Goat Secondary Antibodies
Cayman Chemical Pyrantel (pamoate), Purity: ≥95%, CAS: 22204-24-6, 50 g
An anthelmintic and agonist of nAChRs; activates chimeric C. elegans α7-nAChR expressed in BOSC cells (EC50 = 40 μM); induces contraction of A. suum muscle (EC50 = 57.5 nM); decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 μg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 μg/ml, respectively) in vitro; decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice at 6 mg/kg
Cayman Chemical Nitroxoline, Purity: ≥95%, CAS: 4008-48-4, 10 g
An 8-hydroxyquinoline; active against the bacteria E. coli, S. aureus, E. faecalis, K. pneumoniae, and P. mirabilis in vitro (MIC90s = 4, 4, 8, 8, and 8 mg/L, respectively); inhibits biofilm formation of certain strains of MDR A. baumannii and P. aeruginosa, as well as MRSA and MRSE (MBECs = 46.9, 1,500, 188, and 125 μM, respectively); inhibits the growth of human U87 and U251 glioma, A549 lung, and PC3 prostate cancer cells (IC50s = 50, 6, 38, and 23 μg/ml, respectively); reduces tumor growth in a PTEN- and KRAS-driven glioma mouse model at 80 mg/kg per day; inhibits the interaction between the first bromodomain of BRD4 with acetylated histone H4 (IC50 = 0.98 μM)
Cayman Chemical Pioglitazone (hydrochloride), Purity: ≥98%, CAS: 112529-15-4, 500 mg
A PPARγ agonist (EC50 = ~ 500-600 nM for both human and murine PPARγ); selective for PPARγ over PPARα exhibiting low level activation of PPARα at 1 µM and 5.4-fold activation at a concentration of 10 µM; reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats from 0.3-3 mg/kg; reduces the number of lesions in a TRAP model; decreases production of neuroinflammatory cytokines and reduces immobility in the forced swim and tail suspension tests in a mouse model of chronic mild stress at 2.5 mg/kg
CPC Scientific H-DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg-OH (trifluoroacetate salt) 0.5MG
ONE-LETTER SEQUENCE: rRP-Hyp-G-Igl-S-DIgl-Oic-R MOLECULAR FORMULA: C64H94N19O13MOLECULAR WEIGHT:1338.58STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [180981-09-3], SYNONYMS: B-9430, (D-Arg,Hyp,Igl,D-Igl,Oic)-BradykininRESEARCH AREA: Cardiovascular
Cayman Chemical Ethacridine (lactate), Purity: ≥98%, CAS: 1837-57-6, 5 g
An inducer of uterine contraction; induces contractions in primary mouse myometrium smooth muscle cells when co-cultured with primary degranulated mast cell and isolated and washed mouse uterine horns at 10 µM; preincubation of viral particles reduces SARS-CoV-2 viral titers in a plaque assay, as well as decreases the levels of intracellular and extracellular viral RNA and the intracellular levels of the N protein and S protein, in Vero E6 cells at 5 µM; decreases colony formation by, and induces apoptosis in, SW1736 and FTC-133 cancer cells at 10 µM; reduces the levels of mRNA encoding TTF-1, Pax8, and NIS in Nthy-ori 3-1 thyroid follicular epithelial cells at 10 µM
Cayman Chemical THUNDERPhosphoCREBS133 2400
Sandwich TR-FRET immunoassay for semi-quantitative detection of Phospho-CREB (S133) in cell lysates
Cayman Chemical Nitrotyrosine, Purity: ≥98%, CAS: 621-44-3, 25 g
Nitrotyrosine is formed by peroxynitrite-mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation in vivo.{5439,1269,4663,5357} Both free and protein-bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions.{1269,7112,11380} The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by GC/MS.{10970,7925}
Cayman Chemical L-Lysine lactam (hydrochloride), Purity: ≥95%, CAS: 26081-07-2, 1 g
A building block; has been used in the synthesis of HIV protease inhibitors, as well as bengamide derivatives with in vitro anticancer activity
Cayman Chemical Toltrazuril sulfone, Purity: ≥98%, CAS: 69004-04-2, 250 mg
An active metabolite of toltrazuril; formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by CYP enzymes, including CYP3A; inhibits T. gondii tachyzoite production in African green monkey kidney cells at 0.1, 1, and 5 µg/ml; completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis at 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection; reduces the number of infected mice in the same model at 10 mg/kg for 11 days starting six days following infection
Cayman Chemical Sphingosine-1-phosphate (d17:1), Purity: ≥95%, CAS: 474923-27-8, 5 mg
A synthetic sphingolipid; has been used as an internal standard for the quantification of S1P (d18:1) in plasma and tissue samples
Cayman Chemical (R)-(+)-Pulegone, Purity: ≥95%, CAS: 89-82-7, 10 g
A monoterpene with anti-inflammatory activity; stimulates proliferation of lymphocytes derived from allergic patients in vitro at 6.2 and 62 µg/ml; decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at 0.1-10 µM; decreases serum IgE levels and skin protein levels of inflammatory cytokines including IFN-γ, IL-6, IL-1β, TNF-α, and NF-κB in skin
CPC Scientific H-DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DIgl-Oic-Arg-OH (trifluoroacetate salt) 0.5MG
ONE-LETTER SEQUENCE: rRP-Hyp-G-Thi-S-DIgl-Oic-R MOLECULAR FORMULA: C60H90N19O13S1MOLECULAR WEIGHT:1317.6STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [175413-73-7], RESEARCH AREA: Cardiovascular
Cayman Chemical 6-Nitroveratraldehyde, Purity: ≥98%, CAS: 20357-25-9, 50 g
A photolabile H+-donor used in fluorescence imaging; releases acid when excited at 405 nm; has been used for fluorescence imaging, in conjunction with pH sensitive fluorescent probe cSNARF1, to study nuclear proton dynamics, acid venting from cancer cells, and hemoglobin-restricted diffusion in the cytoplasm of red blood cells; has been used as a precursor for [18F]fluoride displacement reactions in the synthesis of NCA 6-[18F]fluoro-L-dopa
Cayman Chemical Precelys MInIlys Tubes Bl 1ea
Package includes everything needed to replace the tubes blocking rod on the Minilys instrument (Item No. 10435). This product is recommended to be replaced once per year or when necessary. [Bertin Catalog S000682-MLYS0-A.0; Previously SP06404-810-NC001.0]
Cayman Chemical trans-10-hydroxy Nortriptylin
An active metabolite of amitriptyline and nortriptyline; formed from amitriptyline and nortriptyline by CYP2D6; inhibits norepinephrine reuptake in rat cortical slices and isolated human plasma (EC50s = 160 and 176 nM, respectively)