Guinea Pig Whole Blood
Cayman Chemical HexacosnoIc ACD methyl Ste
An anticonvulsant increases glucose fructose-16-bisphosphate and pyruvate levels in rat brain at 200 mg/kg reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions at 400 mg/kg inhibits PTZ- or brainstem stimulation-induced tonic hindlimb extension (ED50s 35 and 70 mg/kg respectively) as well as leptazol-induced clonic seizures (ED50 230 mg/kg) in rats reduces resting tremor by 60 in a macaque model of Parkinsons disease induced by MPTP when administered at a dose of 150 mg/animal
Cayman Chemical DocosapentaenoIc ACD ethyl1mg
A selective short-acting adenosine A2A receptor agonist (Ki 1 1 nM for pig striatum A2A receptor) used to induce hyperemia particularly in the context of myocardial perfusion imaging
Cayman Chemical DeuTRated ArachIdonIc ACD C
An orally bioavailable SARM that binds to the androgen receptor with a Ki value of 7 nM stimulates muscle weight increase without affecting prostate or seminal vesicle in castrated male rats
Cayman Chemical DocosahexaenoIc ACD 1 2 3 4
Immunogen Peptide corresponding to amino acid residues from the C-terminus of rat ERK/MAPK Host Rabbit Species Reactivity ( ) Human Mouse Rat Applications ICC and WB MW 44 and 42 kDa for ERK1/MAPK3 and ERK2/MAPK1 respectively
Cayman Chemical GlycochenodeoxycholIc ACD Ma
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr53 of mouse NCC Host Rabbit Species Reactivity ( ) Human Mouse Rat Applications IF WB MW 160 kDa
Cayman Chemical DocosapentaenoIc ACD ethyl10mg
An active metabolite of losartan inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM a PPARY agonist (EC50 17 1 UM in COS-7 cells expressing human PPARY using a reporter assay) increases lipid accumulation in 3T3-L1 adipocytes at 10 UM decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2a levels in HUVECs at 10 UM
Cayman Chemical DocosatrIenoIc ACD methyl25mg
A second messenger that is biosynthesized from GTP by guanylate cyclases activates protein kinase G (PKG) and modulates ion channel conductance with signaling affecting diverse processes including smooth muscle relaxation and proliferation phototransduction and energy homeostasis
Cayman Chemical PalmItoleIc ACD methyl STR
A prodrug form of imidaprilat inhibits swine renal cortex ACE activity in vitro (IC50 9 9 UM) inhibits the angiotensin I-induced pressor response in normotensive rats decreases blood pressure in spontaneously hypertensive and 2K-1C renal hypertensive rats at 2 mg/kg decreases stroke incidence and increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet reduces urinary albumin excretion in a mouse model of streptozotocin-induced diabetes at 5 mg/kg
Cayman Chemical DocosapentaenoIc ACD ethyl50mg
An active metabolite of losartan inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM a PPARY agonist (EC50 17 1 UM in COS-7 cells expressing human PPARY using a reporter assay) increases lipid accumulation in 3T3-L1 adipocytes at 10 UM decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2a levels in HUVECs at 10 UM
Cayman Chemical EIcosapentaenoIc ACD Alkyn
An oxidized form of heme that inhibits eIF2aK1 a repressor of eIF-2a used experimentally to induce the expression of heme oxygenase-1 in cells and in animals
Cayman Chemical 8 Z 14 ZEIcosadIenoIc ACD
A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling particularly through disulfide linkages with cysteine residues on proteins
Cayman Chemical Polyunsaturated Faty ACD Ma
A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling particularly through disulfide linkages with cysteine residues on proteins
Cayman Chemical MaleImIdoACtIc ACD Nhydrox
A mAChR antagonist (Kis 0.42 1.77 0.52 0.78 and 1.29 nM for the M1-M5 receptors respectively) induces relaxation of precontracted isolated human bronchi at 0.01 0.1 or 1 UM reduces post-prandial gastric antral motility in dogs at 0.01 mg/kg inhibits salivation in a rat model of pilocarpine-induced sialorrhea (ED50 0.74 Ug/kg)
Cayman Chemical 4AmInobenzoIc ACD hydrazID
A prodrug form of remogliflozin A inhibits human SGLT2 and SGLT1 (Kis 1.95 and 43.1 M respectively) inhibits increases in plasma glucose levels in a glucose tolerance test in a rat model of STZ-induced diabetes at 3 and 10 mg/ml increases fasting plasma insulin levels and reduces fasting plasma glucose and triglyceride levels as well as urinary glucose excretion in a db/db mouse model of diabetes with hyperinsulinemia and obesity at 10 and 30 mg/kg twice per day for 6 weeks
Cayman Chemical ArachIdonIc ACD 1 2 3 4 513
A pan Akt inhibitor (Ki 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction