Human Sera
Cayman Chemical -SulpIrIde 50mg
An atypical antipsychotic; binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively); selective for dopamine D2 and D3 over D1 receptors and 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = >10,000 nM); increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5CSRTT in rats at 0.5 or 1 ng per animal; increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice from 12.5 to 50 μmol/kg twice per day for 3 days
Meso Scale Discovery RPLEX HUM C1q receptor ASYQP
The R-PLEX Human C1q Receptor Assay Kit from Meso Scale Discovery is used to quantitatively measure C1q receptor levels in human serum plasma cell culture supernatants and other biological samples This electrochemiluminescent immunoassay utilizes MSD s proprietary SULFO-TAG labels and multi-array plate technology to provide sensitive and reproducible results The kit includes a 96-well plate pre-coated with capture antibody detection antibody conjugated to ruthenium label calibrators and assay diluent The C1q receptor plays an important role in the clearance of apoptotic cells and immune complexes Monitoring levels of this receptor may have research and diagnostic utility
Cayman Chemical IsovalerylLcarnItInchlor 100mg
A naturally occurring acylcarnitine; formed via metabolic conversion of L-leucine; increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes at 1 mM; inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver at 77 and 100 μM, respectively
Cayman Chemical DIphenylamIn 100mg
An antioxidant and a pesticide; inhibits the oxidation of α-farnesene in solution as well as in the coating of Granny Smith apples postharvest; prevents superficial scald in several varieties of apples when applied by dipping or wrapping postharvest at 1,000 ppm; active against various benomyl-resistant or -sensitive isolates of the plant pathogenic fungus P. expansum (EC50s = <2-12.8 and 22.9-78.5 UG/ml, respectively); induces mortality in sheep keds at 0.25%; has been found as a contaminant in various jellies and jams and seawater
Cayman Chemical 1PalmItoyl2ArachIdonylsn 100mg
A phospholipid; found in biological membranes; is oxidized in vivo and has been used to study signaling of oxidized phospholipids; levels are decreased in isolated human multiple myeloma cells
Cayman Chemical 1R 3R3Hydroxycyclopentn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical -FluvalInate 50mg
A pyrethroid acaricide; induces tail currents in AmNav1 and VdNav1 channels expressed Xenopus oocytes (EC50s = 60 and 160 nM, respectively) with a faster tail current decay in VdNav1 channels; topical application at 2 µl in combination with coumaphos, atrazine, 2,4-DMPF, chlorpyriphos, and chlorothalonil does not affect honeybee queen mass, egg-laying patterns, or the mass of daughter worker bees at emergence
Cayman Chemical 4ethylN NDImethylcathInon 50mg
A potential stimulatory designer drug of the amphetamine and cathinone chemical classes; intended for forensic purposes
Cayman Chemical Lys05hydrochlorIde 50mg
An inhibitor of autophagy; induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner; increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model at 76 mg/kg; reduces tumor growth rate, volume, and weight in an HT-29 colon cancer mouse xenograft model at ≥10 mg/kg but increases bowel thickness and obstruction at 80 mg/kg
Cayman Chemical Boldenon CypIonate 50mg
An ester of boldenone, an anabolic androgenic steroid; intended for forensic and research purposes only
Cayman Chemical Dihydrocapsaicin 50MG
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 UG/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in normal WI38 lung fibroblasts and H1299, but not A549 or H460, lung cancer cells at 200 µM; a TRPV1 agonist; inhibits TPA-induced NETosis in isolated human neutrophils; induces cortical and systemic hypothermia and reduces infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 0.5 mg/kg
Cayman Chemical GemcItabInhydrochlorIde 50mg
An active metabolite of NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates; cytotoxic to HepG2 and A549 cells (IC50s = 5.2 and 16 nM, respectively); inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models; sensitizes tumors to PD-1-targeting antibodies, decreases the number of tumor-infiltrating Tregs, and increases survival in an MC-38 syngeneic mouse model of colon carcinoma at 12 mg/kg
Cayman Chemical PIperoxnhydrochlorIde 100mg
An α2-AR antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively); reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats at 10 mg/kg
Cayman Chemical TeIcoplnIn Complex 100mg
A mixture of closely related metabolites produced by A. teichomyceticus that are effective against Gram-positive bacteria; prevents bacterial cell-wall synthesis by binding and sequestering a cell-wall precursor with a D-alanine-containing peptide
Cayman Chemical FInasterIde 100mg
An inhibitor of 5α-reductase type II (IC50 = 4.2 nM); 100-fold selective for 5α-reductase type II over type I; does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and HO-1; decreases prostatic diameter and volume, as well as dihydrotestosterone serum levels in dogs with spontaneous benign prostatic hypertrophy at 0.1 and 0.5 mg/kg; reduces testosterone-induced type I procollagen and TGF-β1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia at 0.1 µM