Secondary Antibodies
Cayman Chemical MetoclopramIDhydroCLOrID 100g
An oxidized phospholipid formed in A23187-activated monocytes by direct oxidation of endogenous PE
Cayman Chemical ObIdoxImechlorIde 250mg
An NSAID inhibits ragweed- A23187- or concanavalin A-induced histamine release in isolated human leukocytes at 0 5 mM inhibits carrageenan-induced paw edema in rats (ED50 67 mg/kg)
Cayman Chemical ObIdoxImechlorIde 500mg
An NSAID inhibits ragweed- A23187- or concanavalin A-induced histamine release in isolated human leukocytes at 0 5 mM inhibits carrageenan-induced paw edema in rats (ED50 67 mg/kg)
Cayman Chemical EGFRPhosphoTyr1173RabbIt100uL
A major active metabolite of metamizole inhibits A23187-induced PGE2 production in isolated mouse peritoneal macrophages at 0.1 mM increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia at 160 Ug/paw reduces LPS-induced pyrexia in rats at 60 90 and 120 mg/kg a potential impurity found in commercial preparations of metamizole
Cayman Chemical HIstonH2AZK7AcMoncLNal100ug
A major active metabolite of metamizole inhibits A23187-induced PGE2 production in isolated mouse peritoneal macrophages at 0.1 mM increases the paw withdrawal threshold in a rat model of carrageenan-induced hyperalgesia at 160 Ug/paw reduces LPS-induced pyrexia in rats at 60 90 and 120 mg/kg a potential impurity found in commercial preparations of metamizole
Cayman Chemical N- S- 4-NItrophenoxyphenox 10g
A phthalide with diverse biological activities inhibits TPA and A23187-induced histamine release from HMC-1 cells at 10 UM induces the production of ROS ER stress and apoptosis in HCT116 cells at 100 UM prevents ethanol-induced gastric ulcers in rats at 10 mg/kg decreases aggregation of amyloid-B in brain and improves spatial and learning memory in the APP/PS1 transgenic mouse model of Alzheimers disease at 2 mg/kg
Cayman Chemical 2-DeoxycytIdInhydrochlorI 1g
A 5-LO inhibitor (IC50 23 nM in rat basophil leukemia cell lysates) inhibits A23187-induced LTB4 formation in isolated human whole blood (IC50 160 nM) inhibits LTE4 and LTB4 biosynthesis in the peritoneal cavity in a rat model of anaphylaxis (ED50s 1 4 and 0 6 mg/kg respectively) inhibits arachidonic acid-induced bronchoconstriction in anesthetized guinea pigs (ED50 3 mg/kg)
Cayman Chemical 2-DeoxycytIdInhydrochlorI 5g
A 5-LO inhibitor (IC50 23 nM in rat basophil leukemia cell lysates) inhibits A23187-induced LTB4 formation in isolated human whole blood (IC50 160 nM) inhibits LTE4 and LTB4 biosynthesis in the peritoneal cavity in a rat model of anaphylaxis (ED50s 1 4 and 0 6 mg/kg respectively) inhibits arachidonic acid-induced bronchoconstriction in anesthetized guinea pigs (ED50 3 mg/kg)
Cayman Chemical EdrophonIumchlorIde 250mg
A 5-LO inhibitor (IC50 0.8 UM) 100-fold selective for 5-LO over 12-LO and COX inhibits A23187-induced production of 5-HETE and LTB4 (IC50s 0.03 and 0.08 UM respectively) in isolated rat peritoneal macrophages reduces carrageenan-induced paw edema pleurisy and cell infiltration in rats at 80 mg/kg reduces ovalbumin-induced bronchoconstriction in an ovalbumin-sensitized guinea pig model of experimental allergic asthma at 20 mg/kg
Cayman Chemical N- S- 4-NItrophenoxyphenox 25g
A phthalide with diverse biological activities inhibits TPA and A23187-induced histamine release from HMC-1 cells at 10 UM induces the production of ROS ER stress and apoptosis in HCT116 cells at 100 UM prevents ethanol-induced gastric ulcers in rats at 10 mg/kg decreases aggregation of amyloid-B in brain and improves spatial and learning memory in the APP/PS1 transgenic mouse model of Alzheimers disease at 2 mg/kg
Cayman Chemical 5-FluorocytosIn 5g
A reversble 5-LO nhbtor nhbts 5-LO actvty n RBL-1 cell supernatant (C50 0 5 UM) nhbts LTB4 producton nduced by A23187 n purfed human PMNLs (C50 0 6 UM) prevents antgen challenge-nduced ncreases n specfc lung resstance n a sheep model of asthma at 4 to 8 hours post-challenge at 10 mg/kg p o 2 hours pre-challenge
Cayman Chemical 2 4-DIbromoacetophenon 10g
An NSAID inhibits PGE2 and LTC4 production in A23187-stimulated isolated mouse peritoneal macrophages at 100 UM inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes at 25 and 50 Ug/ml induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner at 10 UM reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice
Cayman Chemical PerfluoropentnoIc AcId 25g
An NSAID inhibits PGE2 and LTC4 production in A23187-stimulated isolated mouse peritoneal macrophages at 100 UM inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes at 25 and 50 Ug/ml induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner at 10 UM reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice
Cayman Chemical 2 4-DIbromoacetophenon 50g
An NSAID inhibits PGE2 and LTC4 production in A23187-stimulated isolated mouse peritoneal macrophages at 100 UM inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes at 25 and 50 Ug/ml induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner at 10 UM reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice
Cayman Chemical EdrophonIumchlorIde 500mg
A 5-LO inhibitor (IC50 0.8 UM) 100-fold selective for 5-LO over 12-LO and COX inhibits A23187-induced production of 5-HETE and LTB4 (IC50s 0.03 and 0.08 UM respectively) in isolated rat peritoneal macrophages reduces carrageenan-induced paw edema pleurisy and cell infiltration in rats at 80 mg/kg reduces ovalbumin-induced bronchoconstriction in an ovalbumin-sensitized guinea pig model of experimental allergic asthma at 20 mg/kg
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