Phenylpropenes
Medchemexpress LLC Interferon alpha-4, recombinant (mouse) | >95.0% | 50 UG
Recombinant mouse interferon alpha-4 produced in HEK293 cells with a C-terminal His tag. Supplied as a 50 μg vial of 0.22 μm filtered PBS (pH 7.4), purified and characterized by SDS-PAGE and COA; intended for research use in cell signaling and antiviral response assays. Store at -80°C and avoid repeated freeze-thaw cycles.
- Expressed in HEK293 cells.
- C-terminal His tag facilitates detection and purification.
- Purity greater than 95% by reducing SDS-PAGE.
- Formulated in PBS, pH 7.4, and 0.22 μm filtered.
- Endotoxin level <1 EU/μg.
- Observed molecular weight ~22-27 kDa due to glycosylation.
- Store at -80°C for long-term stability; avoid repeated freeze-thaw cycles.
Medchemexpress LLC Interferon alpha-4 recombinant (mouse) | 96.5% | 5 UG
Recombinant mouse interferon alpha-4 is a type I interferon with antiviral activity provided as a research-grade protein expressed in HEK293 mammalian cells and carrying a C-terminal His tag for purification and detection. The protein comprises amino acids C25-E186 (162 aa) and is supplied as a small, high-purity aliquot suitable for in vitro studies.
- Recombinant protein expressed in HEK293 cells.
- C-terminal His tag for purification and detection.
- Contains 162 amino acids (C25-E186).
- High purity (96.5%) suitable for research applications.
- Supplied as a 5 μg research aliquot for in vitro use.
Medchemexpress LLC Interferon alpha-4 (mouse), recombinant (HEK293, His-tagged) | >95.0% | 20 UG
Recombinant mouse interferon alpha-4 produced in HEK293 cells with a C-terminal His tag. This purified cytokine (162 amino acids, C25-E186; UniProt P07351) is intended for research applications requiring biologically active IFN-α4. Purity is >95% by reducing SDS-PAGE. Store at -80°C for long-term storage and avoid repeated freeze-thaw cycles.
- Recombinant mouse interferon alpha-4 produced in HEK293 cells.
- C-terminal His tag for detection and purification.
- 162 amino acids (C25-E186); UniProt P07351.
- Purity greater than 95% by reducing SDS-PAGE.
- Store at -80°C for long-term; avoid repeated freeze-thaw cycles.
Medchemexpress LLC Madecassic acid (Standard) | 18449-41-7 | 504.70 | 50 MG
Madecassic acid (Standard) is an analytical standard intended for research and analytical applications. It is isolated from *Centella asiatica* and possesses anti-inflammatory properties through the inhibition of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 via downregulation of NF-κB activation in RAW 264.7 macrophage cells. This compound serves as a reference standard, commonly used in qualitative, quantitative, and methodological research experiments involving HPLC, GC, and MS.
- Analytical standard for research and analytical applications.
- Isolated from *Centella asiatica*.
- Exhibits anti-inflammatory properties.
- Inhibits iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6.
- Downregulates NF-κB activation in macrophage cells.
- Used in HPLC, GC, and MS research.
Medchemexpress LLC Tolfenamic acid (standard) | 13710-19-5 | 50 MG
Tolfenamic Acid (Standard) is primarily used for research and analytical applications. It acts as a non-steroidal anti-inflammatory and anti-cancer agent.
- Selectively inhibits COX-2, with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells
- Shows no effect on COX-1
- Intended for research and analytical use
Medchemexpress LLC Interferon alpha-4 (mouse) recombinant protein (HEK293, C-terminal His-tag) | >95.0% | 10 UG
Recombinant mouse interferon alpha-4 (IFN-α4) produced in HEK293 cells with a C-terminal His tag. Supplied as a 0.22 μm filtered PBS solution for research use; the construct corresponds to residues C25-E186, with predicted mass 20.2 kDa and purity >95% by reducing SDS-PAGE. Intended for studies of type I interferon signaling and antiviral responses.
- Produced in HEK293 cells with a C-terminal His tag.
- Corresponds to residues C25-E186 of the native protein.
- Predicted molecular mass 20.2 kDa; appears ~22-27 kDa on SDS-PAGE due to glycosylation.
- Purity >95.0% as determined by reducing SDS-PAGE.
