Sera
Cayman Chemical ClevIdIpIn 100mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)
Cayman Chemical Importazole 50mg
An inhibitor of importin-β-mediated nuclear import (IC50 = 15 μM in HEK293 cells); does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export
Cayman Chemical 3amInoLTyrosInhydrochlo 100mg
A tyrosine derivative; completely inhibits the growth of a tyrosine-sensitive mutant of N. crassa at 400 µM; cytotoxic to KG-1 leukemia cells at 200-400 UG/ml; dietary administration decreases fecundity and hatchability of eggs of B. oleae at 0.01 g/100 ml, as well as survival of adult B. oleae at 6 g/100 ml
Cayman Chemical DIhydroxyaceton PhosphATm 50mg
A glycerolipid precursor; erythrocyte levels are increased in patients with triosephosphate isomerase deficiency
Cayman Chemical DLthreoHydroxyaspartIc Ac 50mg
An EAAT inhibitor; inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s = 96 and 31 µM, respectively); inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 0.6 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 2.5 µM) voltage-clamped at -60 mV; intrathecal administration (7.5 and 15 UG/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats
Cayman Chemical StevIolbIosIde 50mg
A natural non-caloric sweetener and an active metabolite of rebaudioside A; inhibits the proliferation of MDA-MB-231 cells at 250 UG/ml; active against M. tuberculosis (MIC = 3.75 UG/ml)
Cayman Chemical MethapyrIlenhydrochLRIde 100mg
An H1 receptor antagonist (Ki = 4.5 nM) and non-genotoxic carcinogen; induces liver tumors in rats at 0.1% in the diet; decreases H3K9 and H3K56 acetylation, as well as H3K4 di- and H4K20 trimethylation, in rat liver at 40 mg/kg per day for six weeks
Cayman Chemical GSK1838705A 50mg
An IGF-1R and IR inhibitor (IC50s = 2 and 1.6 nM, respectively); selective for IGF-1R and IR over a panel of 47 kinases (IC50s = >1,600 nM); inhibits ALK (IC50 = 0.5 nM); inhibits ligand-induced phosphorylation of IGF-1R and IR as well as phosphorylation of Akt, IRS-1, and ERK in MCF-7 breast carcinoma cells; inhibits the growth of a panel of cancer cell lines (EC50s = 24-8,378 nM); completely inhibits IGF-1-induced phosphorylation of IGF-IR, Akt, and IRS-1 as well as reduces tumor growth in the COLO 205 and NIH-3T2/LISN mouse xenograft models at ≥1 and ≥10 mg/kg, respectively; induces tumor cell apoptosis and reduces tumor growth in U87MG glioma and PC3R prostate cancer mouse xenograft models
Cayman Chemical MefloquInhydrochlorIde 100mg
An antimalarial compound; increases mean survival time and abolishes malarial infection in mice at doses of 10 and 40 mg/kg, respectively; inhibits hemozoin formation, leading to an increase in free heme in purified trophozoites; A2A receptor antagonist; 5-HT2A and 5-HT2C agonist; has various effects on calcium homeostasis; has effects in mice typically associated with anxiolytic and antidepressant-like behavior
Cayman Chemical CLOrophenol Red DGalactop 50mg
A colorimetric β-galactosidase substrate; upon enzymatic cleavage by β-galactosidase, chlorophenol red is released, which can be quantified by colorimetric detection at 570 nm as a measure of β-galactosidase activity
Cayman Chemical 4methoxyN NDImthylcathIno 50mg
An analog of methedrone, differing by the presence of a second aminomethyl group; intended for forensic and research applications
Cayman Chemical FlucloxacIlInsodIum salt 100mg
A β-lactam antibiotic; active against clinical isolates of S. aureus (MICs = 0.12-0.25 mg/L); decreases vegetation titers in a rat model of S. aureus-induced aortic valve endocarditis at 42.3 mg/kg every six hours
Cayman Chemical 2 5-nhydro-D-mnItol 50mg
An antimetabolic fructose analogue that increases food intake in rats
Cayman Chemical AzatdInmaleate 50mg
An antihistamine with anticholinergic and antiserotonergic activities; histamine H1 receptor antagonist (Ki = 3.9 nM); inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and 5-HT-induced contractions in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively); delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs; prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 μg/kg, respectively); increases survival in guinea pig and mouse models of anaphylactic shock (PD50s = 0.024 and 0.019 mg/kg, respectively)
Cayman Chemical LoxapInsuccInate 50mg
An atypical antipsychotic drug that displays high affinity for histamine (H), serotonin (5-HT), dopamine (D), and α1-adrenergic receptors (Ki values are 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A, respectively)