Oxazoles
FUJIFILM BIOSCIENCES INC CultureSure Y-27632
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It enhances cell viability and reduces cell death during passaging and cryopreservation Y-27632 is selective and potent ROCK inhibitor Y-27632 plays various roles including contraction of vascular smooth muscle cells via ROCK signaling pathways Furthermore it suppresses the cell death of human embryonic stem cells hESCs and human induced Pluripotent Stem Cells hiPSCs at cell dispersion and that it increases the survival rate of hESCs and hiPSCs during cryopreservation
FUJIFILM BIOSCIENCES INC CultureSure Y-27632
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It enhances cell viability and reduces cell death during passaging and cryopreservation Y-27632 is selective and potent ROCK inhibitor Y-27632 plays various roles including contraction of vascular smooth muscle cells via ROCK signaling pathways Furthermore it suppresses the cell death of human embryonic stem cells hESCs and human induced Pluripotent Stem Cells hiPSCs at cell dispersion and that it increases the survival rate of hESCs and hiPSCs during cryopreservation
FUJIFILM BIOSCIENCES INC CultureSure Y-27632
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture Y-27632 is selective and potent ROCK inhibitor Y-27632 plays various roles including contraction of vascular smooth muscle cells via ROCK signaling pathways Furthermore it suppresses the cell death of human embryonic stem cells hESCs and human induced Pluripotent Stem Cells hiPSCs at cell dispersion and that it increases the survival rate of hESCs and hiPSCs during cryopreservation
FUJIFILM BIOSCIENCES INC CultureSure 10mmol/L Y-27632
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It enhances cell viability and reduces cell death during passaging and cryopreservation Y-27632 inhibits contraction of the vascular smooth muscle infiltration of cancer cells and regulation of cell differentiation caused by a signal transduction system of ROCK Enhances survival rate after cryopreservation and cloning efficiency of human ES and iPS cells This product is Y-27632 prepared in water at 10 mmol/l and sterile-filtered No animal-derived matters are used in the process of manufacturing
FUJIFILM BIOSCIENCES INC Y-27632 GMP-compliant
Y-27632 is reagent for cell culture applications including human ES/iPS cell culture It enhances cell viability and reduces cell death during passaging and cryopreservation It is a selective and potent inhibitor of ROCK Rho-associated coiled-coil forming kinase/Rho binding kinase Y-27632 has a variety of activities including vascular smooth muscle contraction through the ROCK signaling Ki 140 nmol/L p160ROCK This product has been reported to suppress death of human ES/iPS cells at the time of cell dispersion and improves viability of the cells after cryopreservation This product complies with ICH-Q7 GMP for APIs as a raw material for commercial production of regenerative medicine products
Medchemexpress LLC TCS 2510 | 346673-06-1 | 98.3% | 383.49 | 10 MG
TCS 2510 is a selective EP4 agonist. It is used for the research of metabolic diseases.
- Stimulates glucagon like peptide 1 secretion.
- Activates the Gas signaling pathway.
- Increases Gcg mRNA expression levels in GLUTag cells.
- Produces a concentration dependent increase in cAMP levels in GLUTag cells.
- Decreases cell impedance in GLUTag cells in a concentration dependent manner.
- Produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells.
- Elevates plasma glucagon like peptide 1 levels in fasted mice.
- Increases plasma glucagon like peptide 2 levels.
Medchemexpress LLC Lewis y tetrasaccharide | 82993-43-9 | 675.63 | 1 MG
Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative of Lewis X trisaccharide. It is an antigen associated with malignant ovarian carcinoma metastasis and poor prognosis. In vitro studies indicate its role in activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression, thereby enhancing cell adhesion-mediated drug resistance (CAM-DR) in ovarian cancer cells. It also leads to an increase in integrin α5β1 levels in ovarian carcinoma-derived cells that exhibit enhanced expression of LeY.
- Enhances the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells, mediated by integrin-fibronectin interaction.
- Anti-LeY antibodies significantly inhibit the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo.
Medchemexpress LLC Y-27632 dihydrochloride | 129830-38-2 | 99.9% | 320.26 g/mol | C14H23Cl2N3O | 10 MG
Y-27632 dihydrochloride is an ATP-competitive inhibitor of Rho-associated kinases (ROCK1 and ROCK2) used in research to modulate Rho/ROCK signaling, cytoskeletal dynamics, and cell migration. It is cell permeable, has reported oral activity in models, and has demonstrated antiepileptic effects in studies.
- ATP-competitive inhibition of ROCK1 and ROCK2 (reported Ki ≈ 220-300 nM).
- Cell-permeable small molecule for in vitro and in vivo studies.
- High reported chemical purity suitable for research use.
- Available in milligram to gram pack sizes and as DMSO solutions for assay preparation.
- Useful for studies of cytoskeletal regulation, cell migration, and related signaling pathways.
- Includes CAS and molecular formula identifiers for traceability.
Medchemexpress LLC Y-27632 dihydrochloride | 129830-38-2 | MFCD03490488 | 99.9% | 320.26 g/mol | C14H23Cl2N3O | 50 MG
Y-27632 dihydrochloride is an ATP-competitive inhibitor of Rho-associated protein kinases (ROCK I and II) used in cellular and pharmacological research to modulate ROCK signaling. Supplied as a high-purity solid, it is commonly used in cell signaling studies, pharmacodynamic assays, and stem cell culture applications that require ROCK pathway inhibition.
- ATP-competitive inhibitor of ROCK I and II with reported activity in the low hundreds of nanomolar range.
- High purity suitable for research applications.
- Solid form for easy handling and storage.
- Available in research-scale package sizes for laboratory use.
- Applicable to cell signaling, pharmacology, and stem cell culture studies.
Medchemexpress LLC Y-27632 | 146986-50-7 | MFCD03093855 | 247.34 g/mol | C14H21N3O | 1 ML
Y-27632 is a selective, ATP-competitive Rho-associated kinase (ROCK) inhibitor provided as a ready-to-use 10 mM solution in DMSO (1 mL). It is commonly used in cell biology to promote survival of dissociated cells, investigate cytoskeletal dynamics, and modulate ROCK signaling. The compound has molecular formula C14H21N3O, molecular weight 247.34 g/mol, and CAS 146986-50-7.
- Selective inhibitor of ROCK I and ROCK II.
- Ready-to-use 10 mM solution in DMSO for convenient dosing.
- Supports improved survival of dissociated cells in culture.
- Useful for studying cytoskeletal remodeling and cell motility.
- Documented biochemical potency in the low hundreds of nanomolar range.
- Soluble in DMSO for preparation of concentrated stock solutions.
Medchemexpress LLC (4S)-PROTAC SOS1 degrader-1 | 2913176-81-3 | C57H76ClFN10O4S | 50 MG
(4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. It decreases the expression of pERK and RAS-GTP levels in a dose-dependent manner. It also significantly inhibits tumor growth in vivo.
- Shows potent SOS1 degradation activity with 56.2% and 92.5% SOS1 protein degradation at 0.1 and 1 μM, respectively, in NCI-H358 cells.
- Degrades SOS1 in a dose- and time-dependent manner in NCI-H358 cells (24 h incubation).
- Does not induce SOS2 and KRAS degradation in NCI-H358 cells (9.8-2500 nM; 24 h).
- Decreases the expression of pERK and RAS-GTP levels in NCI-H358 cells in a dose-dependent manner (7.8-2000 nM; 24 h).
- Significantly inhibits tumor growth in vivo.
Selleck Chemical LLC Y-320
Y-320 is an orally active immunomodulator and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM
Medchemexpress LLC VISTA/B7-H5 Rat HE 50ug
VISTA/B7-H5 protein an immunoregulatory receptor inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling It also stimulates MMP14-mediated MMP2 activation suggesting a role in matrix metalloproteinase processes These roles highlight the significance of VISTA/B7-H5 in immune regulation embryonic development and extracellular matrix dynamics VISTA/B7-H5 Protein Rat (HEK293 Fc) is the recombinant rat-derived VISTA/B7-H5 protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC VISTA/B7-H5 Rat HE 500ug
VISTA/B7-H5 protein an immunoregulatory receptor inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling It also stimulates MMP14-mediated MMP2 activation suggesting a role in matrix metalloproteinase processes These roles highlight the significance of VISTA/B7-H5 in immune regulation embryonic development and extracellular matrix dynamics VISTA/B7-H5 Protein Rat (HEK293 Fc) is the recombinant rat-derived VISTA/B7-H5 protein expressed by HEK293 with C-hFc labeled tag
Medchemexpress LLC TCS 2510 | 346673-06-1 | 98.3% | 383.49 | 1 ML
TCS 2510 is a selective EP4 agonist. It can be used for the research of metabolic diseases. This product is for research use only and not sold to patients.
- Stimulates glucagon like peptide 1 secretion in GLUTag cells.
- Activates the Gas signaling pathway.
- Increases Gcg mRNA expression levels in GLUTag cells.
- Produces a concentration-dependent increase in cAMP levels.
- Elevates plasma glucagon like peptide 1 levels in fasted mice.