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Filtered Search Results
Medchemexpress LLC Valnivudine hydrochloride | 956483-03-7 | 99.0% | 534.04 | 25 MG
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Valnivudine hydrochloride (FV-100) is a potent, selective, and orally active anti-varicella zoster virus agent. It is a proagent of CF-1743 and exhibits very low toxicity in vivo. It is intensely fluorescent when illuminated by wavelengths of 340-380 nm and produces a different distribution in HeLa cells within 1 hour. In rats, Valnivudine hydrochloride (50-500 mg/kg; p.o.) does not induce biologically relevant respiratory changes or any apparent neuropharmacological effects.
- Potent, selective, and orally active anti-varicella zoster virus agent
- Proagent of CF-1743
- Exhibits very low toxicity in vivo
- Intensely fluorescent when illuminated by wavelengths of 340-380 nm
- Produces a different distribution in HeLa cells within 1 hour
- Does not induce biologically relevant respiratory changes or apparent neuropharmacological effects in rats
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Medchemexpress LLC Gsk 3008348 hydrochloride | 1629249-40-6 | 99.9% | 25 MG
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GSK 3008348 hydrochloride is a small molecule antagonist of integrin αvβ6. It inhibits TGF-β activation, alleviating the fibrotic process, and prevents foot-and-mouth disease virus entry by targeting the αvβ6 integrin receptor. This compound is used in research for pulmonary fibrosis and various types of cancer.
- Antagonizes integrin αvβ6
- Inhibits TGF-β activation
- Alleviates the fibrotic process
- Prevents foot-and-mouth disease virus binding to the αvβ6 integrin receptor
- Supports research on pulmonary fibrosis
- Supports research on various types of cancer
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Medchemexpress LLC Hydralazine hydrochloride | 304-20-1 | 99.9% | 196.64 | 100 MG
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Hydralazine hydrochloride is an antihypertensive agent that can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. It also exhibits immunomodulation and anti-migratory effects, activating the intrinsic pathway of apoptosis and inducing DNA damage.
- Antihypertensive agent
- Inhibits mitochondrial fission
- Inhibits human peritoneal mesothelial cell proliferation
- Possesses immunomodulation effects
- Exhibits anti-migratory effects
- Activates the intrinsic pathway of apoptosis
- Causes DNA damage
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Medchemexpress LLC Asimadoline hydrochloride | 185951-07-9 | 99.6% | 451.00 | 5 MG
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Asimadoline hydrochloride is an orally active, selective, and peripherally active κ-opioid agonist. It demonstrates low permeability across the blood-brain barrier and exhibits peripheral anti-inflammatory actions. Research indicates its potential for treating irritable bowel syndrome (IBS) and ameliorating allodynia in diabetic rats.
- Orally active and selective κ-opioid agonist
- Low permeability across the blood-brain barrier
- Exhibits peripheral anti-inflammatory actions
- Potential for irritable bowel syndrome treatment
- Ameliorates allodynia in diabetic rats
- Rapid metabolism across species
- Highly selective for κ-opioid receptors
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Medchemexpress LLC Seltorexant (hydrochloride) | 1293284-49-7 | 99.9% | 443.91 | 5 MG
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Seltorexant hydrochloride is an orally active, high-affinity, and selective OX2R antagonist. It has pKi values of 8.0 and 8.1 for human and rat OX2R, respectively. This compound crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. It is intended for research use only.
- Orally active, high-affinity, and selective OX2R antagonist
- pKi values of 8.0 for human OX2R and 8.1 for rat OX2R
- Crosses the blood-brain barrier
- Quickly occupies OX2R binding sites in the rat brain
- For research use only
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Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | 99.6% | C21H28ClN5 | 100 MG
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Mavorixafor hydrochloride (AMD-070) is a potent, selective, and orally available CXCR4 antagonist with an IC50 value of 13 nM against CXCR4 125I-SDF binding. It also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 values of 1 nM and 9 nM, respectively. This compound can be used for the study of WHIM syndrome.
- Potent and selective CXCR4 antagonist.
- Orally available.
- Inhibits replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
- Used for the study of WHIM syndrome.
- Shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2).
- Significantly suppresses anchorage-dependent growth of B88-SDF-1 cells.
- Impairs motility and inhibits migration and Matrigel invasion of B88-SDF-1 cells.
- Inhibits lung metastasis of B88 SDF 1 cells in nude mice.
