Custom Peptides
Cayman Chemical INCB 057643 10mg
A BET family protein inhibitor; inhibits binding of BRD2, BRD3, and BRD4 to an acetylated histone H4 peptide in vitro; decreases Myc levels in, and inhibits proliferation of, AML, DLBCL, and MM cells; reduces tumor growth in AML, DLBCL, and MM mouse xenograft models; reduces tumor growth when administered alone or in combination with docetaxel or MDV 3100 in a 22Rv1 CRPC mouse xenograft model
Cayman Chemical 6 7 4-TrIhydroxyIsoflavon 10mg
An active metabolite of daidzein; suppresses anchorage-dependent and -independent growth of HCT116 and DLD-1 colon cancer cells, as well as induces cell cycle arrest at the S and G2/M phases in HCT116 cells from 12.5-100 µM; inhibits MDI-induced adipogenesis in 3T3-L1 preadipocytes at 40 and 80 µM; reverses scopolamine-induced memory impairments and increases hippocampal BDNF and CREB levels in mice at 5 mg/kg; prevents LPS-induced bone loss in mice
Cayman Chemical JWH 122 6mthylnaphthyl 10mg
Differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 6, rather than the 4, position
Cayman Chemical 2 NEthylperfluoroctnsulf 10mg
A perfluoroalkyl substance; has been found in wastewater samples; associated with decreased plasma levels of maternal and fetal free T4
Cayman Chemical 1 2DIheptadecnoylsnglycer 10mg
A glycerophospholipid; has been used as an internal standard for the detection of phosphatidylethanolamines in human adipose tissue
Cayman Chemical TauroWmurIcholIc AcIdodI 10mg
A taurine-conjugated form of ω-muricholic acid; hepatic levels are decreased in mice following a diet supplemented with cholic, deoxycholic, chenodeoxycholic, or ursodeoxycholic acid; hepatic levels are decreased in a high-fat diet-induced mouse model of NAFLD; the predominant rare bile acid found in the serum of infants with EArly-onset neonatal sepsis
Cayman Chemical Nethyl Perfluoroctnsulfon 10mg
N-ethyl Perfluorooctanesulfonamide (N-ethyl FOSA) is a perfluoroalkyl substance (PFAS) and an insecticide.{49815,49816} It decreases the coupling efficiency, increases the rate of state four respiration, and uncouples mitochondrial oxidative phosphorylation in rat liver mitochondria when used at a concentration of 6.25 µM.{49817} N-ethyl FOSA reduces foraging activity of leaf-cutting ants (A. lundi) and reduces colony survival when applied in colonies as a 0.3% bait.{49816} It has been found in human blood and Arctic air samples.{49815,49818}
Cayman Chemical Methylcardol trIen 10mg
A phenol from cashew nut shell liquid; inhibits α-glucosidase (IC50 = 39.6 µM); kills 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 µM; has been used as a starting material for the synthesis of mono- and bis-benzoxazines
Cayman Chemical Eltrombopag 10mg
A thrombopoietin receptor agonist (EC50 = 0.27 µM) and iron chelator; It increases STAT5 phosphorylation in N2C-Tpo cells at 30 µM and p42/44 MAPK phosphorylation at 10 µM; stimulates megakaryocytopoiesis in human primary bone marrow cells; increases platelet production in chimpanzees at 10 mg/kg per day for five days; binds to iron (III) and mobilizes cellular iron and ferritin in H9C2, Huh7, and RINm5F cells
Cayman Chemical CardIogenol ChydrochLRIde 10mg
Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM
Cayman Chemical ncalctol 10mg
A vitamin D receptor agonist; induces reporter gene expression in VDR-expressing COS-1 cells at 1 nM; induces differentiation of HL-60 and MG-63 cells (EC50s = 6.2 and 0.18 nM, respectively); reduces the proliferation of MCF-7 cells (EC50 = 4.1 nM); protects primary human keratinocytes against DNA damage induced by UVB irradiation; inhibits acetylcholine- or ATP-induced contractions of aortic rings isolated from spontaneously hypertensive rats at 100 nM; unlike calcitriol, it does not increase serum calcium levels or decrease tibia calcium levels in mice at 80 UG/kg
Cayman Chemical VPMp15trIfluoroACTAte sal 10mg
A peptide ADGRG2 agonist; induces cAMP accumulation in HEK293 cells expressing human ADGRG2 (EC50 = 1.41 µM)
