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Filtered Search Results
Frontier Specialty Chemicals Tetracycline hydrochloride, 64-75-5, MFCD00078142, 5g
Molecular Formula C22H25ClN2O8, Molecular Weight 480.900
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Medchemexpress LLC Vu0155041 | 1093757-42-6 | 99.10% | C14H15Cl2NO3 | 50 MG
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VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD).
- Potent and selective positive allosteric modulator (PAM) of mGluR4
- EC50s of 798 nM for human mGluR4
- EC50s of 693 nM for rat mGluR4
- Potential for Parkinson's disease research
- Does not affect NMDA receptor currents in striatal medium spiny neurons at 10 μM in vitro
- Reverses catalepsy induced by dopamine D2 receptor antagonist Haloperidol in rats
- Reverses Reserpine-induced akinesia in rats
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Medchemexpress LLC Calpain Inhibitor III | 88191-84-8 | 97.0% | 382.45 | 50 MG
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MDL-28170 (Calpain Inhibitor III) is a potent, selective, and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration. MDL-28170 also blocks γ-secretase. It significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization. MDL-28170 dose-dependently inhibits brain cysteine proteinase activity.
- Potent, selective and membrane-permeable cysteine protease inhibitor of calpain.
- Rapidly penetrates the blood-brain barrier following systemic administration.
- Blocks γ-secretase.
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Medchemexpress LLC Ponatinib-d8 (AP24534-d8) | 1562993-37-6 | 99.9% | 1 MG
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Ponatinib-d8 is a deuterium-labeled analogue of ponatinib used as a stable isotope internal standard for quantitative mass spectrometry and pharmacokinetic assays. It provides accurate normalization for LC-MS/MS workflows and supports method validation and PK sample analysis.
- Deuterium-labeled internal standard for LC-MS/MS assays.
- High chemical and isotopic purity for reliable quantitation.
- Suitable for bioanalytical method validation and PK studies.
- Offered in small, convenient quantities for analytical use.
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Medchemexpress LLC Orantinib | 252916-29-3 | 98.5% | 310.35 | C18H18N2O3 | 5 MG
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Orantinib (SU6668; TSU-68) is a small-molecule, multi-targeted receptor tyrosine kinase inhibitor used in preclinical research. It inhibits VEGFR (Flt-1), PDGFRβ, and FGFR1 with reported Kis of 2.1 μM, 8 nM, and 1.2 μM, respectively. The compound has molecular formula C18H18N2O3, molecular weight 310.35, CAS 252916-29-3, and is provided as a purified research reagent.
- Inhibits VEGFR (Flt-1), PDGFRβ, and FGFR1 with documented Ki values.
- Exhibits antiangiogenic and antitumor activity in preclinical studies.
- Supplied as a purified research-grade small molecule with reported purity around 98.5%.
- Available in multiple sizes suitable for assay development and in vivo dosing studies.
- Suitable for target validation, pathway studies, and pharmacology experiments.
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eMolecules 1173097-76-1 | U0126 Ethanol | MFCD25977152 | 10mg
Ambeed | Ethyl 2-(24-difluorophenyl)-22-difluoroacetate | 250mg | 600842201 | A516373 | 1228957-05-8 | MFCD16618951 | 236.166 | C10H8F4O2
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Apexbio Technology LLC Betamipron 3440-28-6 50mg
Betamipron (CAS 3440-28-6) is a small-molecule inhibitor targeting renal tubular uptake mechanisms It is designed to inhibit renal tubular uptake thereby reducing nephrotoxicity during carbapenem antibiotic therapy Betamipron exerts its biological activity primarily through blockade of the renal tubular uptake process Its potency is typically assessed via renal uptake assays and cellular transporter inhibition tests however exact IC50 values depend on experimental conditions and models and are not explicitly provided Based on these pharmacological properties Betamipron holds research potential in the investigation of antibiotic-related renal pharmacokinetics carbapenem distribution profiles and nephrotoxic side-effects
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eMolecules 185991-07-5 | Medchem Express | AMD 3465 (hexahydrobromide) | 5mg | 506404074 | HY-15971 | MFCD20926342 | 896.082 | C24H44Br6N6
Ambeed | 5-Bromo-4-hexylthiophene-2-carbaldehyde | 100mg | 633658579 | A802831 | 291535-21-2 | 275.200 | C11H15BrOS
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Medchemexpress LLC Vancomycin hydrochloride | 1404-93-9 | 99.4% | 1485.71 | 1 ML
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Vancomycin hydrochloride is an antibiotic used for treating bacterial infections. Its mechanism of action involves inhibiting the second stage of cell wall synthesis in susceptible bacteria. Additionally, vancomycin modifies the permeability of the cell membrane and selectively prevents ribonucleic acid synthesis. This product is for research use only and has not been fully validated for medical applications.
