Thiazoles
Medchemexpress LLC TH-6 | 3031349-25-1 | 95.0% | 429.44 | 50 MG
TH-6 is a potent HDAC inhibitor that shows anti-tumor activity. It inhibits cell migration and invasion, and induces apoptosis and cell cycle arrest at G2/M phase.
- Potent HDAC inhibitor with specific IC50s for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8.
- Inhibits cell migration and invasion.
- Induces apoptosis and cell cycle arrest at G2/M phase.
- Shows anti-tumor activity in mice models.
- Exhibits antiproliferative activities in various cancer cell lines and normal human lung cells.
- Inhibits tubulin polymerization.
- Increases expression of Ac-α-Tubulin and AC-Histone H3 in HepG2 cells.
- Shows favorable liver microsomal stability in vitro.
Medchemexpress LLC TERT activator-1 | 666699-46-3 | 99.5% | 331.77 | 50 MG
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). It promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. It offers several benefits:
- Promotes adult neurogenesis.
- Enhances neuromuscular function.
- Reduces cellular senescence and systemic inflammation in aged mice.
- Can be used in the study of aging.
Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 50 MG
JH-VIII-157-02 is a structural analogue of alectinib and functions as an Anaplastic Lymphoma Kinase (ALK) inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK mutations and shows selectivity at other kinases. The compound also exhibits inhibitory growth against several cancer cell lines and good oral bioavailability in vivo.
- Potent ALK inhibitor
- Inhibits various EML4-ALK mutations
- Selective inhibition against kinases such as IRAK1, CLK4, and RET
- Inhibits growth of cancer cell lines like H3122 and DFCI76 (L1152R)
- Good oral bioavailability and CNS penetration
- Soluble in DMSO at concentrations ≥ 25 mg/mL
Medchemexpress LLC JQ-1 (carboxylic acid) | 202592-23-2 | 99.7% | 400.88 | 50 MG
JQ-1 carboxylic acid is a potent BET bromodomain inhibitor, derived from (+)-JQ-1. It is utilized for synthesizing PROTACs that target the degradation of BRD4. This compound is an off-white to yellow solid with a molecular weight of 400.88 and the chemical formula C19H17ClN4O2S.
- Potent BET bromodomain inhibitor.
- Used to synthesize PROTAC, targeting BRD4 degradation.
- Soluble in DMSO (100 mg/mL).
- Downregulates PD-L1 expression on B16F10 cells in vitro.
- Applicable in various disease areas including cancer, and signaling pathways such as epigenetics and immunology/inflammation.
- Store powder at -20°C for 3 years or 4°C for 2 years.
Medchemexpress LLC N-benzyl-N-butyl-4-(phenylsulfamoyl)benzamide | 2244678-29-1 | 98.4% | 50 MG
TH-257 (CAS 2244678-29-1) is a small-molecule allosteric inhibitor of LIM kinase 1 and 2 used as a biochemical research probe to study LIMK-mediated signaling pathways in vitro.
- Potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM.
- Molecular formula C24H26N2O3S and molecular weight 422.54 g/mol.
- High purity (98.36%) suitable for in vitro biochemical studies.
- Supplied as a solid powder and as a 10 mM solution in DMSO; common pack sizes include 5 mg, 10 mg, 50 mg, and 100 mg.
Medchemexpress LLC 1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide | 174899-83-3 | MFCD05664714 | 99.9% | 419.36 | 50 G
1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (compound 8) is an HIV-1 integrase inhibitor that effectively inhibits both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration reaction. It can be utilized in HIV-1 research.
- Effectively inhibits HIV-1 integrase
- Inhibits 3'-processing step
- Inhibits strand transfer step
- Suitable for HIV-1 research
Medchemexpress LLC 1,2:5,6-Bis-O-(1-methylethylidene)-α-D-allofuranose | 2595-05-3 | 260.28 | 50 G
1,2:5,6-Bis-O-(1-methylethylidene)-α-D-allofuranose is a biochemical reagent primarily used in glycobiology research. This compound aids in the study of sugars, including carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. Its applications span basic research, biomedicine, and biotechnology.
- White to off-white solid
- Used in glycobiology research
- Supports studies on sugar structure, synthesis, and evolution
- Relevant for carbohydrate chemistry, enzymology, and protein-glycan recognition
- Suitable for basic research, biomedicine, and biotechnology applications
- For scientific research or drug registration application only
Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone | 141627-42-1 | 99.6% | C20H19NO5 | 50 G
(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone is a chemical compound functioning as a drug intermediate for the synthesis of various active compounds. It is designated for research use only.
