Custom Enzymes and Inhibitors
Medchemexpress LLC LM11A-31 dihydrochloride | 1243259-19-9 | 99.9% | 316.27 | 10 MG
LM11A-31 dihydrochloride is a non-peptide p75NTR (neurotrophin receptor p75) modulator and an orally active, potent proNGF (nerve growth factor) antagonist. It is an amino acid derivative with high blood-brain barrier permeability that blocks p75-mediated cell death. This compound reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models at mid- to late-stage disease progression. It is for research use only.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative
- High blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
- Mitigates proNGF accumulation and preserves BRB integrity (in vivo)
- Prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice (in vivo)
Medchemexpress LLC NAE-IN-M22 10mg | 864420-54-2 | 363.32 g·mol-1 | C20H24Cl2N2 | 10 MG
NAE-IN-M22 is a potent, selective, and reversible inhibitor of the NEDD8-activating enzyme (NAE) used as a research tool to study neddylation-dependent signaling and apoptosis in cancer cell models. Supplied as a high-purity small-molecule solid, it is intended for laboratory research use only.
- Inhibits NEDD8-activating enzyme in vitro and in vivo.
- High purity (99.94%).
- Supplied in mg-scale pack sizes, including 10 mg.
- Suitable for studies of neddylation, ubiquitin-like modification, and apoptosis.
- Store powder at -20°C for long-term stability; follow solvent storage recommendations for solutions.
eMolecules 940929-33-9 | SB-743921 | MFCD18385010 | 50mg
Ambeed | SB-743921 | 50mg | 552749714 | A654863 | 940929-33-9 | MFCD18385010 | 553.520 | C31H34Cl2N2O3
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Medchemexpress LLC Pristimerin | 1258-84-0 | 464.64 | 5 MG
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM. It is also known as Celastrol methyl ester. This compound is used for research purposes.
- Potent and reversible monoacylglycerol lipase (MGL) inhibitor.
- Inhibits angiogenesis by suppressing VEGFR2 signaling pathways.
- Exhibits anti-inflammatory properties.
- Demonstrates anti-tumorigenic properties and cytotoxicity against various human cancer cell lines.
- Attenuates activation of the VEGF-induced VEGFR2-mediated signaling pathway.
- Reduces vessel density in synovial membrane tissues.
- Decreases expression of pro-angiogenic factors like TNF-α, Ang-1, and MMP-9 in sera.
Selleck Chemical LLC Olaparib (AZD2281) 100mg 763113-22-0 Ku-0059436
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Bosutinib (SKI-606) 50mg 380843-75-4
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam Pitstop 2, Novel cell-permeable clathrin inhibitor, 5MG
MW 473.4 Da, Purity >98%. Novel, selective, cell membrane permeable clathrin inhibitor. Competitively inhibits clathrin terminal domain to selectively inhibit clathrin mediated endocytosis (CME) (IC50 = 12 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis (RME), entry of HIV and synaptic vesicle recycling.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC HY-110155A 5mg Medchemexpress, (Rac)-LM11A-31 (dihydrochloride) CAS:1214672-15-7 Purity:>98%
Medchemexpress, HY-110155A 5mg (Rac)-LM11A-31 (diHCl) CAS:1214672-15-7 (Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Athens Research And Technology Inc 100UG ANTITHROMBIN III HU
Antithrombin III, Human Plasma: 100 UG; Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl; MW 58,000; EC=0.7; Purity: > =95% by SDS-PAGE; This native protein purified in the Athens Research & Tech lab.
Selleck Chemical LLC GDC-0879 5mg 905281-76-7 AR-00341677
GDC-0879 (AR-00341677) is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM in A375 and Colo205 cells with activity against c-Raf as well; no inhibition known to other protein kinases. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Pfaltz & Bauer Hyaluronidase lyophilized powder bovine minimum 300 units/mg, 100mg
Hyaluronidase lyophilized powder bovine minimum 300 units/mg, 37326-33-3, MFCD00131351. 55 kDa, 100mg