- Supplied as 0.22 μm filtered in PBS, pH 7.4.
- Provided for research use only, not for therapeutic or diagnostic use.
- Suitable for studies of interferon signaling and antiviral activity.
Medchemexpress LLC Madecassic acid (Standard) | 18449-41-7 | 504.70 | 5 MG
Madecassic acid (Standard) is the analytical standard of Madecassic acid, intended for research and analytical applications. It is isolated from *Centella asiatica* (Umbelliferae) and exhibits anti-inflammatory properties through the downregulation of NF-κB activation in RAW 264.7 macrophage cells.
- Used as a reference standard supplied assay
- Commonly used in qualitative, quantitative and methodological research experiments
- Suitable for HPLC, GC and MS applications
Medchemexpress LLC Tolfenamic acid | 13710-19-5 | 99.8% | 25 MG
Tolfenamic acid is the analytical standard of Tolfenamic acid. It is a non-steroidal anti-inflammatory and anti-cancer agent that selectively inhibits COX-2, with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, but shows no effect on COX-1. This product is intended for research and analytical applications.
- Analytical standard of Tolfenamic acid
- Intended for research and analytical applications
- Non-steroidal anti-inflammatory and anti-cancer agent
- Selectively inhibits COX-2
Apexbio Technology LLC Ganetespib (STA-9090)(Synonyms: STA-9090, Ganetespib, STA9090, STA 9090), 10mM (in 1mL DMSO), CAS: 888216-25-9.
Ganetespib (STA-9090 CAS 888216-25-9) is a small-molecule inhibitor targeting heat shock protein 90 (Hsp90) It binds competitively to the ATP-binding pocket located at the N-terminal region of Hsp90 disrupting its chaperone activity and subsequently causing degradation of client proteins involved in tumor growth and survival Structurally distinct from geldanamycin-derived inhibitors Ganetespib features a triazolone moiety Preclinical studies have demonstrated antitumor activity across various cancer cell types including lung prostate colon breast cancers melanoma and leukemia highlighting its therapeutic potential for cancer research
Apexbio Technology LLC STA-21 111540-00-2 1mg
STA-21 (CAS 111540-00-2) is a small-molecule inhibitor targeting STAT3 a transcription factor activated by cytokines such as IL-6 It inhibits STAT3 DNA-binding activity and dimerization thereby modulating downstream signaling pathways associated with Th17 differentiation and inflammatory processes STA-21 exerts its biological activity primarily by suppressing STAT3-mediated IL-17 expression and osteoclast differentiation as well as promoting FoxP3 expression In in vitro studies STA-21 inhibits DU145 cell viability with an IC50 of 12 2 M Based on these pharmacological properties STA-21 holds research potential in the fields of autoimmune and inflammatory disease
Medchemexpress LLC Madecassic acid (Standard) | 18449-41-7 | 504.70 | 25 MG
Madecassic acid is an analytical and reference standard isolated from Centella asiatica (Umbelliferae). It is intended for research and analytical applications, and exhibits anti-inflammatory properties by inhibiting iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 through the downregulation of NF-κB activation in RAW 264.7 macrophage cells.
- Analytical and reference standard
- Isolated from Centella asiatica (Umbelliferae)
- Exhibits anti-inflammatory properties by inhibiting iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6
- Used in qualitative, quantitative, and methodological research experiments
- Applications include HPLC, GC, and MS
Medchemexpress LLC Fenofibric acid | 42017-89-0 | 99.9% | 500 MG
Fenofibric acid is an active metabolite of fenofibrate and a PPAR activator, showing EC50s of 22.4 μM for PPARα, 1.47 μM for PPARγ, and 1.06 μM for PPARδ. It also inhibits COX-2 enzyme activity with an IC50 of 48 nM. This product is for research use only.
- Potently activates PPARα, PPARγ, and PPARδ
- Inhibits COX-2 enzyme activity
- Shows anti-inflammatory activity in Wistar rats
- Reduces abundance of AOX1 protein in HepG2 cells
- Decreases JNK1/2, c-Jun, and p38 MAPK phosphorylation
- Prevents accumulation of reactive oxygen species, ER stress, and disruption of the blood retinal barrier
- Activates IGF-IR/Akt/ERK1/2-mediated survival signaling pathways
- High purity of 99.94%
- Available in various forms: solid and solution in DMSO