Pyrazoles
Medchemexpress LLC Phenol, 4-(di-1H-indol-3-ylmethyl)- | 151358-47-3 | 98.1% | 338.40 | 25 MG
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. It inhibits cancer cell growth and mTOR signaling, and induces apoptosis and cellular stress. It reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells.
- Nuclear receptor 4A1 (NR4A1) antagonist
- Inhibits cancer cell growth and mTOR signaling
- Induces apoptosis and cellular stress
- Reduces cell proliferation in ACHN and 786-O cells
- Inhibits NR4A1-regulated expression (survivin, bcl-2, EGFR)
- Induces sestrin 2, activates AMPKα, inhibits mTOR and downstream kinases
- Decreases β1-integrin protein, mRNA, and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells
- Inhibits migration of MDA-MB-231 and SKBR3 cells
- Significantly inhibits tumor growth in male athymic nude mice (ACHN cells)
Medchemexpress LLC SU-4942 | 76086-99-2 | 99.6% | 300.15 | 10 MM * 1 ML
SU-4942 is a tyrosine kinase signal modulator that inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells.
- Tyrosine kinase signal modulator.
- Inhibits VEGF- and endothelial cell growth factor (ECGF)-induced mitogenesis in endothelial cells.
- For research use only.
Medchemexpress LLC Dim-c-pphoh | 151358-47-3 | 99.0% | 338.40 | 1 ML
DIM-C-pPhOH is an antagonist of nuclear receptor 4A1 (NR4A1). It inhibits cancer cell growth, mTOR signaling, and induces apoptosis and cellular stress. It also reduces cell proliferation with IC50 values of 13.6 μM for ACHN cells and 13.0 μM for 786-O cells.
- NR4A1 antagonist.
- Inhibits cancer cell growth and mTOR signaling.
- Induces apoptosis and cellular stress.
- Reduces cell proliferation in ACHN and 786-O cells.
- Inhibits NR4A1-regulated expression of survivin, bcl-2, and EGFR.
- Activates AMPKα and inhibits mTOR.
- Decreases expression of β1-integrin protein and mRNA.
- Inhibits migration of MDA-MB-231 and SKBR3 cell lines.
- Inhibits tumor growth in male athymic nude mice.
Medchemexpress LLC Phenol, 4-(di-1H-indol-3-ylmethyl)- | 151358-47-3 | 98.1% | 338.40 | 10 MG
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. It inhibits cancer cell growth and mTOR signaling, while inducing apoptosis and cellular stress. This compound has been shown to reduce cell proliferation in various cell lines.
- Significantly decreases cell proliferation
- Induces apoptosis and cleavage of caspases 7 and 8
- Inhibits NR4A1-regulated expression of survivin, bcl-2, and EGFR
- Activates AMPKα and inhibits activation of mTOR and downstream kinases
- Decreases expression of β1-integrin protein and mRNA
- Inhibits migration of breast cancer cell lines
- Significantly inhibits tumor growth in an animal model
TARGETMOL CHEMICALS INC DIM-C-PPHOH 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonistinhibits TGF-(beta) induced cell migration of breast cancer cell linespromotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell linesmimics effects of Nur77 RNAi silencing. purity: 99%
Medchemexpress LLC DIM-C-pPhOCH3 | 33985-68-1 | 99.4% | 352.43 | 1 ML
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor. This product is for research use only.
- Decreases survival and induces apoptosis in RKO colon cancer cells, accompanied by induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein.
- Induces Nur77-independent apoptosis.
- Inhibits cell growth after treatment for 24, 48, or 72 h, with maximum inhibitory response observed after 72 h, leading to considerable cell detachment and dead cells.
- Growth-inhibitory effects after 72 h are accompanied by markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8.
- Inhibits tumor growth in athymic nude mice bearing RKO cell xenografts.
- Significantly decreases tumor volumes and final tumor weights compared with corn oil controls in athymic nude mice bearing RKO cell xenografts.
