hydrochloride is a deuterium-labeled derivative of Glycyl-Exatecan, which is itself a derivative of Exatecan. This compound functions as an anticancer agent, demonstrating significant antitumor activity. It is suitable for research related to various cancers, including solid tumors. It also serves as a tracer and an internal standard for quantitative analytical methods such as NMR, GC-MS, or LC-MS.
- Deuterium labeled compound
- Derivative of Exatecan
- Anticancer agent with significant antitumor activity
- Suitable for solid tumors research
- Functions as a tracer
- Used as an internal standard for quantitative analysis
Medchemexpress LLC Dxd-d5 (exatecan-d5 derivative for ADC) | 00-00-0 | 98.9% | C26H19D5FN3O6 | 10MG
Dxd-d5 is a deuterium-labeled form of DXd, an exatecan-derived ADC payload and potent DNA topoisomerase I inhibitor. DXd has a reported IC50 of 0.31 μM and is used as the cytotoxic component in HER2-targeting antibody-drug conjugates. Dxd-d5 is provided for research use as a tracer and as an internal standard for quantitative analytical methods and ADC development studies.
- Deuterium-labeled tracer suitable for metabolic and mechanistic studies.
- Potent topoisomerase I inhibitor with reported IC50 0.31 μM.
- Suitable as an internal standard for NMR, GC-MS, and LC-MS quantitation.
- High reported purity appropriate for analytical applications.
- Molecular formula C26H19D5FN3O6 and molecular weight 498.51.
- Provided in small-scale quantities for analytical and research workflows.
Biotium DIOC14(3)
DiOC14(3) is a DiO derivative, but is more soluble in aqueous media than the latter because it has shorter hydrocarbon chains. Also offered as ready-to-use CellBrite™ Cell Membrane Labeling Solutions. Properties: Ex/ Em(MeOH) = 484/501nm; e (MeOH) = 150,000; Orange solid soluble in methanol, ethanol or DMSO; Store desiccated at 4°C; C47H74N2O6S; MW: 795
Medchemexpress LLC HY-B1684 10mg Medchemexpress, Mebrofenin CAS:78266-06-5 Purity:>98%
Medchemexpress, HY-B1684 10mg Mebrofenin CAS:78266-06-5 Mebrofenin (SQ 26962) is a type of iminodiacetic acid (IDA). Mebrofenin is available as a ready to use the kit for radio-labeling with Tc-99m. Tc-99m Mebrofenin, a diagnostic agent, is used for hepatobiliary imaging. Tc-99m Mebrofenin is the radiopharmaceutical of choice for the evaluation of hepatic function. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Florbetapir (18F)-radiolabeled styrylpyridine tosylate precursor | 1205550-99-7 | 99.7% | 100 MG
A styrylpyridine tosylate precursor used to synthesize 18F-radiolabeled florbetapir-type tracers for positron emission tomography (PET) research.
- High chemical purity suitable for radiolabeling workflows.
- Used to synthesize 18F-labeled PET imaging agents targeting amyloid plaques.
- White to yellow solid; easy handling and storage as a dry powder.
- Long-term stability when stored at -20°C; solvent solutions require colder storage.
- Available in small research-scale quantities for tracer development.
Medchemexpress LLC Abemaciclib-d8 | 2088650-53-5 | 99.96% | 514.64 | 5 MG
Abemaciclib-d8 is the deuterium labeled Abemaciclib. Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Abemaciclib-d8 | 2088650-53-5 | 99.9% | 514.64 | 1 MG
Abemaciclib-d8 is the deuterium labeled Abemaciclib. Abemaciclib is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively. Stable heavy isotopes have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Sitagliptin-d4 phosphate | 1432063-88-1 | 99.5% | 509.33 | 1 MG
Sitagliptin-d4 phosphate (MK-0431-d4) is the deuterium-labeled Sitagliptin phosphate. It is an orally active, highly selective DPP4 inhibitor with an IC50 value of 19 nM. It blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), which increases active incretin levels. It can also directly stimulate GLP-1 secretion by intestinal L cells, independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models and can be used for the study of 1-type and 2-type diabetes.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Ars-1323-alkyne | 2436544-27-1 | MFCD32067946 | 99.6% | 569.00 g/mol | C28H27ClF2N6O3 | 5 MG
ARS-1323-alkyne is a covalent inhibitor probe that selectively targets the Switch-II pocket (S-IIP) of KRAS G12C. It is used to visualize covalent modification and to quantify inhibitor binding and target occupancy in biochemical and cellular studies; for research use only.
- Covalent binding to the KRAS G12C Switch-II pocket.
- Alkyne handle enables click-chemistry labeling and detection.
- High purity (99.6%) suitable for biochemical and cellular assays.
- Soluble in DMSO (250 mg/mL) and formulatable for in vivo dosing protocols.
- Recommended storage: solid at 4°C under nitrogen; store solutions frozen for stability.
- Molecular formula C28H27ClF2N6O3; molecular weight 569.00 g/mol.
Medchemexpress LLC Deutenzalutamide (enzalutamide-d3) | 1443331-82-5 | 99.8% | C21H13D3F4N4O2S | 1 MG
Deutenzalutamide (Enzalutamide-d3) is a deuterium-labeled form of Enzalutamide, an androgen receptor (AR) antagonist. It serves as a tracer and internal standard for quantitative analysis methods including NMR, GC-MS, or LC-MS. Deuterated compounds offer advantages such as extending in vivo half-life, improving oral bioavailability, and enhancing metabolic characteristics for drug safety.
- Androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells
- Functions as a tracer for quantitative analysis
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may extend in vivo half-life, improve oral bioavailability, and enhance metabolic characteristics
- Potential to improve drug safety while retaining therapeutic properties
- Utilized in cancer, cancer targeted therapy, and cancer metabolism research