Human Sera
Cayman Chemical FursultIamIn 100mg
A dual inhibitor of EGFR and HER2 (IC50s 22 and 32 nM respectively) selective for EGFR and HER2 over HER4 (IC50 190 nM) and a panel of 21 additional kinases (IC50s 2500 nM for all) inhibits proliferation in a panel of EGFR and/or HER2 signaling-dependent cancer cells (IC50s 0.24-0.94 M) reduces tumor growth in a Sal2 murine salivary gland tumor model as well as GEO colon and KPL4 breast cancer mouse xenograft models in a dose-dependent manner reduces tumor cell motility intravasation and EGF-induced invasion in an MTLn3E metastatic mammary adenocarcinoma mouse xenograft model at 100 mg/kg
Cayman Chemical AdenylosuccInIc ACDamonIu 50mg
A K-opioid receptor antagonist (Ki 0.18 nM) selective for K-opioid receptors over U- and -opioid receptors in radioligand binding assays (Kis 36.9 and 70 nM respectively) inhibits agonist-induced [35S]GTPYS binding in CHO cells expressing human K-opioid receptors (pA2 10.4) induces scratching behavior in mice at 0.3 mg/kg
Cayman Chemical N 3PhenylpropIonylglycIn 100mg
A dual VEGFR and PDGFR family kinase inhibitor (IC50s 0.002 0.05 0.004 and 0.015 UM for VEGFR1 VEGFR2 PDGFRB and KIT respectively) selective for these kinases over FGFR1 EGFR Src and c-Met (IC50s 3.5 20 2.5 and 9 UM respectively) inhibits VEGFR2 PDGFRB KIT and FLT3-ITD phosphorylation in vitro (IC50s 0.04 0.02 0.006 and 0.05 UM respectively) inhibits PDGF-dependent proliferation of NIH3T3 cells overexpressing PDGFRB as well as OC1-AML5 cells expressing wild-type FLT3 and MV4-11 cells carrying the activating FLT3-ITD mutation inhibits VEGF-induced survival of HUVECs (IC50 6.8 nM) reduces tumor growth in human acute myeloid leukemia renal and colon cancer as well as rat glioma mouse xenograft models when used at doses ranging from 10-80 mg/kg twice per day
Cayman Chemical 7-ChlorokynurenIc AcId 50mg
An internal standard for the quantification of meglutol by GC- or LC-MS
Cayman Chemical LevobetaxololhydroCLOrID 100mg
An analytical reference standard categorized as a cathinone intended for research and forensic applications
Cayman Chemical 28-AcetalbetulIn 100mg
An antiparasitic agent induces swelling and blebbing and reduces motility of F. hepatica mature flukes at 10 Ug/ml reduces the number of flukes in a goat model of F. hepatica infection from 3.5-15 mg/kg completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle at 7 mg/kg
Cayman Chemical TrIbenosIde 100mg
A dopamine D3 receptor agonist selectively binds to the dopamine D3 over the D2 D1 and D4 receptors (Kis 0.78 61 650 and 5300 nM respectively in radioligand binding assays) increases calcium mobilization in HEK293 cells expressing the D3 receptor (EC50 13.5 nM in a FLIPR assay) decreases the release of striatal dopamine and DOPAC in rats at 0.25 mg/kg i.p. reduces the loss of ipsilateral SNC dopaminergic neurons in a rat model of 6-OHDA-induced Parkinsons disease at 2 Ug/Ul for eight weeks i.c.v. decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model
Cayman Chemical 2-OxoadIpIc AcId 50mg
An alkaloid with diverse biological activities active against S. aureus S. faecalis and C. albicans (MIC 1.87 g/ml for all) inhibits secretion of the HBV antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s 50s 1.4 0.4 and 3.5 M respectively)
Cayman Chemical PIlsIcaInIdehydrochLRIde 100mg
A dual inhibitor of VEGFR and FGFR (IC50s 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4 respectively) selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 UM inhibits PDGFRa PDGFRB and DDR1 (IC50s 35 169 and 6 nM respectively) as well as MAP4K4 MINK1 RET SIK2 YES1 and Tie2 (IC50s 49 41 8 23 152 and 174 nM respectively inhibits FGFR-dependent proliferation in H1581 lung SNU-16 stomach and RT4 bladder cancer cells (IC50s 104 132 and 192 nM respectively) and VEGF-induced tube formation by HUVECs (IC50 33 nM) decreases tumor volume in a RT4 mouse xenograft model at 20 and 40 mg/kg reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model at 30 mg/kg
Cayman Chemical 4-fluoro BZPhydrochlorIde 50mg
A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXRa and LXRB nuclear receptors with slightly reduced potency (EC50 7 and 4 M respectively) compared to the natural isomer (EC50 4 and 3 M respectively)
Cayman Chemical CInamyl3 4dIhydroxyaCyn 50mg
A sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1 8 sodium channels (IC50 8 nM when stimulated at half-maximal inactivation and IC50 79 nM at a resting state) dose dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models
Cayman Chemical BYK 191023hydrochlorIde 50mg
A peptidomimetic inhibitor of FTase (IC50 500 pM) selective for FTase over GGTase I (IC50 50 nM) inhibits the growth of NIH3T3 cells expressing RasF at 20 UM reduces tumor growth in a mouse xenograft model using Calu-1 cells that contain a K-Ras oncogenic mutation
Cayman Chemical MadecasIc AcId 100mg
A thoester substrate analog of 2-AG that can be utlzed for the measurement of MAGL actvty hydrolyss of the thoester bond by MAGL generates a free thol that reacts rapdly wth the chromogenc reagent DTNB resultng n a yellow product wth an absorbance maxmum at 412 nm
Cayman Chemical Agomelatn 50mg
mmunogen Recombnant human HPGDS Host Rabbt Speces Reactvty ( ) Human mouse Cross Reactvty ( ) HPGDS Applcatons HC WB MW 24 kDa
Cayman Chemical MBZPhydrochlorIde 100mg
AS-604850 is a selective ATP-competitive inhibitor of PI3KY with IC50 values of 0 25 20 20 and 4 5 UM for the human recombinant Y delta B and a isoforms respectively 13338 AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 UM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42 4 mg/kg 13338