Medchemexpress LLC NANOG Human His-SU 10ug
NANOG Protein Human (His-SUMO) which functions to maintain the undifferentiated state of pluripotent stem cells
Medchemexpress LLC DIM-C-pPhOCH3 | 33985-68-1 | 99.4% | 352.43 | 25 MG
DIM-C-pPhOCH3 is a Nur77 agonist. Nur77 (Nerve growth factor-induced Bα, NGFI-Bα) is an orphan nuclear receptor. It is used for research purposes only. In vitro, DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, accompanied by the induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein. It also induces Nur77-independent apoptosis. In vivo, DIM-C-pPhOCH3 inhibits tumor growth in athymic nude mice bearing RKO cell xenografts.
- Nur77 agonist
- Induces apoptosis in RKO colon cancer cells
- Inhibits tumor growth in athymic nude mice bearing RKO cell xenografts
- Suitable for research applications
Medchemexpress LLC DIM-C-pPhOCH3 | 33985-68-1 | 99.41% | 352.43 | 10 MG
DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor. This product is for research use only.
- Decreases survival and induces apoptosis in RKO colon cancer cells.
- Induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein.
- Inhibits cell growth after 24, 48, or 72 h.
- Inhibits tumor growth in athymic nude mice bearing RKO cell xenografts.
Medchemexpress LLC NANOG Human His-SU 50ug
NANOG Protein Human (His-SUMO) which functions to maintain the undifferentiated state of pluripotent stem cells
Medchemexpress LLC NANOG Human His-SU 5ug
NANOG Protein Human (His-SUMO) which functions to maintain the undifferentiated state of pluripotent stem cells
Apexbio Technology LLC DIM-C-pPhOH 151358-47-3 25mg
DIM-C-pPhOH (CAS 151358-47-3) is a small-molecule antagonist that targets the nuclear receptor NR4A1 (nuclear receptor subfamily 4 group A member 1) It has been shown to inhibit tumor cell proliferation by modulating the mTOR signaling pathway induce apoptosis and activate cellular stress responses In in vitro studies using human renal carcinoma cell lines ACHN and 786-O DIM-C-pPhOH demonstrated inhibitory effects on cell proliferation with IC50 values of 13 6 M and 13 0 M respectively This compound serves as a valuable tool for investigating tumor-associated signaling pathways and the mechanisms underlying anticancer therapeutics
Apexbio Technology LLC DIM-C-pPhOH 151358-47-3 10mg
DIM-C-pPhOH (CAS 151358-47-3) is a small-molecule antagonist that targets the nuclear receptor NR4A1 (nuclear receptor subfamily 4 group A member 1) It has been shown to inhibit tumor cell proliferation by modulating the mTOR signaling pathway induce apoptosis and activate cellular stress responses In in vitro studies using human renal carcinoma cell lines ACHN and 786-O DIM-C-pPhOH demonstrated inhibitory effects on cell proliferation with IC50 values of 13 6 M and 13 0 M respectively This compound serves as a valuable tool for investigating tumor-associated signaling pathways and the mechanisms underlying anticancer therapeutics
Apexbio Technology LLC DIM-C-pPhOH 151358-47-3 5mg
DIM-C-pPhOH (CAS 151358-47-3) is a small-molecule antagonist that targets the nuclear receptor NR4A1 (nuclear receptor subfamily 4 group A member 1) It has been shown to inhibit tumor cell proliferation by modulating the mTOR signaling pathway induce apoptosis and activate cellular stress responses In in vitro studies using human renal carcinoma cell lines ACHN and 786-O DIM-C-pPhOH demonstrated inhibitory effects on cell proliferation with IC50 values of 13 6 M and 13 0 M respectively This compound serves as a valuable tool for investigating tumor-associated signaling pathways and the mechanisms underlying anticancer therapeutics
Medchemexpress LLC Phthalazinone pyrazole | 880487-62-7 | MFCD28399120 | 98.0% | 317.34 | C18H15N5O | 10MG
Phthalazinone pyrazole is a potent, selective, orally active small-molecule inhibitor of Aurora-A kinase used for research in cell biology and oncology. It has a biochemical IC50 of 0.031 μM against Aurora-A and shows cellular activity in multiple cancer cell lines.
- Potent Aurora-A kinase inhibition (IC50 0.031 μM).
- Demonstrated cellular activity in COLO 205, HCT-116, and MCF7 cell lines.
- High purity suitable for research (98.0%).
- Well-characterized physicochemical properties (C18H15N5O; MW 317.34).
- Available as solid and solution formats for assay flexibility.
- Supplied with a datasheet containing analytical and handling information.