Sera
Cayman Chemical Fidaxomycin, Purity: ≥95%, CAS: 873857-62-6, 50 mg
A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml)
Cayman Chemical D-Carnitine, Purity: ≥98%, CAS: 541-14-0, 100 mg
An isomer of L-carnitine; inhibits L-carnitine uptake by rat kidney brush border membrane vesicles at 50 µM and by primary HCLE and HCjE cells at 0.5 and 1 mM
Cayman Chemical 7-Methylguanine, Purity: ≥98%, CAS: 578-76-7, 50 mg
A metabolite of the natural purine base that is generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods; carcinogenic biomarker for cigarette smoking that is detectable in urine
Cayman Chemical TMPyP4 (tosylate), Purity: ≥95%, CAS: 36951-72-1, 50 mg
A cationic porphyrin that intercalates into and stabilizes G-quadruplexes; inhibits telomerase activity (IC50 ≤ 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo
Cayman Chemical N-nonanoyl-L-Homoserine lactone, Purity: ≥98%, CAS: 177158-21-3, 50 mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM
Cayman Chemical 5-trans Fluprostenol isopropyl ester, Purity: ≥95%, CAS: 1563176-59-9, 50 mg
A potential impurity in commercial preparations of travoprost
Cayman Chemical Irinotecan (hydrochloride hydrate), Purity: ≥98%, CAS: 136572-09-3, 100 mg
A derivative of the alkaloid camptothecin that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I; demonstrates a broad spectrum of antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors
Cayman Chemical Resorcinolnaphthalein, Purity: ≥98%, CAS: 41307-63-5, 50 mg
Increases the activity of angiotensin-converting enzyme 2 (ACE2) in vitro (EC50 = 19.5 μM)
Cayman Chemical Emtricitabine, Purity: ≥98%, CAS: 143491-57-0, 50 mg
An antiviral nucleoside analog; an inhibitor of HIV-1 and hepatitis B reverse transcriptase; inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines; inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes; reduces viremia and hepatic WHV replication in a dose-dependent manner in a woodchuck model of chronic WHV infection
Cayman Chemical Cryptotanshinone, Purity: ≥95%, CAS: 35825-57-1, 50 mg
A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells; inhibits SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells; has a variety of anti-cancer actions
Cayman Chemical 1a,1b-dihomo Prostaglandin E2, Purity: ≥98%, CAS: 26198-80-1, 5 mg
A rare PUFA produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGES
Cayman Chemical 15(S)-Latanoprost, Purity: ≥98%, CAS: 145773-22-4, 50 mg
A 15(S) isomer of latanoprost; reduces IOP in cynomolgus monkeys and does not induce eye irritation in cats when applied topically at 3 µg/eye; a potential impurity in commercial preparations of latanoprost
Cayman Chemical Cytidine 5'-triphosphate (sodium salt hydrate), Purity: ≥95%, CAS: 652154-13-7, 100 mg
A pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions, including RNA synthesis, the formation of PC, and sialylation
Cayman Chemical D-Mannoheptulose, Purity: ≥98%, CAS: 3615-44-9, 50 mg
A heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM); blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells
Cayman Chemical N1-Acetylspermine (hydrochloride), Purity: ≥95%, CAS: 77928-70-2, 50 mg
A monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine