Goat Secondary Antibodies
Cayman Chemical Diphenylpyraline, Purity: ≥95%, CAS: 147-20-6, 250 mg
A histamine H1 receptor antagonist (Ki = 20 nM); inhibits ovalbumin-induced bronchoconstriction in ovalbumin-sensitized guinea pigs at 20 µmol/kg; reduces dopamine uptake in rat nucleus accumbens at 14 mg/kg
Cayman Chemical Maltose (hydrate), Purity: ≥90%, CAS: 6363-53-7, 250 g
A disaccharide; a degradation product of starch; a source of glucose in bacteria and mammals
Cayman Chemical Sophoradin, Purity: ≥95%, CAS: 6882-68-4, 250 mg
A quinolizidine alkaloid; reduces viral titers in CVB3-infected primary neonatal rat cardiomyocytes at 1 and 5 µg/ml; inhibits the growth of, and induces apoptosis in, SW480 colorectal cancer cells, as well as reduces tumor growth in an SW480 mouse xenograft model; reduces increases in TNF-α, IL-8, and PGE2 levels in a mouse model of carrageenan-induced paw edema at 12.15 and 48.6 mg/kg
Cayman Chemical 2-Hydroxyanthraquinone, Purity: ≥98%, CAS: 605-32-3, 10 g
An anthraquinone with antibacterial and estrogenic activities; active against B. subtilis and B. cereus (MICs = 1.9 and 62.5 µg/ml, respectively); induces ERα activation in a yeast two-hybrid assay at 19 µM
Cayman Chemical Isoalantolactone, Purity: ≥98%, CAS: 470-17-7, 250 mg
A sesquiterpene lactone with diverse biological activities; inhibits proliferation of PANC-1, BxPC-3, and HPAC pancreatic cancer cells (IC50s = 40, 43, and 48 µM, respectively); induces apoptosis, cell cycle arrest at the S phase, and the production of ROS in PANC-1 cells; decreases LPS-induced production of NO, PGE2, IL-6, and TNF-α in RAW 264.7 macrophages at 4 and 8 µM; reduces production of S. aureus α-toxin in a concentration-dependent manner and increases survival in a mouse model of S. aureus-induced pneumonia at 50 mg/kg
Cayman Chemical Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt), Purity: ≥98%, 5 mg
A synthetic peptide fragment of galanin and an agonist of the GAL2 receptor (EC50 = 9.32 nM in a fluorescence imaging plate reader assay); selectively binds to the GAL2 receptor (IC50 = 1.76 nM for the rat receptor) over the GAL1 receptor (IC50 = 879 nM for the human receptor) but does also bind to the GAL3 receptor (Ki = 271 nM for the rat receptor); decreases immobility in the forced swim test in rats at 1 nmol/animal, i.c.v.; reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats
Cayman Chemical L-Asparagine (hydrate), Purity: ≥95%, CAS: 5794-13-8, 1 g
A non-essential amino acid; reverses ASNS siRNA knockdown-induced decreases in proliferation in a panel of six cancer cell lines at 0.3 mM
Cayman Chemical Dehydroabietic Acid, Purity: ≥90%, CAS: 1740-19-8, 250 mg
A diterpene acid with diverse biological activities; active against L. amazonensis promastigotes (IC50 = 40 µg/ml); increases the number of mitochondrial ridges, decreases mitochondrial outer membrane rupture, and increases the expression of FSP1 and COQ10 in an HL7720 cell model of oleic acid-induced ferroptosis at 2.5, 5, and 10 µM; reduces hepatic total cholesterol and triglyceride levels, ferroptosis, and lipid peroxidation in a mouse model of high-fat diet-induced NAFLD at 10 and 20 mg/kg; found in wood industry effluents and is considered a pollutant; increases oxygen consumption and cellular heat production and reduces cellular ATP content in isolated rainbow trout hepatocytes
Cayman Chemical CelularMetabolIsmScreeng50uL
A GABAB receptor agonist increases latency to paw or tail withdrawal in the hot-plate test in mice at 1 and 3 mg/kg reduces the number of lever responses for alcohol in Sardinian alcohol-preferring rats at 3 mg/kg
Cayman Chemical 7-Methoxyflavone, Purity: ≥98%, CAS: 22395-22-8, 10 g
A flavone; inhibits aromatase in a cell-free assay (IC50 = 1.9 µM); inhibits LPS-induced NO production by 17.74% in RAW 264.7 macrophages at 20 µM; activates androgen and/or glucocorticoid receptor transcriptional activity in a reporter assay; has antinociceptive activity in the acetic acid-induced writhing test in mice (ED50 = 82.5 µmol/kg)
Cayman Chemical D-Galacturonic Acid (hydrate), Purity: ≥95%, CAS: 91510-62-2, 10 g
A monosaccharide; a major component of pectin; increases body weight and reduces intestinal mucosal permeability in a rat model of iodoacetamide-induced functional dyspepsia at 200, 400, and 800 mg/kg
Cayman Chemical Saralasin (trifluoroacetate salt), Purity: ≥98%, 50 mg
A peptide AT2 receptor agonist; binds to AT2 receptors (Ki = 0.38 nM); induces neurite outgrowth in NG108-15 cells at 100 nM; enhances acquisition of the conditioned avoidance response in rats at 5 µg/animal
Cayman Chemical Acetylthiocholine (iodide), Purity: ≥95%, CAS: 1866-15-5, 5 g
A substrate for AChE and an agonist of α4β2 subunit-containing nAChRs; binds to α4β2 subunit-containing nAChRs in SH-EP1 cells (IC50 = 7.1 µM); induces rubidium efflux in an agonist-induced rubidium efflux assay (EC50 = 100 µM); has been used as part of a thiocholine sensor for the detection of pesticides in complex sample types
Cayman Chemical 7-Methoxy-4-(trifluoromethyl)coumarin, Purity: ≥95%, CAS: 575-04-2, 100 mg
A fluorogenic substrate for CYPs; HFC is released upon enzymatic cleavage by CYPs and its fluorescence can be used to quantify CYP activity; ex/em = 410/510 nm, respectively
Cayman Chemical 5,6-Dihydrouridine, Purity: ≥95%, CAS: 5627-05-4, 250 mg
A pyrimidine nucleoside and derivative of uridine; present in tRNA from bacteria, eukaryotes, and some archaea; inhibits E. coli cytidine deaminase in a cell-free assay (Ki = 3.4 µM); serum levels are increased in patients with prostate cancer and positively correlated with lethality