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A partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay); induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle; completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs (5 mg/kg); reverses the antitussive effect of baclofen in cats (3 mg/kg)
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An esterified version of the free acid which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements
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An ester form of DGLA; dietary administration of ethyl DGLA at 1 g/kg per day increases PGE1 and PGE2 secretion in rabbit renal papilla; increases triglyceride levels and the proportion of 20:3ω6 and 20:4ω6 phospholipids of the renal medulla in rabbits
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An ester form of DGLA; dietary administration of ethyl DGLA at 1 g/kg per day increases PGE1 and PGE2 secretion in rabbit renal papilla; increases triglyceride levels and the proportion of 20:3ω6 and 20:4ω6 phospholipids of the renal medulla in rabbits
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A mixture of fatty acid methyl esters; contains 37 saturated and mono- and poly-unsaturated fatty acid methyl esters; intended for use as a reference standard for the detection of fatty acids in various sample types by GC-MS; supplied in an amber ampule in which the headspace has been purged with nitrogen/argon to prevent lipid oxidation.
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A derivative of L-proline with diverse biological activities; induces misfolding of proteins and reduces the extracellular localization of collagen; inhibits growth of 450.1 murine mammary cancer cells in vitro (IC50 = 7.6 UG/ml) but is inactive in a 450.1 murine model of mammary cancer at 12.5-200 mg/kg per twice per day; teratogenic to, and disrupts skeletal development in, hamster fetuses when administered to pregnant hamsters at 300 mg/kg on gestational day 11
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A potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay); induces GPR35 translocation from the plasma membrane to the cytoplasm (EC50 =22 nM); increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a; has antinociceptive effects in a mouse abdominal constriction model of visceral pain perception (ED50 = 40.5 mg/kg)
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