Aminophenols
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Medchemexpress LLC Bi-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 1 ML
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting high selectivity over NHE2 and no measurable activity against NHE3. This compound shows low agent-agent interaction potential, excellent pharmacokinetics, and potent activity in isolated heart models of ischemia-reperfusion injury. It is intended for research use only.
- Decreases autophagy in HTR-8/SVneo cells.
- Significantly reduces the pHi of human sperm and partially reverses the effect of DMA.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Shows low DDI potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart models of ischemia-reperfusion injury.
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Medchemexpress LLC Rhosin (hydrochloride) | 1281870-42-5 | 99.9% | 394.86 | 25 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction without interacting with Cdc42, Rac1, or the GEF, LARG. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific inhibitor of the RhoA subfamily of Rho GTPases.
- Specifically binds to RhoA, inhibiting RhoA-GEF interaction.
- Induces cell apoptosis.
- Promotes stress resiliency.
- Reduces RhoA and p-MLC1 activities.
- Prevents social avoidance and blocks sucrose preference deficits.
- Attenuates stress-induced social avoidance and hyperexcitability.
- Enhances spine density in defeat mice.
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