- Functions as a drug intermediate for active compound synthesis
- Intended for research use only
- High purity of 99.6%
- Appears as a solid
- Color ranges from yellow to brown
Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone | 141645-16-1 | 99.6% | C19H17NO5 | 50 G
This chemical is a drug intermediate utilized in the synthesis of various active compounds. It is intended for research purposes only and not for patient use.
- Drug intermediate
- Solid appearance
- Off-white to yellow color
Medchemexpress LLC (3-methyloxiran-2-yl)methanol | 872-38-8 | MFCD00033455 | 95.0% | 88.11 g·mol⁻1 | C4H8O2 | 50 MG
(3-Methyloxiran-2-yl)methanol is an epoxy-containing primary alcohol used as a synthetic building block and drug intermediate for small-molecule research. It has formula C4H8O2 (MW 88.11 g·mol⁻1) and CAS 872-38-8. Typical supplied purity is 95.0% (by NMR), and the product is offered in small research pack sizes.
Medchemexpress LLC Tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | 571188-59-5 | 99.97% | 278.36 | 50 G
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a drug intermediate used for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Drug intermediate
- For synthesis of various active compounds
Medchemexpress LLC (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylt | 2097381-85-4 | MFCD30742947 | 99.5% | 523.65 g/mol | C27H33N5O4S | 50 MG
VH-298 is a cell-permeable inhibitor of the VHL:HIF-α interaction that induces HIF-α accumulation and serves as an E3 ligase ligand for PROTAC synthesis. It is potent (Kd 80-90 nM), shows minimal off-target activity in broad panels, and is suitable as a chemical probe for studying hypoxic response and targeted protein degradation.
- Highly potent VHL:HIF-α interaction inhibitor (Kd 80-90 nM).
- Induces HIF-α accumulation in human cell lines.
- Functions as an E3 ligase ligand for PROTAC synthesis.
- Cell-permeable with low cellular toxicity.
- Minimal off-target activity across kinase, GPCR, and ion channel panels at 50 μM.
- High purity and defined storage and solubility profiles for experimental use.
Medchemexpress LLC Octanoic acid, 8-bromo-, 1-octylnonyl ester | 2089253-22-3 | MFCD34178802 | 97.0% | 461.56 g/mol | C25H49BrO2 | 50 MG
Heptadecan-9-yl 8-bromooctanoate is a brominated lipid ester supplied for research use as a hydrophobic building block for lipid nanoparticles (LNPs) and related lipid formulations. It is used in lipid chemistry and formulation development to introduce a brominated alkyl chain for downstream modification and formulation studies.
- Brominated lipid ester for LNP construction.
- Useful as a hydrophobic building block in lipid formulations.
- Chemical formula C25H49BrO2; molecular weight 461.56 g/mol.
- CAS number 2089253-22-3 for unambiguous identification.
- Purity 97.0% as supplied.
- Storage: pure form -20°C up to 3 years; in solvent -80°C (6 months) or -20°C (1 month).
- Available in multiple pack sizes including solution and solid forms.
Medchemexpress LLC Imidazo[1,2-a]pyrazine, 8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | 3023925-68-7 | C25H26N6O | 50 MG
YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis and has shown to ameliorate liver damage in an Acetaminophen (APAP)-induced acute liver injury model.
- Potent ferroptosis inhibitor
- Targets the PHB2/ferritin/iron axis
- Protects cells from ferroptosis
- Reduces ROS levels in cytosolic and membrane lipids
- Inhibits ferritinophagy by improving ferritin protein expression
- Ameliorates liver damage in APAP-induced acute liver injury models
- High purity of 99.03%
- Solid appearance, off-white to light yellow color
eMolecules Ambeed 2 5-Dioxopyrrolidin-1-yl 2 5 8 11 14 17 20 23 26 29 32 35 38 41 44 47-hexadecaoxapentacontan-50-oate 50mg 811906054 A1662119 0 000 2563873-83-4 MFCD13184971 861 973 C38H71NO20
Ambeed 2 5-Dioxopyrrolidin-1-yl 2 5 8 11 14 17 20 23 26 29 32 35 38 41 44 47-hexadecaoxapentacontan-50-oate 50mg 811906054 A1662119 0 000 2563873-83-4 MFCD13184971 861 973 C38H71NO20