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Medchemexpress LLC Ondansetron hydrochloride | 99614-01-4 | MFCD00764297 | 99.4% | C18H20ClN3O | 100 MG
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Ondansetron hydrochloride (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist. It exerts its antiemetic effect by antagonizing 5-HT receptors in the peripheral and central nervous systems, inhibiting nausea and vomiting induced by chemotherapy and radiotherapy.
- Highly selective 5-HT3 receptor antagonist (IC50: 103 pM)
- Exerts antiemetic effect
- Inhibits nausea and vomiting from chemotherapy and radiotherapy
- Reduces EAAT3 response to L-glutamate (IC50: 8.57 μM)
- Exhibits anti-inflammatory effects through 5-HT3 receptor
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Medchemexpress LLC Ifebemtinib hydroch 10mg | 10MG
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Ifebemtinib hydroch 10mg | 10MG
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Medchemexpress LLC Cyclobenzaprine (hydrochloride) | 6202-23-9 | 99.9% | 25 MG
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Cyclobenzaprine hydrochloride is an orally active 5-HT2 receptor antagonist that centrally provides skeletal muscle relaxation, alleviates muscle spasms, and reduces pain. It also possesses antiparasitic activity, showing promise for research in acute, painful skeletal muscle disorders and infectious diseases.
- Orally active 5-HT2 receptor antagonist
- Provides skeletal muscle relaxation and alleviates muscle spasms
- Reduces pain
- Exhibits antiparasitic activity
- Active against Leishmania infantum promastigotes and intracellular amastigotes
- Induces oxidative stress in Leishmania infantum
- Suppresses quadriceps activity in ischemic spinal cord rigidity models
- Prevents tonic-extensor seizures
- Reduces parasite load in Leishmania infantum-infected mice
- Blocks α-motoneuronal excitation
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Medchemexpress LLC Epetraborole hydrochloride | 1234563-16-6 | MFCD28411360 | 99.6% | 273.52 g/mol | C11H17BClNO4 | 100MG
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Epetraborole hydrochloride is a research-grade leucyl-tRNA synthetase (LeuRS) inhibitor supplied as a hydrochloride salt for antibacterial research. It inhibits protein synthesis (reported IC50 = 0.31 μM) and is used in studies of multidrug-resistant gram-negative pathogens. Supplied as a high-purity solid, it requires sealed storage at 4°C and long-term storage in solution at -80°C.
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Medchemexpress LLC Benzetimide hydrochloride | 5633-14-7 | 99.4% | 1 ML
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Benzetimide hydrochloride is a muscarinic acetylcholine receptor (mAChR) antagonist, also identified as R4929 and Dioxatrine. This product is intended for research use only and is not for human use.
- Acts as a muscarinic acetylcholine receptor (mAChR) antagonist.
- Suitable for various research applications including neurological, eye or ear, neurodegenerative diseases, and Parkinson's disease.
- Useful in GPCR/G Protein, neuronal signaling, and mAChR studies.
- High purity of 99.44%.
- Molecular weight of 398.93.
- Appearance: solid, white to off-white.
- Soluble in DMSO and water.
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Medchemexpress LLC Dexmedetomidine hydrochloride | 145108-58-3 | 99.9% | 236.74 | 25 MG
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Dexmedetomidine hydrochloride is a potent, selective, and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. It exhibits anxiolysis, sedation, and modest analgesia effects. This product is an analytical standard intended for research and analytical applications.
- Potent, selective, and orally active agonist of α2-adrenoceptor
- Shows 1620-fold selectivity against α1-adrenoceptor
- Exhibits anxiolysis, sedation, and modest analgesia effects
- Intended for research and analytical applications
- Analytical standard
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Medchemexpress LLC Ractopamine hydrochloride | 90274-24-1 | 99.2% | 50 MG
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Ractopamine hydrochloride, also known as LY031537, is a potent β-adrenergic receptor (βAR) agonist with a Kd value of approximately 25 nM for pig β1AR and β2AR. It is associated with protein metabolism and is used in research to promote lean tissue growth and enhance production efficiency in pigs.
- Potent β-adrenergic receptor (βAR) agonist
- Impacts protein metabolism
- Research application in lean tissue growth
- Improved production efficiency in pigs
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Medchemexpress LLC Minocycline (hydrochloride) | 13614-98-7 | 99.1% | 493.94 | 1 G
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Minocycline (hydrochloride) | 13614-98-7 | 99.1% | 493.94 | 1 G
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Medchemexpress LLC Bomedemstat hydrochloride | 99.9% | 556.07 | 100 MG
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Bomedemstat hydrochloride | 99.9% | 556.07 | 100 MG
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