Human Sera
Cayman Chemical CItalopramhydrobromIde 100mg
A selective serotonin reuptake inhibitor (IC50 = 1.8 nM for 5-HT reuptake in rat brain synaptosomes); selective for 5-HT reuptake over that of dopamine and norepinephrine (IC50s = >6 mM); potentiates 5-hydroxy-L-tryptophan-induced headweaving and tremor in mice (ED50s = 0.61 and 0.66 mmol/kg, respectively); acts as an antagonist of nicotinic acetylcholine receptors (IC50 = 0.93 µM)
Cayman Chemical DabrafenIbmesylate 50mg
An ATP-competitive Raf kinase inhibitor (IC50s = 0.64, 0.68, and 5 nM for wild-type B-RAF kinase, mutant B-RAFV600E, and wild-type C-RAF kinase, respectively); also inhibits ALK5, LIMK1, SIK2, PDK2, NEK11, CK1, and BRK (IC50s = 11, 15, 27, 57, 20, 41, and 79 nM, respectively) in a panel of 270 kinases at 300 nM; inhibits the growth of 16 cancer cell lines expressing mutant B-RAFV600E (GI50s = 50s = 50s = V600E-expressing A375P melanoma cells; reduces tumor growth in an A375P mouse xenograft model at 3-100 mg/kg
Cayman Chemical A2764hydrochlorIde 100mg
An inhibitor of K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor); selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM; inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons at 100 µM
Cayman Chemical BenIdIpInhydrochlorIde 50mg
An orally bioavailable inhibitor of L-, T-, and N-type calcium channels; IC50 = 2.7 nM in guinea pig ventricular cells; prevents oxidative stress in vitro and in neural stem cells; has antihypertensive effects; competitive antagonist at mineralocorticoid receptors
Cayman Chemical 10 ZPentadeceNIc ACD mth 50mg
A methyl ester form of 10(Z)-pentadecenoic acid; has been used as a standard for the quantification of pentadecenoic acid in vernix caseosa
Cayman Chemical 25T4-NBOMehydrochlorIde 50mg
A derivative of 2C-T-4, characterized by the addition of a benzyl-methoxy (BOMe) group to the amine
Cayman Chemical ErgoloIdmesylates 100mg
A mixture of alkaloids with diverse biological activities; blocks norepinephrine-induced reflex vasodilation and vasoconstriction in dogs when injected into the kidney at a dose of 0.15 mg; blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner; acts as an erectogenic agent in rats
Cayman Chemical N-AcetylserotonIn 100mg
The immediate precursor of melatonin that is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and converted to melatonin by acetylserotonin O-methyltransferase; acts as an agonist at the melatonin receptors MT1, MT2, and MT3
Cayman Chemical PalIperIdon 100mg
An atypical antipsychotic; an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively) as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively); binds to α1- and α2-adrenergic receptors, histamine H1 receptors, and the 5-HT receptor subtypes 5-HT1A , 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively); improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia at 0.05 mg/kg per day; an active metabolite of risperidone
Cayman Chemical CnabIdIvarIn 50mg
An analytical reference standard categorized as a phytocannabinoid; considered an impurity in the commercial preparations of cannabidiol; intended for research and forensic applications
Cayman Chemical Rfapentn 50mg
A long-lasting rifamycin antibiotic that is effective against Mycobacterium species, including M. tuberculosis as well as experimental infections caused by S. aureus, S. pyogenes group A, S. pneumoniae, and K. pneumoniae
Cayman Chemical FusIdIc AcIdodIum salt 100mg
A fusidane antibiotic; active against a variety of Gram-positive bacteria (MIC50s = 0.01-20 UG/ml) but not Gram-negative bacteria or fungi (MIC50s = >100 UG/ml for all); inhibits EF-G-mediated ribosomal recycling and protein translocation in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively); reduces the number of skin CFUs and levels of TNF-α and IL-6 in a mouse model of MRSA skin wound infection
Cayman Chemical FexofenadInhydrochlorIde 50mg
A histamine H1 receptor antagonist (Ki = 10 nM); reverses acetyl-β-methylcholine-induced contraction of isolated rat tracheal strips; inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells; reduces severity of colitis and phospho-IκB kinase activation in a mouse model of DSS-induced colitis