- Inhibits bacterial cell wall synthesis
- Modifies cell membrane permeability
- Selectively inhibits ribonucleic acid synthesis
- Acts as an antibiotic
- Relevant for autophagy research
- Applicable in infection research
- Used in cancer research
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Medchemexpress LLC HY-103315 10mg Medchemexpress, Bepridil hydrochloride CAS:68099-86-5 Purity:>98%
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Medchemexpress, HY-103315 10mg Bepridil HCl CAS:68099-86-5 Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC DHODH-IN-17 | 16344-26-6 | 99.9% | 10 MG
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DHODH-IN-17 is a 2-anilino nicotinic acid and a human DHODH inhibitor with an IC50 value of 0.40 μM. It is intended for research purposes, specifically in the study of acute myeloid leukemia (AML). Its molecular weight is 248.67, with a chemical formula of C12H9ClN2O2, and it appears as an off-white to gray solid.
- Inhibits human DHODH with an IC50 of 0.4 μM.
- Induces differentiation in bone marrow cells (EC50 of 3 μM).
- Induces differentiation in THP-1 cells (EC50 of 10.7 μM).
- Induces differentiation in U-937 cells (EC50 of 6.1 μM).
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Medchemexpress LLC VU0463271 | 1391737-01-1 | 99.8% | 382.50 | 10 MG
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VU0463271 is a selective and potent KCC2 antagonist. It demonstrates high selectivity over NKCC1 and no activity against a broad panel of GPCRs, ion channels, and transporters. In vitro, it is rapidly cleared. In vivo studies in rats show it is a moderate-to-high clearance compound.
- IC50 of 61 nM for KCC2.
- >100-fold selectivity over NKCC1.
- No activity against GPCRs, ion channels, and transporters.
- Rapidly cleared in vitro.
- Significantly increased firing rates in Drosophila CNS.
- Moderate-to-high clearance (CL=57 mL/min/kg) in rats after intravenous administration.
- Low volume of distribution at steady state (Vss 0.4 L/kg) in rats.
- Relatively short t1/2 (9 min) in rats.
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Medchemexpress LLC HY-101792 10mg Medchemexpress, RG7800 CAS:1449598-06-4 Purity:>98%
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Medchemexpress, HY-101792 10mg RG7800 CAS:1449598-06-4 RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC 4-(2′-aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline | 445430-58-0 | MFCD18089812 | 99.7% | 255.32 g·mol⁻1 | C14H17N5 | 25 MG
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BMS-345541 is a small-molecule research reagent that selectively inhibits the catalytic subunits of IκB kinase (IKK). It binds an allosteric site on IKK and is used to probe NF-κB signaling pathways in biochemical and cellular studies. The compound is supplied with analytical characterization for research use only.
- Selective inhibition of IKK catalytic subunits, with greater potency for IKK-2
- Binds an allosteric site on the IKK enzyme
- Reported IC50 values: IKK-2 = 0.3 μM; IKK-1 = 4 μM
- High analytical purity suitable for research applications
- Available in multiple pack sizes, including 25 MG
- Molecular formula C14H17N5 and molecular weight 255.32 g·mol⁻1
- Offered as solid and as ready-to-use DMSO solution formats
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Apexbio Technology LLC OLIGOMYCIN COMPLEX 5MG
OLIGOMYCIN COMPLEX 5MG APEXBIO TECHNOLOGIES
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